Hubungan Terapi Kombinasi Mood Stabilizer dan Antipsikotik dengan Kemampuan Fungsional Pasien Gangguan Afektif Bipolar di Rumah Sakit Jiwa Grhasia Yogyakarta

Relationship between Mood Stabilizer and Antipsychotic Combination Therapy with Functional Ability of Bipolar Affective Disorder Patients at Grhasia Mental Hospital Yogyakarta

Penulis

  • Nadia Utami Noor Universitas Ahmad Dahlan Penulis
  • Dyah Aryani Perwitasari Universitas Ahmad Dahlan Yogyakarta Penulis
  • Sawitri Sawitri Rumah Sakit Jiwa Grhasia Yogyakarta Penulis

Kata Kunci:

Bipolar, Functional abilities, Mood stabilizer, Antipsychotics

Abstrak

Gangguan bipolar merupakan gangguan jiwa yang dapat mempengaruhi kemampuan fungsional pasien. Gangguan bipolar bersifat persisten meski dalam kondisi eutimik. Telah banyak studi terkait efektivitas mood stabilizer dan antipsikotik pada gangguan bipolar, namun masih sedikit studi terkait efek kombinasi terapi mood stabilizer dan antipsikotik terhadap kemampuan fungsional pasien. Tujuan dari penelitian ini adalah untuk mengetahui hubungan pemberian kombinasi terapi mood stabilizer dan antipsikotik terhadap kemampuan fungsional pasien dengan gangguan bipolar afektif di Rumah Sakit Jiwa Grhasia Yogyakarta. Desain penelitian ini adalah kohort retrospektif. Data diperoleh dari rekam medis rawat inap RSJ Grhasia Yogyakarta periode Januari-Desember 2018. Sebanyak 46 pasien masuk dalam kriteria inklusi, 38 mendapat kombinasi terapi valproat + antipsikotik dan 8 mendapat kombinasi terapi litium + antipsikotik. Hasil menunjukkan bahwa tidak ada hubungan signifikan antara pemberian kombinasi mood stabilizer dan antipsikotik terhadap kemampuan fungsional pasien gangguan afektif bipolar [Odds Ratio (OR) = 1,71; 95% Confidence Interval(CI): 0,37 –7,95 ; p = 0,963)

Referensi

Kemenkes RI, Pedoman Nasional Pelayanan Kedokteran Jiwa. Jakarta: Kemenkes RI, 2015.

T. Vos et al., “Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013,” Lancet, vol. 386, no. 9995, pp. 743–800, 2015.

Kemenkes RI, HASIL UTAMA RISKESDAS 2018. Jakarta: Balitbangkes, 2018.

P. B. Mitchell, T. Slade, and G. Andrews, “Twelve-month prevalence and disability of DSM-IV bipolar disorder in an Australian general population survey,” Psychol. Med., vol. 34, no. 5, pp. 777–785, 2004.

Soumya P Thomas, A. Nisha, and P. J. Varghese, “Disability and quality of life of subjects with bipolar affective disorder in remission,” Indian J. Psychol. Med., vol. 38, no. 4, pp. 336–340, 2016.

Lambert PA, C. G, B. S, and C. S, “Neuropsychotropic action of a new anti-epileptic agent: depamide,” Ann Med Psychol, vol. 124, pp. 707–710, 1966.

K. Macritchie et al., “Valproate for acute mood episodes in bipolar disorder,” Cochrane Database Syst. Rev., vol. 2003, no. 1, 2003.

L. A. Smith, V. Cornelius, A. Warnock, M. J. Tacchi, and D. Taylor, “Acute bipolar mania: A systematic review and meta-analysis of co-therapy vs. monotherapy,” Acta Psychiatr. Scand., vol.115, no. 1, pp. 12–20, 2007.

American Psychriatric Association, “Practice guideline for the treatment of patients with bipolar disorder (revision),” Am. J. Psychiatry, vol. 159, no. 4, pp. 1–50, 2002.

