Aktivitas Anti-Inflamasi Ekstrak Etanol Daun Mekai (Albertisia papuana Becc.) Pada Kaki Tikus Wistar Jantan Yang Diinduksi Karagenan

Anti-Inflammatory Activity of Mekai Leaves (Albertisia papuana Becc.) Ethanol Extract of Carrageenan-Induced Paw Edema In Male Wistar Rats

Authors

  • Satriani Badawi Fakultas Farmasi Universitas Mulawarman Author
  • Putri Anggreini Author
  • Noviyanti Indjar Gama Author
  • Helmi Helmi Author
  • Nur Rezky Khairun Nisaa Author

DOI:

https://doi.org/10.30872/jsk.v6i2.750

Keywords:

Albertisia papuana, aktivitas antiinflamasi, karegenan

Abstract

Inflamasi merupakan tanda kerusakan jaringan yang dapat disebabkan oleh patogen ataupun trauma. Metabolit sekunder Albertisi papuana terbukti memiliki aktivitas antibakteri, antifungi dan antiplasmodial. Daun ini juga diduga memiliki antioksidan yang mampu berperan sebagai antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui aktivitas antiinflamsi ekstrak etanol A. papuana. Tikus wistar dibagi menjadi 5 kelompok yaitu kelompok N, C, C+SDc, APE125 dan APE500. Telapak kaki kiri tikus diinduksi karagenan 1% sebagi agen induksi inflamasi. Volume udem awal (V0) dan pemberian ekstrak dilakukan 1 jam sebelum induksi karagenan. Perubahan volume udem diukur setiap 1 jam selama 6 jam. Setelah itu hewan didislokasi, kaki dipotong dan ditimbang beratnya. Hasil pengujian ANOVA menunjukkan peningkatan berat kaki pada kelompok kontrol (P<0.018). Persentase inhibisi inflamasi kelompok kontrol C+SDc 46.43%, kelompok APE125 39.33% dan kelompok APE500 20.44%. Senyawa flavonoid dan fenolik diduga berperan dalam penurunan volume udem dan peningkatan persentase inhibisi inflamasi pada hewan uji.

References

[1] S. Sharma, D. Kumar, G. Singh, V. Monga, and B. Kumar, “Recent advancements in the development of heterocyclic anti-inflammatory agents,” Eur. J. Med. Chem., vol. 200, p. 112438, 2020, doi: 10.1016/j.ejmech.2020.112438.

[2] K. Tarı Selçuk, “Epidemiology of Inflammation-Related Diseases,” 2020, pp. 24–44. doi: 10.4018/978-1-7998-3594-3.ch002.

[3] A. Lenz, G. A. Franklin, and W. G. Cheadle, “Systemic inflammation after trauma,” Injury, vol. 38, no. 12, pp. 1336–1345, 2007, doi: 10.1016/j.injury.2007.10.003.

[4] H. P. Yu, I. H. Chaudry, M. A. Choudhry, C. H. Hsing, F. C. Liu, and Z. Xia, “Inflammatory response to traumatic injury: Clinical and animal researches in inflammation,” Mediators Inflamm., vol. 2015, pp. 2–4, 2015, doi: 10.1155/2015/729637.

[5] N. Nurbani, “Eksplorasi dan karakterisasi tumbuhan mekai sebagai penyedap rasa di Kabupaten Bulungan, Provinsi Kalimantan Utara,” vol. 1, no. April, pp. 201–206, 2015, doi: 10.13057/psnmbi/m010206.

[6] Y. B. Sarifati, S. Ismail, and K. Kosala, “Uji Aktivitas Antibakteri Ekstrak Etanol Daun Mekai (Pycnarrhena cauliflora DIELS.) terhadap Staphylococcus aureus,” J. Ilm. Manuntung, vol. 6, no. 2, p. 246, 2020, doi: 10.51352/jim.v6i2.369.

[7] H. Hajrah, N. Indriyanti, M. Priastomo, E. Samsul, and W. C. Prabowo, “The Chemical Profile and Potency of Albertisia papuana Leaves in Suppressing Withdrawal Symptoms of Morphine Addiction in Mice,” Malaysian J. Chem., vol. 23, no. 4, pp. 89–94, 2021, doi: 10.55373/MJCHEM.V23I4.1191.

