Potensi Senyawa Fitokimia pada Tumbuhan dalam Menurunkan Kadar Glukosa Darah pada Diabetes Melitus

Potential of Phytochemical Compounds in Plants in Lowering Blood Glucose Levels in Diabetes

Authors

  • Raymond Elbert Budianto Program Studi Sarjana Kedokteran Fakultas Kedokteran Universitas Udayana Author https://orcid.org/0000-0001-6889-1266
  • Ni Made Linawati Histology Department Faculty of Medicine Udayana University Author
  • I Gusti Kamasan Nyoman Arijana Departemen Histologi FK Unud Author
  • Ida Ayu Ika Wahyuniari Departemen Histologi FK Unud Author
  • I Gusti Nyoman Sri Wiryawan Departemen Histologi FK Unud Author

Keywords:

Diabetes melitus, fitokimia, glukosa darah

Abstract

Diabetes melitus adalah gangguan metabolik kronis yang ditandai dengan hiperglikemia atau tingginya glukosa dalam darah karena gangguan dalam sekresi maupun respons terhadap hormon insulin. Menurut data dari International Diabetes Federation, prevalensi diabetes melitus di seluruh dunia sudah sangat tinggi, yaitu 537 juta pada tahun 2021. Akan tetapi, sudah ada berbagai obat alternatif alami yang dapat digunakan untuk menangani penyakit tersebut. Dalam beberapa penelitian, banyak tanaman yang sudah teruji khasiatnya sebagai obat antidiabetes alami karena kandungan fitokimianya. Studi literature review ini dilakukan dengan pencarian data melalui Google Scholar dan Science Direct dalam kurun  waktu 10 tahun terakhir (2013-2022). Dari 29 artikel yang sesuai diperoleh hasil bahwa beberapa kandungan fitokimia pada tumbuhan seperti alkaloid dengan kemampuannya memperbaiki sel beta pankreas, flavonoid sebagai astringen, saponin dengan kemampuannya menstimulasi sekresi insulin dari sel beta pankreas, dan tanin sebagai antioksidan alami berpotensi menurunkan glukosa darah pada diabetes melitus tipe 1 dan 2.

References

Xiao Y, Zheng L, Zou X, Wang J, Zhong J, Zhong T, 2019. Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy. Vol. 8, no. 1, pp. 1625677.

Milita F, Handayani S, Setiaji B, 2021. Kejadian Diabetes Mellitus Tipe II pada Lanjut Usia di Indonesia (Analisis Riskesdas 2018). Jurnal Kedokteran dan Kesehatan. Vol. 17, no. 1, pp. 9-20.

Abd Elkader AM, Labib S, Taha TF, Althobaiti F, Aldhahrani A, Salem HM, Saad A, Ibrahim FM, 2021. Phytogenic compounds from avocado (Persea americana L.) extracts; antioxidant activity, amylase inhibitory activity, therapeutic potential of type 2 diabetes. Saudi Journal of Biological Sciences. Vol. 29, no. 3, pp. 1428-1433.

Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, Khare S, Srivastava A, 2020. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Vol. 14, No. 4, pp. 535-545.

Alam S, Hasan MK, Neaz S, Hussain N, Hossain MF, Rahman T, 2021. Diabetes Mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management. Diabetology. Vol. 2, no. 2, pp. 36-50.

Pippitt K, Li M, Gurgle HE, 2016. Diabetes Mellitus: Screening and Diagnosis. American Family Physician. Vol. 93, no. 2, pp. 103-109.

Herwin H, 2019. Variasi Ekstrak Etanol Biji Alpukat (Persea Americana Mill.) Pada Granul Effervecsent Sebagai Antidiabetes. Jurnal As-Syifaa Farmasi. Vol. 11, no.1, pp. 61-69.

Cole JB, Florez JC, 2020. Genetics of diabetes mellitus and diabetes complications. Nature Reviews Nephrology. Vol. 16, no. 7, pp. 377-390.

Webber S, 2021. International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice.

Glovaci D, Fan W, Wong ND, 2019. Epidemiology of diabetes mellitus and cardiovascular disease. Current cardiology reports. Vol. 21, no. 4, pp. 1-8.

