Peranan Sel Limfosit Dalam Imunulogi: Artikel Review

Authors

Keywords:

Limfosit, Imunologi, Imunitas Adaptif

Abstract

Limfosit ditemukan dalam darah dan limfonodi. Selain sel Natural Killer (NK), sel T dan sel B adalah berbagai bentuk limfosit. Masing-masing sel ini memainkan peran mendasar dalam respons imun adaptif tubuh. Sel B berperan penting dalam respon imun, secara resmi dikenal sebagai prekursor sel penghasil antibodi: sel plasma. Penemuan dewasa ini menunjukkan bahwa peran sel B lebih jauh dari sekedar menghasilkan antibodi. Terdapat berbagai sub tipe sel limfosit B yang berbeda dengan peran yang berbeda, baik pada respon innate maupun adaptif, yang mencakup pengenalan antigen, pemrosesan, dan penyajiannya pada sel T, serta produksi sitokin yang berdampak dan memodulasi respons terhadap patogen. Secara klasik, telah dipertimbangkan bahwa limfosit B tidak memiliki kemampuan fagositik yang memungkinkan mereka untuk menginternalisasi, memproses, atau bahkan terinfeksi oleh patogen bakteri. Berdasarkan informasi terbaru, ditunjukkan bahwa sel B dapat dengan mudah terinfeksi oleh bakteri patogen dan bereaksi terhadap infeksi tersebut. Sel T berperan dalam respon imun sitotoksik. Sel T termasuk dalam sistem imun adaptif dan melakukan beragam fungsi dalam regulasi imun, peradangan, serta respons imun protektif. Dalam beberapa tahun terakhir, telah ditunjukkan bahwa sel T pada dasarnya terlibat di seluruh spektrum fisiologi dan patologi jaringan, tidak hanya dalam reaksi atau penyakit yang dianggap sebagai respon imunologis tulen, tetapi juga, mengutip beberapa contoh, terlibat dalam metabolisme, perbaikan jaringan, disbiosis, dan kehamilan. Penelitian dasar pada sel T juga merupakan cikal bakal yang melahirkan era baru imunoterapi yang melibatkan banyak peneliti dalam menemukan obat untuk kanker. Ulasan artikel ini bertujuan untuk lebih memahami temuan terbaru mengenai pembentukan dan mekanisme kerja limfosit, terutama pada sistem
imunitas adaptif. Pada artikel review ini dijelaskan berbagai bentuk limfosit dan peran imunomodulatornya
dalam kesehatan dan penyakit.

References

O. Orakpoghenor, D. O. Avazi, T. P. Markus, and O. S. Olaolu, “Lymphocytes : A Brief Review -,” vol. 3, no. June, pp. 4–8, 2019.

G. Rosario-p, “The development of B lymphocytes Introduction,” Universiteit Utrecht, 2009.

Y. Dachlan, “Immune System. Course Material. Doctoral Program,” Faculty of Medicine : Airlangga University, 2019.

M. D. Cooper and J. F. A. P. Miller, “Discovery of 2 Distinctive Lineages of Lymphocytes, T Cells and B Cells, as the Basis of the Adaptive Immune System and Immunologic Function: 2019 Albert Lasker Basic Medical Research Award,” JAMA - Journal of the American Medical Association, vol. 322, no. 13. pp. 1247–1248, 2019.

J. I. Castañeda-sánchez, A. Rosa, M. Duarte, M. L. Domínguez-lópez, J. J. De Cruz-lópez, and J. Luna-herrera, “Lymphocyte Updates - Cancer, Autoimmunity and Infection,” Lymph. Updat. - Cancer, Autoimmun. Infect., 2017, doi: 10.5772/66613.

N. Baumgarth, J. W. Tung, and L. A. Herzenberg, “Inherent specificities in natural antibodies: A key to immune defense against pathogen invasion,” Springer Seminars in Immunopathology, vol. 26, no. 4. pp. 347–362, 2005.

K. Hayakawa, R. R. Hardy, L. A. Herzenberg, and L. A. Herzenberg, “Progenitors for Ly-1 b cells are distinct from progenitors for other b cells,” J. Exp. Med., vol. 161, no. 6, pp. 1554–1568, 1985.

N. Baumgarth, “The double life of a B-1 cell: Self-reactivity selects for protective effector functions,” Nat. Rev. Immunol., vol. 11, no. 1, pp. 34–46, 2011.

N. Solvason et al., “Cyclin d2 is essential for BCR-mediated proliferation and CD5 B cell development,” Int. Immunol., vol. 12, no. 5, pp. 631–638, 2000.

E. Montecino-Rodriguez and K. Dorshkind, “B-1 B Cell Development in the Fetus and Adult,” Immunity, vol. 36, no. 1, pp. 13–21, 2012, doi: 10.1016/j.immuni.2011.11.017.

M. Y. Chou et al., “Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans,” J. Clin. Invest., vol. 119, no. 5, pp. 1335–1349, 2009.

L. Kulik et al., “Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury,” J. Immunol., vol. 182, no. 9, pp. 5363–5373, 2009.

F. Martin, A. M. Oliver, and J. F. Kearney, “Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens,” Immunity, vol. 14, no. 5, pp. 617–629, 2001.

