Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia

Effect of Dragon Scales Leaf Ethanol Extract (Pyrrosia Piloselloides L.) on Reducing Total Cholesterol Levels in Hypercholesterolemic Mice

Authors

  • Helmice Afriyeni Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author
  • Nesya Indah Putri Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author
  • Rosiana Rizal Program Studi Farmasi Universitas Dharma Andalas, Padang, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i4.528%20-%20534

Keywords:

Hiperkolesterolemia, Pyrrosia piloselloides L, MDLT, Kadar Kolesterol Total

Abstract

Hiperkolesterolemia merupakan faktor risiko terjadinya penyakit kardiovaskular seperti strok, aterosklerosis dan jantung koroner. Tujuan dari penelitian ini untuk mengetahui pengaruh ekstrak etanol daun sisik naga (Pyrrosia piloselloides L.). Sebanyak 25 ekor mencit putih jantan diinduksi hiperkolesterolemia dengan makanan diet lemak tinggi (MDLT) ±14 hari, mencit dinyatakan hiperkolesterolemia jika kadar kolesterol total (KT) >230mg/dl, kemudian dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif, pembanding (simvastatin), dan kelompok yang diberi ekstrak uji dosis 25, 50, 100 mg/kgBB. Perlakuan diberikan selama 15 hari, pada hari ke 0, 5, 10 dan 15 dilakukan pemeriksaan kadar KT. Data dianalisis dengan Two Way ANOVA dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan dosis ekstrak uji dan waktu berpengaruh signifikan (p<0,05) terhadap penurunan kadar KT mencit. Semua kelompok dosis ekstrak etanol daun sisik naga memberikan efek penurunan KT pada mencit dan nilai persentase penurunannya sebanding dengan kelompok yang diberi simvastatin. Hasil ini menunjukkan ekstrak etanol daun sisik naga berpotensi dalam menurunkan kadar kolesterol total mencit hiperkolesterolemia

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Published

2025-01-14

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Vol. 5 No. 4 (2023): J. Sains Kes.

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Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia: Effect of Dragon Scales Leaf Ethanol Extract (Pyrrosia Piloselloides L.) on Reducing Total Cholesterol Levels in Hypercholesterolemic Mice. (2025). Jurnal Sains Dan Kesehatan, 5(4), 528-534. https://doi.org/10.30872/jsk.v5i4.528 - 534