Analisis efektivitas berbagai pendekatan formulasi gel topikal mikonazol nitrat pada aktivitas antijamur: Analysis of the effectiveness of various approaches to mikonazol nitrat topical gel formulation on antifungal activity

Venna Sinthary; Sri Wilma; Amirah; Mikailya Malikul Firdaus; Roudhotun Na'imah; Daya Auliya Nur Khasanah; Aulia Utari Fauziah; Dinda Tri Rahayu; Rhabtania Syaira Nurfadilla

doi:10.30872/jsk.v7i2.1118

Authors

Venna Sinthary Author https://orcid.org/0000-0001-7109-4057
Sri Wilma Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Amirah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Mikailya Malikul Firdaus Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Roudhotun Na'imah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Daya Auliya Nur Khasanah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Aulia Utari Fauziah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Dinda Tri Rahayu Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Rhabtania Syaira Nurfadilla Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v7i2.1118

Keywords:

antijamur, Formulasi, gel, miconazole nitrate, tranferosomal

Abstract

Penelitian ini bertujuan untuk meninjau efektivitas berbagai formulasi gel topikal mikonazol nitrat terhadap aktivitas antijamur. Metode yang digunakan berupa tinjauan pustaka dengan menelusuri artikel ilmiah dari Google Scholar, PubMed, MDPI, ResearchGate, dan Elsevier yang diterbitkan dalam sepuluh tahun terakhir tahun 2015 hingga 2025 dengan menggunakan kata kunci gel miconazole nitrate dan formulation of gel miconazole nitrate. Artikel yang dikaji mencakup penelitian eksperimental yang melaporkan formulasi serta hasil uji aktivitas antijamur sediaan gel miconazole nitrat. Hasil menunjukkan bahwa tujuh formulasi memiliki aktivitas antijamur dengan efektivitas yang bervariasi bergantung pada sistem penghantaran dan bahan tambahan yang digunakan. Gel transferosomal yang dikembangkan oleh Qushawy et al merupakan formulasi paling efektif, dengan zona hambat mencapai 55 mm, lebih tinggi dibandingkan krim komersial Daktarin® 2% (50 mm), selanjutnya Hydrogel dengan basis guar gum menunjukkan zona hambat tertinggi kedua sebesar 28 mm, diikuti gel miselar (21 mm) dan gel transtosomal (20,5 mm). Formulasi mikrospons (17 mm), In situ gel (12 mm) dan lipogel (2,6 mm) juga menunjukkan hasil yang baik meskipun lebih rendah.

Author Biography

Venna Sinthary

Department of Pharmacy

References

[1] K. Jadhav, S. Jadhav, D. Sonawane, D. Somvanshi, H. Shah, and P. Patil, “Formulation and Evaluation of Mikonazol nitrat Loaded Novel Nanoparticle Gel for Topical Delivery,” J. Pharm. Res. Int., pp. 292–307, Sep. 2021, doi: 10.9734/jpri/2021/v33i44a32616.

[2] J. Lewis and J. Graybill, “Fungicidal versus Fungistatic: what’s in a word?,” Expert Opin. Pharmacother., vol. 9, pp. 927–935, May 2008, doi: 10.1517/14656566.9.6.927.

[3] O. M. Alwan and I. S. Jaafar, “Development of synergistic antifungal in situ gel of mikonazol nitrat loaded microemulsion as a novel approach to treat vaginal candidiasis,” Sci. Rep., vol. 14, no. 1, Dec. 2024, doi: 10.1038/s41598-024-74021-3.

[4] D. dos Santos Porto, L. Bajerski, M. Donadel Malesuik, and C. Soldateli Paim, “A Review of Characteristics, Properties, Application of Nanocarriers and Analytical Methods of Luliconazole,” Crit. Rev. Anal. Chem., vol. 52, no. 8, pp. 1930–1937, Nov. 2022, doi: 10.1080/10408347.2021.1926219.

[5] A. Ahsan et al., “Formulation and evaluation of mikonazollipogel for enhanced drug permeation,” vol. 37, no. 1, pp. 95–105, 2024, doi: 10.36721/PJPS.2024.37.1.REG.095-105.1.

[6] Z. Asghar, T. Jamshaid, M. Sajid-ur-Rehman, U. Jamshaid, and H. A. Gad, “Novel Transethosomal Gel Containing Mikonazol nitrat; Development, Characterization, and Enhanced Antifungal Activity,” Pharmaceutics, vol. 15, no. 11, Nov. 2023, doi: 10.3390/pharmaceutics15112537.

[7] N. Gulati, N. Tomar, and U. Nagaich, “MikonazolMicrosponges based topical delivery system for diaper dermatitis,” Ars Pharmaceutica, vol. 57, no. 2, pp. 77–87, 2016, doi: 10.4321/S2340-98942016000200006.

[8] G. Hariharaputhraayyanar et al., “FORMULATION, CHARACTERIZATION AND EVALUATION OF TOPICAL GEL CONTAINING MIKONAZOL NITRAT FOR FUNGAL INFECTION,” Int. J. Recent Sci. Res., vol. 16, pp. 126–132, 2025, doi: 10.24327/ijrsr.20251602.023.

[9] M. Qushawy, A. Nasr, M. Abd-Alhaseeb, and S. Swidan, “Design, optimization and characterization of a transfersomal gel using mikonazol nitrat for the treatment of candida skin infections,” Pharmaceutics, vol. 10, no. 1, Mar. 2018, doi: 10.3390/pharmaceutics10010026.

[10] V. Singh, M. Kumar, and K. Pathak, “Development of Mikonazol nitrat loaded micellar gel for improved topical delivery.” [Online]. Available: http://www.tjps.pharm.chula.ac.th