Senyawa Alkaloid Furokuinolin dari Kulit Batang Zanthoxylum acanthopodium DC

Authors

  • Tjitjik Srie Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author https://orcid.org/0000-0003-0894-9803
  • Alfiah Nur Irza Gunawan Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author
  • Ratih Dewi Saputri Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author https://orcid.org/0000-0002-5982-8983
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author https://orcid.org/0000-0002-8252-6692

Keywords:

Zanthoxylum acanthopodium DC., diktammin, skimmianin, antikanker

Abstract

Dua senyawa alkaloid furokuinolin, diktammin (1) dan skimmianin (2) telah berhasil diisolasi dari kulit batang Zanthoxylum acanthopodium DC. Penentuan struktur kedua senyawa alkaloid ditetapkan berdasarkan analisis spektrum UV, IR, MS,1D dan 2D NMR. Uji aktivitasantikanker senyawa 1–2 terhadap sel murine leukemia P-388 memperlihatkan nilai IC 50 10,41 dan 4,85 μg/ml.

References

Asbur, Y., Khairunnisyah, (2018). Pemanfaatan andaliman (Zanthoxylum acanthopodium DC) sebagai tanaman penghasil minyak atsiri, J. Kultivasi, 17(1), 537-542.

Kristanty, R.E., Suriawati, J., (2014). Cytotoxicand antioxidant activity of petroleum extract of andaliman fruits(Zanthoxylum acanthopodium DC). International J. Pharm.Tech. Res. 6(3),1064–1069.

Khasanah, S.N.N., Imaniah, N., Saputri, R.D.,Tjahjandarie, T.S., Tanjung, M., (2018), Kumarin terisoprenilasi dan alkaloid indol dari kulit batang Zanthoxylum ovalifolium Tutcher, J. Kimia Mulawarman, 15(2),76-82.

Marliana, E., Tjahjandarie, T.S., Tanjung, M.,(2016). Aktivitas antioksidan senyawa flavonoid dari Macaranga pearsonii Merr. J. Kimia Mulawarman. 13(2),97-100

Saputri,R.D.,Tanjung, M.,Tjahjandarie, T.S., (2018). Cytotoxicactivity of quinolinone alkaloid sand acylphloroglucinolfrom the leaves of Melicope denhamii. J.Physics: Conference Series,1095(1),012031

Tanjung, M., Saputri,R.D., Tjahjandarie,T.S., (2017). 4-Methoxy-3-(3-methylbut-2-en-1-yl)-7-((3-methylbut-2-en-1-yl)oxy) quinolin-2(1H)-one from Melicope moluccana T .G. Hartley. Molbank. M939. 2,1-5.

Tjahjandarie, T.S., Tanjung, M., (2015). Lead compound antimalaria dan antioksidan senyawa alkaloid, flavonoid, dan kumarin dari Limonia accidisima L. Laporan Akhir Penelitian Unggulan Perguruan Tinggi, UniversitasAirlangga. 1-45.

Tjahjandarie, T.S., Saputri,R.D.,Wahjoedi, R.A., Tanjung, M., (2018). Melimoluccanin, a new isoprenylated quinolinone alkaloid from the leaves of Melicope moluccana T.G.Hartley. J.Physics: Conference Series, 1095(1), 012042

Tanjung, M., Rachmadiarti, F., Saputri, R.D.; Tjahjandarie, T.S., (2018). Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm. Nat. Prod. Res., 32(9), 1062-1067

Saputri,R.D.,Tjahjandarie, T.S., Tanjung, M.,(2019). Alkaloid furokuinolin dan asam sinamat ter-O-geranilasi dari Melicope hookeri T.G. Hartley. J.Sains dan Kesehatan,2(1),1-7.

Saputri,R.D.,Tjahjandarie, T.S., Tanjung, M.,(2018). Alkaloid kuinolin dari Melicope denhamii dan uji aktivitas antikankernya. J.Sains dan Kesehatan,1(9),505-509.

Parhoodeh, P., Rahmani, M., Hashim, N.M., Sukari, M.A., Ee, G.C.L., (2012), Alkaloid constituents of Haplophyllum laeviusculum (Rutacea), Sains Malay., 41(1), 47-52

Downloads

Published

2019-12-31

Issue

Vol. 2 No. 2 (2019): J. Sains Kes.

Section

Articles

How to Cite

[1]
T. Srie Tjahjandarie, A. Nur Irza Gunawan, R. Dewi Saputri, and M. Tanjung, “Senyawa Alkaloid Furokuinolin dari Kulit Batang Zanthoxylum acanthopodium DC”, J. Sains. Kes, vol. 2, no. 2, Dec. 2019, Accessed: Oct. 09, 2025. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/52

Similar Articles

You may also start an advanced similarity search for this article.