Uji Acak Terkendali (RCT): Perbandingan Efektivitas Nanosuspensi Ekstrak Daun Jarak Cina (Jatropha multifida L.) dengan Terapi Standar pada Acne Vulgaris Derajat Ringan-Sedang

Randomized Controlled Trial (RCT): Comparison of the Effectiveness of Jatropha multifida L. Leaf Extract Nanosuspension with Standard Therapy for Mild-Moderate Acne Vulgaris

Authors

  • Jamili Program Studi Diploma III, Fakultas Farmasi, Akademi Farmasi Bumi Siliwangi, Bandung, Indonesia Author
  • Tubagus Akmal Program Studi Diploma III, Fakultas Farmasi, Akademi Farmasi Bumi Siliwangi, Bandung, Indonesia Author
  • Cszahreyloren Vitamia Program Studi Diploma III, Fakultas Farmasi, Akademi Farmasi Bumi Siliwangi, Bandung, Indonesia Author
  • Irma Rahmawati Program Studi Diploma III, Fakultas Farmasi, Akademi Farmasi Bumi Siliwangi, Bandung, Indonesia Author
  • Susi Afrianti Rahayu Program Studi Diploma III, Fakultas Farmasi, Akademi Farmasi Bumi Siliwangi, Bandung, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v7i2.1025

Keywords:

Jatropha multifida L , nanosuspensi, antibakteri, Propionibacterium acnes

Abstract

Acne vulgaris merupakan penyakit kulit inflamasi kronis yang berhubungan dengan kolonisasi bakteri Propionibacterium acnes. Penggunaan antibiotik jangka panjang dalam terapi jerawat telah meningkatkan risiko resistensi bakteri, sehingga diperlukan alternatif antibakteri yang aman dan efektif. Penelitian ini bertujuan mengevaluasi karakteristik fisik dan aktivitas antibakteri nanosuspensi ekstrak daun Jatropha multifida terhadap Propionibacterium acnes secara in vitro. Ekstrak daun diperoleh melalui metode maserasi menggunakan etanol 96% sebagai pelarut dan diformulasikan menjadi nanosuspensi dengan metode nanopresipitasi menggunakan menggunakan Tween 80 sebagai bahan penstabil. Hasil karakterisasi menunjukkan ukuran partikel rata-rata sebesar 185,2 nanometer, indeks polidispersitas sebesar 0,214, serta potensi zeta -32,7 milivolt yang menunjukkan stabilitas fisik yang baik. Pengujian aktivitas antibakteri pada konsentrasi terendah yang mampu menghambat pertumbuhan bakteri adalah 2,5%, sedangkan efek pembunuhan bakteri terjadi pada konsentrasi 5%. Hasil penelitian ini menunjukkan bahwa nanosuspensi ekstrak daun Jatropha multifida berpotensi dikembangkan sebagai antibakteri alami alternatif dalam terapi jerawat.

 

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Published

2026-05-28

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Vol. 7 No. 2 (2026): J. Sains Kes.

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How to Cite

[1]
Jamili, T. . Akmal, C. . Vitamia, I. . Rahmawati, and S. . Afrianti Rahayu, “Uji Acak Terkendali (RCT): Perbandingan Efektivitas Nanosuspensi Ekstrak Daun Jarak Cina (Jatropha multifida L.) dengan Terapi Standar pada Acne Vulgaris Derajat Ringan-Sedang: Randomized Controlled Trial (RCT): Comparison of the Effectiveness of Jatropha multifida L. Leaf Extract Nanosuspension with Standard Therapy for Mild-Moderate Acne Vulgaris”, J. Sains. Kes, vol. 7, no. 2, pp. 96–103, May 2026, doi: 10.30872/jsk.v7i2.1025.

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