Test the Effect of Miana Leaf Ethanol Extract on Ureum and Creatinine Levels in Male White Rats

Authors

  • Joni Tandi Program Studi S1 Farmasi, STIFA Pelita Mas Palu, Indonesia Author
  • Yustin Yustin Program Studi S1 Farmasi, STIFA Pelita Mas Palu, Indonesia Author
  • Rezky Yanuarty Program Studi S1 Farmasi, STIFA Pelita Mas Palu, Indonesia Author
  • Tien Wahyu Handayani Program Studi S1 Farmasi, STIFA Pelita Mas Palu, Indonesia Author

Keywords:

Miana leaves, Streptozotozin, Ureum, Creatinie

Abstract

This study aims to determine the content of secondary metabolites in miana leaf ethanol extract, and to determine the effective dose of miana leaf ethanol extract in reducing urea and creatinine levels in male white rats. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 150 mg/kg BW, dose 200 mg/kg BW, and dose 250 mg/kg. kg body weight. The data obtained will then be tested for normality and homogeneity to find out the data is normally distributed and homogeneous. If the data is normally distributed and homogeneous, then it is continued using One Way Anova statistical analysis at a 95% confidence level and further LSD test is carried out. If the data obtained is not normal and homogeneous, then it is analyzed using non-parametric statistics Kruskal-Wallis test and continued with Mann Whitney further test to determine the difference between all treatments. The results showed that the ethanolic extract of miana leaves contained secondary metabolites of alkaloids, flavonoids, saponins,and tannins; miana leaf ethanol extract has an effect on reducing urea and creatinine; Miana leaf ethanol extract at a dose of 250 mg/kg BW was an effective dose in reducing urea and creatinine with an average decrease of 18.8 mg/dl and 0.64 mg/dl.

References

Syafika Alaydrus et al. (2020) ‘Uji Efek Etanol Daun Benalu Batu Terhadap Kreatinin Ureum Tikus Putih Jantan Diinduksi Streptozotocin’, Scientia?: Jurnal Farmasi dan Kesehatan, 10(1), p. 33. doi: 10.36434/scientia.v10i1.315.

Wulandari Ayu., Syafika Alaydrus., S. (2020) “Uji Efek Ekstrak Etanol Biji Labu Kuning (Cucurbita moschata D) Terhadap kadar Kreatinin & Ureum Tikus Putih Jantan (Rattus norvegicus) Model Hiperkolesterolemia-Diabetes,” Acta Holist Pharm, 2, hal. 1–8.

Aji, N. P. dkk. (2016) “Efek Kombinasi Ekstrak Etanol Herba Sambiloto (Andrographis Paniculata) dan Daun Kelor (Moringa Oleifera) terhadap kadar Ureum dan Kreatinin pada tikus wistar yang diinduksi Streptozotocin,” Jurnal Akademi Farmasi Prayoga, 1(1), hal. 13–18.

Fatma, R. Z. dkk. (2019) “Perbedaan Kadar Ureum Pada Plasma Lithium Heparin Dengan Penggunaan Separator Tube Dan Vacutainer Pada Pasien Post Hemodialisa,” Journal of Chemical Information and Modeling, 53(9), hal. 1689–1699.

Paramita, N. P. A. I. (2019) “Gambaran Kadar Kreatinin Serum Pada Anggota Fitnes Center Di Rai Fitnes Bandung,” Journal of Chemical Information and Modeling, 53(9), hal. 1689–1699.

Wakhidah, A. Z. dkk. (2018) “Etnofarmakologi Tumbuhan Miana (Coleus Scutellariodes (L.) Benth) Pada Masyarakat Halmahera Barat, Maluku Utara,” Pro-Life, 5(2), hal. 567–578. Tersedia pada: http://explorer.natureserve.org.

Palette, T. (2017) “Efek Ekstrak Daun Miana Ungu (Coleus scutellarioides (L) Benth) Terhadap Mycobacterium Tuberculosis Pada Mencit Yang Telah Di Induksi Dengan Mycobacterium Secara Intraperitonium,” Manajemen Asuhan Kebidanan Pada Bayi Dengan Caput Succedaneum Di Rsud Syekh Yusuf Gowa Tahun, 4, hal. 9–15.

Illyyani, S. dkk. (2015) “Pengaruh Pemberian Ekstrak Etanol Tanaman Iler ( Coleus atropurpureus Benth ) Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Putih Jantan yang Diinduksi Aloksan,” 2(1), hal. 19–25.

Podungge, M. R. dkk. (2017) “Isolasi dan Uji Aktivitas Antioksidan Senyawa Flavonoid dari Daun Miana ( Coleus ScutelleroidePodungge, M.R., Salimi, Y.K. & Duengo, S. 2017. Isolasi dan Uji Aktivitas Antioksidan Senyawa Flavonoid dari Daun Miana ( Coleus Scutelleroides Benth.),” Jurnal Entropi, 1(1), hal. 67–74.

Anita, A. dkk. (2019) “Uji Daya Hambat Ekstrak Daun Miana (Coleus Atropurpureus) Terhadap Escherichia coli,” Jurnal Media Analis Kesehatan, 10(1), hal. 72. doi: 10.32382/mak.v10i1.1040.

Joni Tandi, D. N. M. (2019) ‘Pengaruh Ekstrak Etanol Daun Kacang Terhadap Kadar Ureum Kreatinin Tikus Putih Yang Diinduksi Streptozotocin’, Jurnal Farmasi, 16(2). Available at: http://jfarma.org/index.php/farmakologika/article/view/107.

Joni, T. dkk. (2017) “Efek Ekstrak Etanol Daun Gendola Merah (Basella alba L .) terhadap Kadar Kreatinin , Ureum dan Deskripsi Histologis Tubulus Ginjal Tikus Putih Jantan ( Rattus norvegicus ) Diabetes yang Diinduksi Streptozotocin,” 3(2), hal. 93–102. doi: 10.22487/j24428744.2017.v3.i2.8813.

Tandi, J., Roem, Moeh., Yuliet, Y. (2017) “Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol,” Journal Of Tropical Pharmacy And Chemistry, 4(1), hal. 27–34.

Tandi, J. dkk. (2017) “Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol,” Journal Of Tropical Pharmacy And Chemistry, 4(1), hal. 27–34. doi: 10.25026/jtpc.v4i1.129.

Defriana, D., Fridayanti, A. and Rijai, L. (2015) ‘Efek Ekstrak Tanduk Rusa Sambar (Cervus unicolor) Terhadap Kadar Ureum Dan Kreatinin Tikus Putih (Rattus novergicus)’, Jurnal Sains dan Kesehatan, 1(2), pp. 51–55. doi: 10.25026/jsk.v1i2.16.

Wirawan, W. (2018). Uji Ekstrak Etanol Daun Ciplukan Terhadap Gambaran Histopatologi Ginjal Tikus Putih Jantan Diinduksi Streptozotocin, XV(2).

Tandi, J., Wulandari, A., Asrifa, A. (2017) “Efek Ekstrak Etanol Daun Gendola Merah (Basella alba L.) terhadap Kadar Kreatinin, Ureum dan Deskripsi Histologis Tubulus Ginjal Tikus Putih Jantan (Rattus norvegicus) Diabetes yang Diinduksi Streptozotocin,” Galenika Journal of Pharmacy), 3(1), hal. 93–102.

Downloads

Published

2024-11-14

Issue

Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.

Section

Articles

How to Cite

Test the Effect of Miana Leaf Ethanol Extract on Ureum and Creatinine Levels in Male White Rats. (2024). Jurnal Sains Dan Kesehatan, 4(SE-1), 23-30. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/507