Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia

Effect of Dragon Scales Leaf Ethanol Extract (Pyrrosia Piloselloides L.) on Reducing Total Cholesterol Levels in Hypercholesterolemic Mice

Authors

  • Helmice Afriyeni Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author
  • Nesya Indah Putri Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author
  • Rosiana Rizal Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i4.528%20-%20534

Keywords:

Hiperkolesterolemia, Pyrrosia piloselloides L, MDLT, Kadar Kolesterol Total

Abstract

Hiperkolesterolemia merupakan faktor risiko terjadinya penyakit kardiovaskular seperti strok, aterosklerosis dan jantung koroner. Tujuan dari penelitian ini untuk mengetahui pengaruh ekstrak etanol daun sisik naga (Pyrrosia piloselloides L.). Sebanyak 25 ekor mencit putih jantan diinduksi hiperkolesterolemia dengan makanan diet lemak tinggi (MDLT) ±14 hari, mencit dinyatakan hiperkolesterolemia jika kadar kolesterol total (KT) >230mg/dl, kemudian dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif, pembanding (simvastatin), dan kelompok yang diberi ekstrak uji dosis 25, 50, 100 mg/kgBB. Perlakuan diberikan selama 15 hari, pada hari ke 0, 5, 10 dan 15 dilakukan pemeriksaan kadar KT. Data dianalisis dengan Two Way ANOVA dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan dosis ekstrak uji dan waktu berpengaruh signifikan (p<0,05) terhadap penurunan kadar KT mencit. Semua kelompok dosis ekstrak etanol daun sisik naga memberikan efek penurunan KT pada mencit dan nilai persentase penurunannya sebanding dengan kelompok yang diberi simvastatin. Hasil ini menunjukkan ekstrak etanol daun sisik naga berpotensi dalam menurunkan kadar kolesterol total mencit hiperkolesterolemia

References

Luo, J., Jiang, L. Y., Yang, H. Y. dan Song, B. L. 2019. Intracellular cholesterol transport by sterol transfer proteins at membrane contact sites. Trends Biochem. Sci.44, 273–292.

Priya.T, Shashank,M.,and Kishwar Hayat Khan. 2013. Cholesterol: Genetic, Clinical and Natural Implications. Journal of Pharmaceutical, Biological and Chemical Sciences. ISSN: 0975-8585.

Abdel, H. A., Rakeel, H. A., Rada, H. A. 2018. Hypercholesterolemia as a risk factor for coronary heart disease. J. Of University Of Anbar For Pure Science : Vol.12 : No.3. ISSN: 1991-8941.

Beltowski, J. 2014. Reverse epidemiology in ischemic stroke: highcholesterol as a predictor of improved survival in stroke patients, Clinical Lipidology, 9:2, 135-139.

World Helth Organization (WHO). 2017. Cardiovascular diseases (CVDs). Diunduh dari: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

Atshaves ,B. P., G. G. Martin, H. A. Hostetler, A. L. McIntosh, A. B. Kier, and F. Schroeder. 2010. Liver fatty acid-binding protein and obesity. Journal of Nutritional Biochemistry. vol. 21, no. 11, pp. 1015–1032.

Libby P. 2015. The Pathogenesis, Prevention, and Treatment of Atherosclerosis. New York: McGraw-Hill Education; 291e1–291e10.

Onuah,C.L., Anacletus, F.C., Uwakwe, A.A., Okoroh,P.N. 2018. The Synergistic Effect Of Ethanol Leaf Extract Of Annona Muricata And Artocarpus Heterophyllus On High Fat Diet Induced Hyperlipidaemia In Wistar Albino Rats. World journal of pharmaceutical research. Vol 7, no 19, 52-60.

Malinda, A. F dkk. 2013. Pengaruh Pemberian Ekstrak Etanol Daun Paku Sisik Naga (Drymoglossum Piloselloides L.Presl) Terhadap Peroksidasi Lipid Hati Pada Tikus Jantan Galur Wistar Yang Diinduksi CCl4. Jurnal Ilmiah Farmasi. Vol. 2 No. 02.

