Association of Neutrophil-to-Lymphocyte Ratio and Monocyte-to-Lymphocyte Ratio with Troponin I Levels in Patients with Acute Myocardial Infarction at Advent Hospital Bandar Lampung

Revi Amanda; Hidayat; Neno Fitriyani Hasbie; Muhammad Nur

doi:10.30872/

Penulis

Revi Amanda Universitas Malahayati Penulis
Hidayat Universitas Malahayati Penulis
Neno Fitriyani Hasbie Universitas Malahayati Penulis
Muhammad Nur Universitas Malahayati Penulis

DOI:

https://doi.org/10.30872/

Kata Kunci:

Infark Miokard Akut, NLR, MLR, Troponin I, inflamasi

Abstrak

Infark miokard akut (IMA) merupakan manifestasi sindrom koroner akut yang memiliki angka morbiditas dan mortalitas tinggi. Inflamasi berperan penting dalam patogenesis IMA, sehingga biomarker inflamasi berpotensi digunakan untuk menilai derajat kerusakan miokard. Penelitian ini bertujuan menganalisis hubungan Neutrophil-to-Lymphocyte Ratio (NLR) dan Monocyte-to-Lymphocyte Ratio (MLR) dengan kadar Troponin I pada pasien IMA di RS Advent Bandar Lampung. Penelitian observasional analitik dengan pendekatan retrospektif dilakukan terhadap data rekam medis 104 pasien IMA periode Januari 2024–Desember 2025. Analisis hubungan dilakukan menggunakan uji korelasi Spearman. Sebagian besar pasien berjenis kelamin laki-laki (70,2%) dan berusia ≥65 tahun (51,0%). Nilai NLR meningkat pada 73 pasien (70,2%) dan MLR meningkat pada 55 pasien (52,9%). Nilai NLR, MLR, dan kadar Troponin I pada kelompok STEMI lebih tinggi dibandingkan NSTEMI (p<0,05). Terdapat hubungan positif yang signifikan antara NLR dan kadar Troponin I (r=0,849; p<0,001) serta antara MLR dan kadar Troponin I (r=0,705; p<0,001). NLR menunjukkan kekuatan korelasi yang lebih tinggi dibandingkan MLR. NLR dan MLR berpotensi digunakan sebagai biomarker inflamasi tambahan yang sederhana, cepat, dan ekonomis dalam evaluasi pasien IMA.

Biografi Penulis

Revi Amanda, Universitas Malahayati

Department of Medicine, Faculty of Medicine, University of Malahayati, Bandar Lampung, Indonesia
Hidayat, Universitas Malahayati

Department of Clinical Pathology, Faculty of Medicine, University of Malahayati, Bandar Lampung, Indonesia
Neno Fitriyani Hasbie, Universitas Malahayati

Public Health Program, Faculty of Medicine, University of Malahayati, Bandar Lampung, Indonesia
Muhammad Nur, Universitas Malahayati

Department of Clinical Pathology, Faculty of Medicine, University of Malahayati, Bandar Lampung, Indonesia

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