Polimorfisme Gen DRD2 rs1799732 (-141c) Terhadap Terapi Aripiprazole pada Pasien Skizofrenia

Polymorphism Gene DRD2 rs1799732 (-141c) Against Aripiprazole Therapy In Schizophrenia Patients

Penulis

  • Fitri Program Studi Magister Ilmu Biomedik Fakultas Kedokteran, Universitas Sriwijaya Jalan Raya Palembang-Prabumulih Km. 32 Inderalaya, Ogan Ilir, Sumatera Selatan, 30662 Penulis
  • Irsan Saleh Bagian Farmakologi Kedokteran Fakultas Kedokteran, Universitas Sriwijaya Jalan Raya Palembang-Prabumulih Km. 32 Inderalaya, Ogan Ilir, Sumatera Selatan, 30662 Penulis
  • Theodorus Bagian Farmakologi Kedokteran Fakultas Kedokteran, Universitas Sriwijaya Jalan Raya Palembang-Prabumulih Km. 32 Inderalaya, Ogan Ilir, Sumatera Selatan, 30662 Penulis

Kata Kunci:

polymorphism, DRD2, aripiprazole, schizophrenia

Abstrak

Polimorfisme rs1799732 (-141C)  terletak di wilayah promotor 5' dari DRD2, di mana SNP ini dapat mempengaruhi modulasi aktivitas transkripsi dan kepadatan reseptor D2. Penulisan ini bertujuan memberikan telaah pustaka mengenai polimorfisme Rs 1799732 (-141C) karena polimorfisme gen ini merupakan polimorfisme gen yang paling banyak dijumpai di seluruh dunia terkait kejadian skizofrenia. Polimorfisme gen ini diketahui berperan dalam variabilitas respons terapi antipsikotik aripiprazole pada pasien skizofrenia. Jenis telaah yang digunakan dalam artikel ini berbentuk literature review terhadap 38 literatur dari berbagai jurnal maupun textbook. Skizofrenia suatu penyakit dapat mempengaruhi otak. Pada otak terjadi proses penyampaian pesan secara kimiawi yang akan meneruskan pesan sekitar otak. Pada pasien skizofrenia, dopamin berlebihan, sedangkan kadar dopamin berperan penting pada perasaan senang dan pengalaman mood yang berbeda. Jika kadar dopamin tidak seimbang, penderita bisa mengalami gejala positif dan negatif. Hipotesis menyatakan bahwa aktivitas dopaminergik yang berlebihan bisa menimbulkan skizofrenia. Sistem dopaminergik berperanan penting sebagai modulator fungsi afektif dan kognitif. Polimorfisme reseptor dopamine D2 diketahui sebagai salah satu faktor risiko dari skizofrenia. Polimorfisme menjadi faktor penentu gejala klinis dan dapat berperan dalam efektivitas dan efek samping antipsikotik, termasuk aripiprazole . Aripiprazole adalah jenis antipsikotik generasi kedua, merupakan antipsikotik dengan aktivitas agonis parsial terhadap dopamin D2. 

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Unduhan

Diterbitkan

2024-11-14

Terbitan

Vol 4 No 2 (2022): J. Sains Kes.

Bagian

Review

Cara Mengutip

Polimorfisme Gen DRD2 rs1799732 (-141c) Terhadap Terapi Aripiprazole pada Pasien Skizofrenia: Polymorphism Gene DRD2 rs1799732 (-141c) Against Aripiprazole Therapy In Schizophrenia Patients. (2024). Jurnal Sains Dan Kesehatan, 4(2), 214–221. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/392