Arifin H., dkk. 2017. Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides (L.) M. G Price) terhadap Waktu Pendarahan, Waktu Pembekuan Darah dan Jumlah Trombosit Mencit Putih Jantan. Jurnal Farmasi Higea, Vol. 9, No. 1.

Somchit M. N., Hassan H., Zuraini A., Chong L. C., Mohamed Z., Zakaria Z. A. 2011. In vitro anti-fungal and anti-bacterial activity of Drymoglossum piloselloides L. Presl. against several fungi responsible for Athlete's foot and common pathogenic bacteria. Afr J Microbiol Res .5(21):3537-3541.

Arief, M. Z .2018. Phytochemical Screening and Toxicological Evaluation of Pyrrosia piloselloides Extracts. International Medical Journal .Vol. 25, No. 3, pp. 177 – 180.

Lee K. H., Park E., Lee H. J., et al. 2011. Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract; 5(1):28-33.

Zeka K, et al. 2017. Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes. Journal Diseases, 5, 19; doi:10.3390.

Harborne, J.B. 1987. Metode Fitokimia. Penuntun Cara Modern Menganalisis Tumbuhan. terbitan kedua. ITB. Bandung, Indonesia.

Armenia, Ermilda, F., Widya R.M., Rusdji D.J., Netty M. 2006. Anti-Atheroschelrotic Effect and Liver Toxicity of Ethanolic Extract of Phaleria Macrocarpa (Scheff) Boerl Fruit on Japanese Quail. Oral paper ASOMP XII, 13-18.

Zhou H, Hylemon PB. 2014. Bile acids are nutrient signaling hormones. Steroids; 86: 62-8.

Santana Farre,R. et al. 2012. Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood. PLOS ONE 7, e37386.

Montoya C, Cochard B, Flori A, Cros D, Lopes R, et al. (2014) Genetic Architecture of Palm Oil Fatty Acid Composition in Cultivated Oil Palm (Elaeis guineensis Jacq.) Compared to Its Wild Relative E. Oleifera (H.B.K) Corte ´s. PLoS ONE 9(5): e95412. doi: 10.1371/journal.pone.0095412.

Patty W. Siri Tarino, Q. S. 2010. Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients. Current Atheroscler Reports, 12:384–390.

Huy L A P, Hua, H., Chuong P H. 2008. Free Radicals, Antioxidants in Disease and Health. International journal of Biomedical science. vol. 4 no. 2.

Raphael J. Ogbe et al. 2015. A review on dietary phytosterols:Their occurrence, metabolism and health benefits. Asian Journal of Plant Science and Research, 2015, 5(4):10-21.

Amany M.M. Ali*, Tawfik M.F., Hikal M.S. And Tag El-Din M.A. 2019. Hypocholesterolemic Effect Of Saponin Extracts In Experimental Animals. Arab Univ. Journal. Agric. Sci. (Aujas). 2463-2478.

Aronson, Jeffrey K,. 2007. Concentration-effect and dose-response relations in clinical pharmacology. British Journal of Clinical Pharmacology. DOI:10.1111/j.1365-2125.2007.02871.

Joudi,A, F,S. 2013. Adverse Effects of Excessive Antioxidant Supplements and Their Underlying Mechanisms. Journal Of Aging Research & Clinical Practice. Vol 2(4).

Vakil, V, Wade Trappe. Drug Combinations: Mathematical Modeling and Networking Methods. Journal Pharmaceutical. 11, 208; doi:10.3390.

Downloads

Published

2025-01-14

Issue

Vol. 5 No. 4 (2023): J. Sains Kes.

Section

Articles

License

Copyright (c) 2023 Jurnal Sains dan Kesehatan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
H. Afriyeni, N. I. Putri, and R. Rizal, “Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia: Effect of Dragon Scales Leaf Ethanol Extract (Pyrrosia Piloselloides L.) on Reducing Total Cholesterol Levels in Hypercholesterolemic Mice”, J. Sains. Kes, vol. 5, no. 4, pp. 528–534, Jan. 2025, doi: 10.30872/jsk.v5i4.528 - 534.

Similar Articles

11-20 of 134

You may also start an advanced similarity search for this article.