Analysis of Platelet Count on Liver Cirrhosis Patients Based on Child-Pugh Classification

Penulis

  • Renanda Maulidya Fadyla Univeristas Mulawarman Penulis
  • Rahmat Bakhtiar Department of Public Health, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia Penulis
  • RR. Ignatia Sinta Murti Department of Internal Medicine, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia Penulis

Kata Kunci:

cirrhosis, platelets, Child-Pugh

Abstrak

Liver cirrhosis is described as a diffused pathological process which marked with fibrosis and architectural changes of normal liver that becomes an abnormal nodular structure. Liver cirrhosis is caused by chronic liver disease of virus nor non virus. Thrombocytopenia is a hematology abnormality which frequently found on liver cirrhosis patients. Severity level and prognosis of liver cirrhosis can be determined by Child-Pugh classification. This research aims to know the difference of mean platelet count on liver cirrhosis patients based on Child-Pugh classification. It applied analytic observational method with cross-sectional design. The data was taken from medical records of patients at Abdul Wahab Sjahranie Hospital in Samarinda of 2018-2020 period. Statistical analysis was using Kruskal-Wallis test. The results showed liver cirrhosis patients in Child-Pugh C is at most. Mean platelet count of liver cirrhosis with Child-Pugh A is 73.250/?l, Child-Pugh B is 126.370/?l, and Child-Pugh C is 148.375/ ?l. Based on statistical test, the score p = 0,19 (p > 0,05), there are no differences of mean platelet count among the three Child-Pugh classifications.

Referensi

1. Mc Cance KL, Huether SE. Pathophysiology?: The Biologic Basis For Disease In Adults and Children. 7th ed. Elsevier; 2014.

2. Kumar V, Abbas AK, Aster JC. Buku Ajar Patologi Robbins. 9th ed. Singapura: Elsevier Saunders; 2015.

3. Nurdjanah S. Sirosis Hepatis. In: Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: InternaPublishing; 2014. p. 1980–5.

4. World Health Organization. The Global Burden of Disease 2010 [Internet]. 2010. Available from: www.who.int

5. Wolf DC. Cirrhosis [Internet]. 2018. Available from: emedicine.medscape.com

6. World Health Organization. Global Health Estimates 2016: Disease burden by Cause, Age, Sex, by Country and by Region, 2000-2016 [Internet]. 2018. Available from: www.who.int

7. World Health Organization. Liver cirrhosis (15+), age-standardized death rates by country [Internet]. 2018. Available from: www.who.int

8. Bacon BR. Cirrhosis and Its Complications. In: Harrison’s Principles of Internal Medicine. 19th ed. Mc Graw Hill Education; 2015. p. 2058–67.

9. Peck-Radosavljevic M. Thrombocytopenia in chronic liver disease. Liver Int. 2017;37(6):778–93.

10. Sigal S, Mitchell O, Feldman D, Diakow M. The pathophysiology of thrombocytopenia in chronic liver disease. Hepatic Med Evid Res. 2016;39.

11. Moore AH. Thrombocytopenia in Cirrhosis?: A Review of Pathophysiology and Management Options. Am Assoc Study Liver Dis. 2019;14(5):183–6.

12. Osada M, Kaneko M, Sakamoto M, Endoh M, Takigawa K, Suzuki-inoue K, et al. Causes of Thrombocytopenia in Chronic Hepatitis C Viral Infection. SAGE Journals [Internet]. 2012;18(3):272–80. Available from: https://doi.org/10.1177/1076029611429124

13. Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, et al. Platelet count for predicting fibrosis in nonalcoholic fatty liver disease. J Gastroenterol. 2011;46(11):1300–6.

14. Tsoris A, Marlar CA. Use Of The Child Pugh Score In Liver Disease [Internet]. StatPearls. 2019. p. 14–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31194448

15. Al Hijjah F, Yaswir R, Syah NA. Gambaran Jumlah Trombosit Berdasarkan Berat Ringannya Penyakit pada Pasien Sirosis Hati dengan Perdarahan di RSUP Dr. M. Djamil Padang. J Kesehat Andalas [Internet]. 2017;6(3):609–14. Available from: http://jurnal.fk.unand.ac.id

16. Nwokediuko SC, Ibegbulam O. Quantitative Platelet Abnormalities in Patients With Hepatitis B Virus-Related Liver Disease. Elmer Press. 2009;2(6):344–9.

17. Erdem MG, Çil EÖ, Tükek T, Helvac? ?A. Evaluation of platelet and mean platelet volume levels in patients with liver cirrhosis. Arch Clin Exp Med. 2018;3(1):18–21.

18. Lovena A, Miro S, Efrida E. Karakteristik Pasien Sirosis Hepatis di RSUP Dr. M. Djamil Padang. J Kesehat Andalas. 2017;6(1):5.

19. Saksana RA, Bayupurnama P, Indrarti F, Ratnasari N, Maduseno S, Triwikatmani C, et al. Correlation between the Severity of Liver Cirrhosis ( Child-Pugh Score ) and QTc Interval Prolongation. Indones J Gastroenterol Hepatol Dig Endosc. 2012;13(3):157–60.