Hubungan Terapi Kombinasi Mood Stabilizer dan Antipsikotik dengan Kemampuan Fungsional Pasien Gangguan Afektif Bipolar di Rumah Sakit Jiwa Grhasia YogyakartaJ.Sains Kes. 2021. Vol 3. No 5. p-ISSN:2303-0267, e-ISSN:2407-6082638

T. Miura et al., “Comparative effi cacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder:a systematic review and network meta-analysis,” The Lancet Psychiatry, vol. 1, no. 5, pp. 351–359, 2014.

M. G. Kang et al., “Lithium vs valproate in the maintenance treatment of bipolar I disorder:A post-hoc analysis of a randomized double-blind placebo-controlled trial,” Aust. New Zeal. J. Psychiatry, vol. 00, no. 0, pp. 1–10, 2019.

R. R. Kavitha, S. Kamalam, and R. P. Rajkumar, “Functional ability of clients with bipolardisorders in tertiary hospital, Puducherry,” Int. J. Community Based Nurs. Midwifery, vol. 6, no. 1, pp. 21–28, 2018.

M. Chen, H. M. Fitzgerald, J. J. Madera, and M. Tohen, “Functional outcome assessment in bipolar disorder: A systematic literature review,” Bipolar Disord., vol. 21, no. 3, pp. 194–214, 2019.

American Psychriatric Association, Diagnostic and Statistical Manual of Mental Disorder (DSM-IV-TR), Fourth Edi. Washington DC: American Psychiatric Association, 2000.[15]I. M. Aas, “Guidelines for ratingGlobal Assessment of Functioning (GAF),” Ann. Gen. Psychiatry, vol. 10, no. 1, p. 2, 2011.

L. M. Arnold, “Gender differences in bipolar disorder,” Psychiatr. Clin. North Am., vol. 26, no. 3, pp. 595–620, 2003.

I. M. Johan, Evaluasi Kerasionalan dan Kuantitas Penggunaan Kombinasi Obat Mood Stabilizer dan Antipsikotik pada Pasien Bipolar di Rumah Sakit Jiwa Grhasia Yogyakarta, Skripsi. Yogyakarta: Fakultas Farmasi Universitas Ahmad Dahlan, 2017.

A. Cipriani, K. Reid, A. H. Young, K. Macritchie, and J. Geddes, “Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder,” Cochrane Database Syst. Rev., vol. 2013, no. 10, 2013.

W. A. Nolen, “More robust evidence for the efficacy of lithium in the long-term treatment of bipolar disorder:should lithium (again)be recommended as the single preferred first-line treatment ?,” Int. J. Bipolar Disord., vol. 3, no. 1, pp. 1–3, 2015.

C. L. Bowden et al., “Efficacy of valproate versus lithium in mania or mixed mania:a randomized , open 12-week trial,” Int. Clin. Psychopharmacol., vol. 25, no. 2, pp. 60–67, 2010.

S. W. Ahn et al., “Long term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders : a retrospective observational study,” Int. J. Bipolar Disord., vol. 5, no. 24, pp. 1–9, 2017.

R. F. Mcknight, M. Adida, K. Budge, S. Stockton, G. M. Goodwin, and J. R. Geddes, “Lithium toxicity profi le : a systematic review and meta-analysis,” Lancet, vol. 379, no. 9817, pp. 721–728, 2012.

G. Ayano, “Bipolar Disorder : Open Access Bipolar Disorders and Valproate : Pharmacokinetics , Pharmacodynamics , Therapeutic Effects and Indications of Valproate : Review of Articles,” Bipolar Disord., vol. 2, no. 2, pp. 1–5, 2016.

Unduhan

Diterbitkan

2024-11-14

Terbitan

Bagian

Articles

Cara Mengutip

Hubungan Terapi Kombinasi Mood Stabilizer dan Antipsikotik dengan Kemampuan Fungsional Pasien Gangguan Afektif Bipolar di Rumah Sakit Jiwa Grhasia Yogyakarta: Relationship between Mood Stabilizer and Antipsychotic Combination Therapy with Functional Ability of Bipolar Affective Disorder Patients at Grhasia Mental Hospital Yogyakarta. (2024). Jurnal Sains Dan Kesehatan, 3(5), 633-638. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/470