Singh AK, Gupta R, Ghosh A, Misra A, 2020. Diabetes in COVID-19: Prevalence pathophysiology, prognosis and practical considerations. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Vol. 14, no. 4, pp. 303-310.

Forouhi NG, Wareham NJ, 2019. Epidemiology of diabetes. Medicine. Vol. 47, no. 1, pp. 22-27.

World Health Organization, 2019. Classification of Diabetes Mellitus.

Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka- Gantenbein C, 2018. Review on type 1 diabetes mellitus pathogenesis. Endocrine Connections. Vol. 7, no. 1, pp. R38-R46.

Fatimah RN, 2015. Diabetes melitus tipe 2. Jurnal Majority. Vol. 4, no. 5.

Bonora E, DeFronzo RA, 2018. Diabetes Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Springer.

Johns EC, Denison FC, Norman JE, Reynolds RM, 2018. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends in Endocrinology and Metabolism. Vol. 29, no. 11, pp. 743-754.

Eliana F, 2015. Penatalaksanaan DM Sesuai Konsensus Perkeni 2015. PB Perkeni Jakarta.

Soelistijo, Soebagijo Adi, 2021. Pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. Pb. Perkeni.

Yaribeygi H, Butler AE, Barreto GE, Sahebkar A, 2019. Antioxidative potential of antidiabetic agents: a possible protective mechanism against vascular complications in diabetic patients. Journal of cellular physiology. Vol. 234, no. 3, pp. 2436-2446.

Khursheed R, Singh SK, Wadhwa S, Kapoor B, Gulati M, Kumar R, Ramanunny AK, Awasthi A, Dua K, 2019. Treatment strategies against diabetes: Success so far and challenges ahead. European journal of pharmacology. Vol. 862, pp. 172625.

Dunlay SM, Givertz MM, Aguilar D, Allen LA, Chan M, Desai AS, Deswal A, Dickson VV, Kosiborod MN, Lekavich CL, McCoy RG, 2019. Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America. Circulation. Vol. 140, no. 7, pp. e294-e324.

Yendapally R, Sikazwe D, Kim SS, Ramsinghani S, Fraser?Spears R, Witte AP, La?Viola B, 2020. A review of phenformin, metformin, and imeglimin. Drug development research. Vol. 81, no. 4, pp. 390-401.

Lebovitz HE, 2019. Thiazolidinediones: the forgotten diabetes medications. Current diabetes reports. Vol. 19, no. 12, pp. 1-13.

Sujana D, Nurul N, Ramdani HT, 2019. Jurnal Review Aktivitas Antidiabetes dan Kandungan Senyawa Kimia dari Berbagai Bagian Tanaman Alpukat (Persea americana). Jurnal Medika Cendikia. Vol. 6, no. 1, pp. 76-81.

Adhikari B, 2021. Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus. Journal of Chemistry. Vol. 2021.

Bai L, Li X, He L, Zheng Y, Lu H, Li J, Zhong L, Tong R, Jiang Z, Shi J, Li J. Antidiabetic potential of flavonoids from traditional Chinese medicine: A review. The American journal of Chinese medicine. Vol. 47, no. 5, pp. 933-957.

Aba PE, Asuzu IU, 2018. Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants: A review. Indian Journal of Natural Products and Resources. Vol. 9, no. 2, pp. 85-96.

Malik B, 2018. Pengaruh Frekuensi Pemberian Jus Sargassum Sp. Terhadap Penurunan Kadar Glukosa Darah Dan Peningkatan Tnf-? Pada Mata Dan Otak Tikus Diabetes Mellitus Tipe 2. Universitas Brawijaya.

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Published

2022-10-31

Issue

Vol. 4 No. 5 (2022): J. Sains Kes.

Section

Review

How to Cite

Potensi Senyawa Fitokimia pada Tumbuhan dalam Menurunkan Kadar Glukosa Darah pada Diabetes Melitus: Potential of Phytochemical Compounds in Plants in Lowering Blood Glucose Levels in Diabetes. (2022). Jurnal Sains Dan Kesehatan, 4(5), 548–556. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/557

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