N. Baumgarth, “The double life of a B-1 cell: Self-reactivity selects for protective effector functions,” Nat. Rev. Immunol., vol. 11, no. 1, pp. 34–46, 2011.

Y. S. Choi and N. Baumgarth, “Dual role for B-1a cells in immunity to influenza virus infection,” J. Exp. Med., vol. 205, no. 13, pp. 3053–3064, 2008.

K. Suzuki, M. Maruya, S. Kawamoto, and S. Fagarasan, “Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity,” Immunological Reviews, vol. 237, no. 1. pp. 180–190, 2010.

L. A. De-Gennaro, A. F. Popi, S. R. de Almeida, J. D. Lopes, and M. Mariano, “B-1 cells modulate oral tolerance in mice,” Immunol. Lett., vol. 124, no. 2, pp. 63–69, 2009.

C. H. Kim, “B cell-helping functions of gut microbial metabolites,” Microb. Cell, vol. 3, no. 10, pp. 529–531, 2016.

P. Shen et al., “IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases,” Nature, vol. 507, no. 7492, pp. 366–370, 2014.

U. M. Selvaraj, K. Poinsatte, V. Torres, S. B. Ortega, and A. M. Stowe, “Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair,” Neurotherapeutics, vol. 13, no. 4. pp. 729–747, 2016.

[K. A. Young, X. S. Chen, V. M. Holers, and J. P. Hannan, “Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21),” J. Biol. Chem., vol. 282, no. 50, pp. 36614–36625, 2007.

O. L. Hatton, A. Harris-Arnold, S. Schaffert, S. M. Krams, and O. M. Martinez, “The interplay between Epstein-Barr virus and B lymphocytes: Implications for infection, immunity, and disease,” Immunol. Res., vol. 58, no. 2–3, pp. 268–276, 2014.

U. C. Meier, G. Giovannoni, J. S. Tzartos, and G. Khan, “Translational Mini-Review Series on B cell subsets in disease. B cells in multiple sclerosis: Drivers of disease pathogenesis and Trojan horse for Epstein-Barr virus entry to the central nervous system?,” Clinical and Experimental Immunology, vol. 167, no. 1. pp. 1–6, 2012.

K. Nothelfer, P. J. Sansonetti, and A. Phalipon, “Pathogen manipulation of B cells: The best defence is a good offence,” Nature Reviews Microbiology, vol. 13, no. 3. pp. 173–184, 2015.

Y. Souwer et al., “B Cell Receptor-Mediated Internalization of Salmonella : A Novel Pathway for Autonomous B Cell Activation and Antibody Production,” J. Immunol., 2009.

K. Kubelkova and Z. Krocova, “the Role of B Cells in Intracellular,” in B cells: Molecular Biology, Developmental Origin and Impact on the Immune System, Cell Biolo., no. October, L. R. Robert L. Montes, Ed. Nova Science Publishers, 2013, pp. 1–43.

C. A. J. Vosshenrich, A. Cumano, W. Müller, J. P. Di Santo, and P. Vieira, “Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment,” Proc. Natl. Acad. Sci. U. S. A., vol. 101, no. 30, pp. 11070–11075, 2004.

T. Nagasawa, “Microenvironmental niches in the bone marrow required for B-cell development,” Nature Reviews Immunology, vol. 6, no. 2. pp. 107–116, 2006.

D. C. Hargreaves et al., “A coordinated change in chemokine responsiveness guides plasma cell movements,” J. Exp. Med., vol. 194, no. 1, pp. 45–56, 2001.

M. R. Ehrenstein and C. A. Notley, “The importance of natural IgM: Scavenger, protector and regulator,” Nature Reviews Immunology, vol. 10, no. 11. pp. 778–786, 2010.

H. De Haard, “The Development of B Lymphocytes,” Universiteit Utrecht, 2010.

A. P. Immunopaedia, Bellanti JA, Taylor, “Overview of T Cell Subsets,” Basics Immune Syst., 2017.

Y. Chien, C. Meyer, and M. Bonneville, “ γδ T Cells: First Line of Defense and Beyond ,” Annu. Rev. Immunol., vol. 32, no. 1, pp. 121–155, 2014.

E. J. Adams, Y. H. Chien, and K. C. Garcia, “Structure of a γδ T cell receptor in complex with the nonclassical MHC T22,” Science (80-. )., vol. 308, no. 5719, pp. 227–231, 2005.

Y. Cai et al., “Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation,” Immunity, vol. 35, no. 4, pp. 596–610, 2011.

M. Bonneville, R. L. O’Brien, and W. K. Born, “γ δ T cell effector functions: A blend of innate programming and acquired plasticity,” Nature Reviews Immunology, vol. 10, no. 7. pp. 467–478, 2010.

C. Nathan, “Neutrophils and immunity: Challenges and opportunities,” Nature Reviews Immunology, vol. 6, no. 3. pp. 173–182, 2006.

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Published

2024-11-14

Issue

Vol. 2 No. 4 (2020): J. Sains Kes.

Section

Review

How to Cite

[1]
F. R. Prakoeswa, “Peranan Sel Limfosit Dalam Imunulogi: Artikel Review”, J. Sains. Kes, vol. 2, no. 4, pp. 525–537, Nov. 2024, Accessed: Oct. 30, 2025. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/287

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