Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia

Authors

  • Abror Rahman Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Author
  • Ifana Mahardika Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Author
  • Ratih Dewi Saputri Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Author
  • Tjitjik Srie Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Author
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Author

Keywords:

Melicope quercifolia, pakipodol, ayanin, antioksidan

Abstract

Dua senyawa turunan kuersetin, pakipodol (1) dan ayanin (2) telah diisolasi dari kulit batang Melicope quercifolia (B.S. William) Ridl. Struktur kedua senyawa turunan kuersetin ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antioksidan senyawa 1–2 terhadap radikal DPPH memperlihatkan IC50 254 ± 10 dan 38,55 ± 0,02 μg/mL.

References

[1] Saputri, R.D., Tjahjandarie, T.S., Tanjung, M., 2019. Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope quercifolia. Nat. Prod. Res., 1-6, https://doi.org./10.1080/14786419.2019.1644634

[2] Kasim, N.K., Rahmani, M., Ismail, A., Sukari, M.A., Ee, G.C.L., Nasir, N.M., Awang, K., (2013). Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae). Food Chem. 139, 87-92.

[3] Saputri, R.D., Tanjung, M., Tjahjandarie, T.S., (2018a). Cytotoxic activity of quinolinone alkaloids and acylphloroglucinol from the leaves of Melicope denhamii. J. of Physics: Conference Series.1095(1), 012031.

[4] Tjahjandarie, Saputri, R.D., Wahjoedi, R.A., Tanjung, M., (2018). Melimoluccanin, a new isoprenylated quinolone alkaloid from the leaves of Melicope moluccana TG Hartley. J. of Physics: Conference Series.1095(1), 012042.

[5] Saputri, R.D., Tjahjandarie, T.S., Tanjung, M., (2018b). Meliglabrin, a new flavonol derivative from the leaves of Melicope glabra (Blume) TG Hartley. Nat. Prod. Sci.24(3), 155-158.

[6] Simonsen, H,T., Adersen, A., Bremmer, P., Heinrich, M., Smitt, U.W., Jaroszewski, J,W., (2004). Antifungal constituents of Melicope borbonica, Phytother. Res. 18, 542-545.

[7] Marliana, E., Tjahjandarie, T.S., Tanjung, M., (2016). Aktivitas antioksidan senyawa flavonoid dari Macaranga pearsonii Merr. J. Kimia Mulawarman. 13(2), 97-100.

[8] Khasanah, S.N.N.,Imaniah, N., Saputri, R.D., Tjahjandarie, T.S., Tanjung, M., (2018), Kumarin terisoprenilasi dan alkaloid indol dari kulit batang Zanthoxylum ovalifolium Tutcher. J. Kimia Mulawarman. 15(2), 76-81.

[9] Tjahjandarie, T.S., Saputri, R.D., Tanjung, M., (2016). Oxygeranylated coumarins from the root of Limonia accidisima L. and their DPPH radical scavenging activity. Der Pharmacia Lettre. 8, 33-36.

[10] Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., (2016). Antimalarial and antioxidant of isoprenylated coumarins from the stem bark of Mesua borneensis L. J Biol. Active Prod from Nature. 6, 95-100.

[11] Tanjung M, Mujahidin D, Hakim EH, Darmawan A, Syah Y.M. (2010). Geranylated flavonols from Macaranga rhizinoides. Nat Prod Commun. 5,1209-1211.

[12] Ali, H.A., Chowdhury, A.K.A., Rahman, A.K.M., Borkowski, T., Nahar, L., Sarker, S.D., (2008). Pachypodol, a flavonol from the leaves of Calycapteris floribunda, inhibits the growth of colon cancer cell line in vitro, Phytother. Res.22, 1684–1687.

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Published

2024-11-14

Issue

Vol. 2 No. 4 (2020): J. Sains Kes.

Section

Articles

How to Cite

[1]
A. Rahman, I. Mahardika, R. D. Saputri, T. S. Tjahjandarie, and M. Tanjung, “Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia”, J. Sains. Kes, vol. 2, no. 4, pp. 413–417, Nov. 2024, Accessed: Sep. 19, 2025. [Online]. Available: http://jsk.ff.unmul.ac.id/index.php/JSK/article/view/227

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