Formulasi dan Evaluasi Hidrogel Mukoadhesif Metronidazole Menggunakan Kombinasi Kitosan dan Natrium Karboksimetilselulosa
Keywords:
Metronidazole, Kitosan, Natrium Karboksimetilselulosa, Hidrogel, Desain FaktorialAbstract
References
Aziz. N. Peran Antagonis Reseptor H-2 Dalam Pengobatan Ulkus Peptikum. Sari Pediatri. 2002. 3: 222-266
Zhang.Y., Argent.R.H., Letley.D.P., Thomas.R.J. and Atherton.J.C. Tyrosine phosphorylationof CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelium cells, J. Clin. Microbiol. 2005. 43: 786-790
Farida,A., Unita,M., Yulianita, F., Azhar.M.B., Yuwono. Sensitifitas dan Spesifisitas Pemeriksaan Helicobacter pylori pada Saliva Penderita Gastritis Kronik dengan PCR. Fakultas Kedokteran Universitas Sriwijaya. Palembang. 2008: 1-14
Arora.S., Bisen.G., Budhiraja.R.D. Mucoadhesive and Mucopenetrating Delivery Systems for Eradication of Helicobacter pylory. Asian. J. Pharm. 2012. 6:18-30
Torre PM, Enobakhare Y, Torrado G and Torrado S. Release of amoxicillin from polyionic complexes of chitosan and poly (acrylic acid), study of polymer/polymer and polymer/drug interaction within the network structure. Biomaterials.2003. 24:1499-1506
Lacy.Cf., Amstrong L.L., Goldman.M.P., Lance.L.L. Drug Information Handbook. 1st Edition. American Pharmacist Association. USA. 2009: 1126-1127
Redisuire.C.F., Porta.V., Nunes.D.S.G., Nunes.T.M., Junginger.H.E., Kopp.S., Midha.K.K., Shah.V.P., Stavchansky.J.B., Barend.D.M. Biovaiwer Monograph for Immediate Release Solid Oral Dosage Form: Metronidazole. J. Pharm. Sci. 2011. 100: 1618-1627
Tangri.P., Madhav1. N.V.S. Oral Mucoadhesive Drug Delivery Systems. Int.l J. Biopharm. 2011. 2: 36-46
Gupta.A.K., Maurya.S.D., Dhakar.R.C., Singh.R.D. pH-Sensitive Interpenetrating Hydrogel for Eradication of Helicobacter Pylori. Int. J. Pharm. Sci. Nanotech.2010. 3: 924-932
Abu-Jdayil B, Fara DA. Modification of the Rheological Behaviour of Sodium Alginate by Chitosan and Multivalent Electrolytes. Ital. J. Food Sci. 2013. 25 : 196-201.
Santoso.I.L. 2013. Preparasi dan Evaluasi Hidrogel Natrium Diklofenak dengan Kitosan dan Natrium Alginat. Skripsi. Universitas Widya Mandala. 2013 :44-47
He.H. Multifunctional Medican Device Based on pH-Sentitive Hydrogels for Controlled Drug Delivery. Disertation. The ohio Universtity. 2006: 57-59
DEPKES RI. Farmakope Indonesia. Edisi IV. DEPKES RI. Jakarta. 1995 : 1066
Rajput GC, Majmudar FD, Patel JK, Patel KN., Thakor RS, Patel BP, Rajgor NB. Stomach Spesific Mucoadhesive Tablet as Controlled Drug Delivery System, Review Article. Int. J. Pharm. Bio Res. 2010. 1: 30-41.
Lin YH, Liang HF, Chung CK, Chen MC, Sung HW. Physically Crosslinked Alginate/N,O Carboxymethyl Chitosan Hydrogels with Calcium for Oral Delivery of Protein Drugs. Biomaterials. 2005. 26: 2105–2113.
Déat-Lainé E, Valérie H, Ghislain G, Jean-Francois J, Jean-Michel C, Muriel S, Eric B. Efficacy of Mucoadhesivve Hydrogel Microparticles of WhyeProtein and Alginate for Oral Insulin Delivery. Pharm. Res. 2013. 30: 721-734.
MengX,LiP,WeiQ,ZhangHX. pH Sensitive Alginate-Chitosan Hydrogel Beadsfor Carvedilol Delivery. Pharm Dev Tech.2011; 16(1): 22-28.
Hoffman AS. Hydrogels for Biomedical Application, ReviewArticle. Adv Drug Deliv. 2002; 43(5):3-12.
Deacon, M. P., Clive J. R., Phillip M. W., Saul J. B. T., Martyn C. D., S. S. (Bob) DAVIS and Stephen E. H2000. Atomic Force Microscopy Of Gastric Mucin and Chitosan Mucoadhesive Systems. Biochem. J. 2000. 348: 557-563
El-Kamel, A.H., Sokar, M.S., Naggar, V.F., and Gamal, S.A . Bioadhesive Controlled Release Metronidazol Vaginal Tablets. Acta Pharm. 2002. 52:171-179
Komariah.E. Pengembangan Granul Mukoadhesif Diltiazem Tertahan Di Lambung Menggunakan Eksipien Koproses Karagenan dan Pragelatinasi Pati Singkong Propionat.Tesis.UI.2012.
Setiaastuti.A.D., Preparasi Dan Karakterisasi Kitosan Suksinat Sebagai Matriks Pada Granul Lepas Lambat Mukoadhesif. Skripsi. UI. 2011.`