20. D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies. J Hepatol. 2006;44(1):217–31.

21. Hutahaean R, Ali HR, Loho E. Hubungan Gambaran USG Pada Penderita Sirosis Hati dengan Fibrosis Skor di Bagian Radiologi RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013 – Desember 2013. J E-Clinic. 2014;2(1):1–9.

22. Husni N, Anniwati L, Lukitasari L. Aspartate Aminotransferase to Platelet Ratio Index Profile of Cirrhotic Patients with Positive HBsAg. JUXTA J Ilm Mhs Kedokt Univ Airlangga. 2019;10(1):34.

23. Klein SL. Sex influences immune responses to viruses, and efficacy of prophylaxis and therapeutic treatments for viral diseases. NIH Public Access. 2014;34(12):1050–9.

24. Moinuddin A, Goel A, Saini S, Bajpai A, Misra R. Alcohol Consumption and Gender?: A Critical Review. J Psychol Psychother. 2016;6(3).

25. Tambunan A, Mulyadi Y, Kahtan MI. Characteristics of Cirrhotic Patients in Dr. Soedarso General Hospital Pontianak Periods of January 2008-December 2010. Neliti-Repositori Ilm Indones [Internet]. 2013;1–19. Available from: neliti.com

26. Patasik YZ, Waleleng BJ, Wantania F. Profil Pasien Sirosis Hati Yang Dirawat Inap di RSUP Prof .Dr.R.D.Kandou Manado Periode Agustus 2012-Agustus 2014. J E-Clinic. 2015;3:342–7.

27. Meri, Nurismayanti R. Gambaran Pemeriksaan Darah Rutin Terhadap Penderita Sirosis Hati. e-Jurnal STIKes Bakti Tunas Husada Tasikmalaya. 2018;1:155–9.

28. Saragih GG, Waleleng BJ, Harlinda H. Gambaran gangguan hemostasis pada penderita sirosis hati yang dirawat di RSUP Prof.Dr.R. D.Kandou periode Agustus 2013 – Agustus 2015. J e-Clinic. 2016;4:4–9.

29. Hancox SH, Smith BC. Liver disease as a cause of thrombocytopenia. QJM An Int J Med. 2013;(January):425–31.

30. Djordjevic J, Svorcan P, Vrinic D, Dapcevic B. Splenomegaly and thrombocytopenia in patients with liver cirrhosis. Vojnosanit Pregl. 2010;67(2):166–9.

31. Hassan H, Ansari AK, Memon SF. Haemostatic Abnormalities in Patients with Cirrhosis and their Relation with Severity of Liver Dysfunction as Assessed by Child Pugh Score. J Liaquat Univ Med Heal Sci. 2017;16(2):108–13.

32. Adinolfi LE, Giordano MG, Andreana A, Tripodi MF, Utili R, Cesaro G, et al. Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis. Br J Haematol. 2001;113(3):590–5.

33. Shao L, Zhang S, Wang N, Yu W, Chen M, Xiao N, et al. Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS One [Internet]. 2020;1–9. Available from: http://dx.doi.org/10.1371/journal.pone.0227544

34. Ikura Y, Ohsawa M, Okada M, Iwai Y, Wakasa K. The Significance of Platelet Consumption in the Development of Thrombocytopenia in Patients With Cirrhosis. Am J Med Sci. 2013;346(3):199–203.

35. Shimizu E, Murohisa G, Koide S, Yoshimi T, Nakamura H, Ohno R. Serum Thrombopoietin Levels in Patients With Chronic Hepatitis and Liver Cirrhosis. Am J Gastroenterol. 1999;94(7):2–6.

36. Aref S, Mabed M, Selim T, Goda T, Khafagy N. Thrombopoietin ( TPO ) Levels in Hepatic Patients with Thrombocytopenia. Taylor Fr Heal Sci. 2004;9(5/6):351–6.

37. Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H. Management of thrombocytopenia due to liver cirrhosis?: A review. World J Gastroenterol. 2014;20(10):2595–605.

38. Kuo YH, Kee KM, Hsu NT, Wang JH, Hsiao CC, Chen Y, et al. Using AST-platelet ratio index and fibrosis 4 index for detecting chronic hepatitis C in a large-scale community screening. PLoS One. 2019;14(10):1–11.

39. Assinger A. Platelets and infection - An emerging role of platelets in viral infection. Front Immunol. 2014;5:10–2.

40. Ikarashi Y, Kodama K, Taniai M. The Clinical Difference in the Platelet Counts between Liver Cirrhosis with Nonalcoholic Fatty Liver Disease and Hepatitis C Virus. Intern Med J. 2018;57(8):1065–1070.

41. Tejima K, Masuzaki R, Ikeda H, Yoshida H. Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly. J Gastroenterol. 2010;45:876–84.

42. Das SK, Mukherjee S, Vasudevan DM, Balakrishnan V. Comparison of haematological parameters in patients with non-alcoholic fatty liver disease and alcoholic liver disease. Singapore Med J. 2011;52(3):175–81.

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Diterbitkan

2021-08-31

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Articles

Cara Mengutip

Analysis of Platelet Count on Liver Cirrhosis Patients Based on Child-Pugh Classification. (2021). Jurnal Sains Dan Kesehatan, 3(4), 404–410. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/266