Profil Aktivitas Enzim Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), dan Alanine Transaminase (ALT) Pada Tikus Hiperlipidemia yang Diberi Madu Fermentasi Bawang Tunggal

Authors

  • Devyana Dyah Wulandari Universitas Nahlatul Ulama Surabaya Author
  • Suprapto Ma'at Department of Medical Laboratory Technology, Faculty of Health Author
  • Lysa Veterini Department of Medicine, Faculty of Medicine Author
  • Devi Fitriana Sari Department of Medical Laboratory Technology, Faculty of Health Author
  • Devyani Diah Wulansari Department of Medicine, Faculty of Medicine Author

DOI:

https://doi.org/10.30872/jsk.v6i1.636

Keywords:

Hiperlipidemia, Madu fermentasi, ALP, AST, ALT, Diet tinggi lemak

Abstract

Madu terfermentasi dengan bawang putih telah diketahui memiliki kandungan senyawa fenolat yang tinggi. Penelitian ini bertujuan untuk mengetahui efek suplementasi madu fermentasi terhadap profil aktivitas enzim Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), dan Alanine Transaminase (ALT) pada Tikus Hiperlipidemia.  Penelitian ini menggunakan 24 ekor tikus jantan dengan berat badan 200-250 dibagi menjadi 6 kelompok yaitu kontrol negatif, kontrol positif, P1 yang diberi madu fermentasi dosis 0,2 mg/kg BB/hari, kelompok P2 yang diberi madu fermentasi dosis 0,5 mg/kg BB/hari, kelompok P3 yang diberi madu fermentasi dosis 1 mg/kg BB/hari dan kelompok P4 yang diberi simvastatin dosis 1.008 g/l. Kadar ALP, AST, dan ALT serum diukur dengan fotometer. Hasil penelitian menunjukkan nilai signifikansi ALP p=0,152, AST p=0,839, dan ALT p=0,025 dengan p<0,05. Dapat disimpulkan bahwa kadar ALP dan AST yang diberikan madu fermentasi tidak memberikan pengaruh yang signifikan, sedangkan kadar ALT yang diberikan madu fermentasi memberikan pengaruh yang signifikan.

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Published

2025-05-31

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Vol. 6 No. 1 (2025)

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How to Cite

[1]
D. Dyah Wulandari, S. Ma'at, L. Veterini, D. F. Sari, and D. D. Wulansari, “Profil Aktivitas Enzim Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), dan Alanine Transaminase (ALT) Pada Tikus Hiperlipidemia yang Diberi Madu Fermentasi Bawang Tunggal”, J. Sains. Kes, vol. 6, no. 1, pp. 51–58, May 2025, doi: 10.30872/jsk.v6i1.636.

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