Analisis Faktor yang Berhubungan dengan Potensi Interaksi Obat Pasien Covid-19 di Salah Satu Rumah Sakit Kalimantan Selatan

Factors Associated with Potential Drug Interactions in Covid-19 Hospitalized Patients

Authors

  • Okta Muthia Sari Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author
  • Aditya Maulana Perdana Putra Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author
  • Yusrinie Wasiaturrahmah Program Studi Kedokteran Gigi, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat, Indonesia Author
  • Nahdiya Rahmah Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i5.441

Keywords:

COVID-19, faktor berhubungan, interaksi obat, potensi

Abstract

Tatalaksana pengobatan pada pasien COVID-19 diberikan antivirus, terapi suportif dan terapi simptomatik. Penggunaan beberapa jenis obat tersebut membuat pasien COVID-19 berpotensi mengalami interaksi obat. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit. Penelitian obeservasional retrospektif cross sectional ini dilaksanakan di salah satu rumah sakit Kalimantan Selatan. Sampel yakni rekam medis pasien COVID-19 yang mendapat terapi dan rawat inap di rumah sakit periode Januari-Maret 2021 Instrumen penelitian mengkaji potensi dan mekanisme interaksi obat meliputi situs IBM Micromedex , DrugBank Interaction Checker dan Stockley Drug Interactions 9th Edition. Hasil diperoleh sebanyak 82 rekam medis dianalisis potensi interaksi obat. Persentase pasien mengalami potensi interaksi obat sebesar 69,5%. pada pasien COVID-19 rawat inap di rumah sakit. Mekanisme interaksi obat pada pada pasien COVID-19 pada berpotensi pada fase farmakokinetika. Faktor berhubungan potensi interaksi obat pasien COVID-19 yakni usia (p=0.034; OR 0.327, CI 0.11-0.94), jumlah obat yang digunakan selama dirawat (p=0.002; OR 14.00, CI 1.76-111.11) dan lama dirawat (p=0.000; OR 0.009 , CI 0.001-0.07). Kesimpulan, faktor berhubungan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit meliputi usia, jumlah obat yang digunakan selama dirawat dan lama dirawat.

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Published

2024-11-15

Issue

Vol. 5 No. 5 (2023): J. Sains Kes.

Section

Articles

How to Cite

[1]
O. M. . Sari, A. M. P. . Putra, Y. . Wasiaturrahmah, and N. . Rahmah, “Analisis Faktor yang Berhubungan dengan Potensi Interaksi Obat Pasien Covid-19 di Salah Satu Rumah Sakit Kalimantan Selatan: Factors Associated with Potential Drug Interactions in Covid-19 Hospitalized Patients”, J. Sains. Kes, vol. 5, no. 5, pp. 559–567, Nov. 2024, doi: 10.30872/jsk.v5i5.441.

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