Histopatologi Hati Mencit (Mus Musculus) yang Diberikan Minuman Ringan Berkarbonasi dan Ekstrak Daun Kersen (Muntingia Calabura L.): Liver Histopathology of Mice (Mus Musculus) Induced by Carbonated Soft Drink and Kersen Leaves Extract (Muntingia Calabura L.)

Muhammad Nuzul Azhim Ash Siddiq; Chaidir Masyhuri Majiding; Fahrul Rozi; Wiwin Winarsih

doi:10.30872/jsk.v6i2.124

Authors

Muhammad Nuzul Azhim Ash Siddiq Program Studi Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Chaidir Masyhuri Majiding Program Studi Gizi, Fakultas Kesehatan Masyarakat, Universitas Mulawarman, Samarinda, Indonesia Author
Fahrul Rozi Program Studi Farmasi Klinis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Wiwin Winarsih Divisi Patologi Veteriner IPB, Fakultas Kedokteran Hewan, Institut Pertanian Bogor, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v6i2.124

Keywords:

Hepar, Histopatologi, Kersen, Mencit, Carbonated Soft Drink

Abstract

Konsumsi minuman berkarbonasi/ carbonated soft drink (CSD) yang berlebih berisiko menyebabkan terjadinya sindrom metabolik, obesitas, berbagai penyakit kronis, dan kerusakan organ. Kersen berpotensi mencegah dan mengurangi kerusakan pada hati yang disebabkan oleh CSD. Penelitian ini bertujuan untuk melihat gambaran histopatologi hati mencit yang diberikan minuman CSD dan efek pemberian ekstrak daun kersen. Penelitian experimental ini menggunakan rancangan acak lengkap dengan 25 mencit putih jantan yang dibagi 5 kelompok yaitu kelompok kontrol (K), kontrol negatif (N), perlakuan 1, 2, dan 3 dengan dosis (35 mg/30g BB, 45 mg/30g BB, 65 mg/30g BB) selama 30 hari. Sampel diterminasi pada hari ke 31 dan organ hepar dibuat preparat untuk diamati gambaran mikroskopis hati. Uji analisis menggunakan uji beda ANOVA dengan uji lanjut Duncan’s multiple-range test. Hasil pengamatan menunjukkan bahwa kelompok kontrol negatif memiliki jumlah kerusakan sel hati yang signifikan lebih rendah dibandingkan dengan kontrol positif yang diberikan CSD (p<0.05) dan kelompok perlakuan 2 dan 3 juga signifikan memiliki jumlah kerusakan sel yang lebih sedikit dibandingkan kelompok kontrol positif serta tidak berbeda signifikan dengan kelompok kontrol negatif. Ekstrak daun kersen memberikan pengaruh terhadap pencegahan dan mengurangi kerusakan sel hati pada mencit putih yang diberikan CSD.

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Histopatologi Hati Mencit (Mus Musculus) yang Diberikan Minuman Ringan Berkarbonasi dan Ekstrak Daun Kersen (Muntingia Calabura L.)

Liver Histopathology of Mice (Mus Musculus) Induced by Carbonated Soft Drink and Kersen Leaves Extract (Muntingia Calabura L.)

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