Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya

Authors

  • Ratih Saputri Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author
  • Tjitjik Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author

Keywords:

Melicope denhamii, alkaloid kuinolin terisoprenilasi, sel P-388, antikanker

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii.  Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 1–2 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat

References

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Published

2024-11-14

Issue

Vol. 1 No. 9 (2018): J. Sains Kes.

Section

Articles

How to Cite

Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya. (2024). Jurnal Sains Dan Kesehatan, 1(9), 505-509. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/77