[8] N. A. B. Incau, M. Almeida, and N. Indriyanti, “Skrinning Aktivitas Antimikroba Ekstrak Etanol Daun Mekai (Albertisia sp.),” Proceeding Mulawarman Pharm. Conf., no. April 2021, pp. 135–138, 2021.

[9] R. Agustina, D. T. Indrawati, and M. A. Masruhin, “Aktivitas Ekstrak Daun Salam (Eugenia Polyantha) Sebagai Antiinflamasi Pada Tikus Putih (Rattus Norvegicus),” J. Trop. Pharm. Chem., pp. 120–123, 2015.

[10] Utami ET, Kuncoro RA, Hutami IR, Sari FT, and Handajani J, “Efek Antiinflamasi Ekstrak Daun Sembukan (Paederia scandens) Pada Tikus Wistar,” Maj. Obat Tradis., vol. 16, no. 2, pp. 95–100, 2011.

[11] F. Hasanah and N. Hidayah, “Uji Aktivitas Antiinflamasi Ekstrak Air Daun Salam (Sygyzium Polyanthum Wight.) terhadap Tikus Wistar Jantan yang Diinduksi Dengan Karagenan 1%,” J. Pharm. Sci., vol. 1, no. 1, pp. 16–22, 2018, doi: 10.36490/journal-jps.com.v1i1.3.

[12] A. K. Gupta et al., “Analgesic and anti-inflammatory properties of gelsolin in acetic acid induced writhing, tail immersion and carrageenan induced paw edema in mice,” PLoS One, vol. 10, no. 8, 2015, doi: 10.1371/journal.pone.0135558.

[13] K. Fitri, T. N. Khairani, K. T. Sianturi, L. Leny, and I. Hafiz, “Anti-inflammatory Activity of Ethanol Extract of Lotus (Nelumbo nucifera G.) Seed Against White Male Rats Using Paw Edema Method,” J. Drug Deliv. Ther., vol. 11, no. 4, pp. 1–4, 2021, doi: 10.22270/jddt.v11i4.4918.

[14] H. M. Maswadeh, M. H. Semreen, and A. R. Naddaf, “Anti-inflammatory activity of Achillea and ruscus topical gel on carrageenan-induced paw edema in rats,” Nat. Drugs, vol. 63, p. 277, 2006, doi: 10.1007/s13596-020-00502-1.

[15] B. Buisseret, O. Guillemot-Legris, G. G. Muccioli, and M. Alhouayek, “Prostaglandin D 2 -glycerol ester decreases carrageenan-induced inflammation and hyperalgesia in mice,” Biochim. Biophys. Acta - Mol. Cell Biol. Lipids, vol. 1864, no. 5, pp. 609–618, 2019, doi: 10.1016/j.bbalip.2019.01.009.

[16] M. Ulubay, K. K. Yurt, A. A. Kaplan, and M. K. Atilla, “The use of diclofenac sodium in urological practice: A structural and neurochemical based review,” J. Chem. Neuroanat., vol. 87, pp. 32–36, 2018, doi: 10.1016/j.jchemneu.2017.02.005.

[17] R. E. Mutha, A. U. Tatiya, and S. J. Surana, “Flavonoids as natural phenolic compounds and their role in therapeutics: an overview,” Futur. J. Pharm. Sci., vol. 7, no. 1, 2021, doi: 10.1186/s43094-020-00161-8.

[18] P. Arulselvan et al., “Role of Antioxidants and Natural Products in Inflammation,” Oxid. Med. Cell. Longev., vol. 2016, 2016, doi: 10.1155/2016/5276130.

[19] Y. Yamamoto and R. B. Gaynor, “Potencial terapéutico de la inhibición de la vía NF-κB en el tratamiento de la inflamación y el cáncer,” J. Clin. Invest., vol. 107, no. 2, pp. 135–142, 2001.

[20] N. Chekalina et al., “Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease,” Indian Heart J., vol. 70, no. 5, pp. 593–597, 2018, doi: 10.1016/j.ihj.2018.04.006.

[21] T. Lawrence, “The nuclear factor NF-kappaB pathway in inflammation.,” Cold Spring Harb. Perspect. Biol., vol. 1, no. 6, pp. 1–10, 2009, doi: 10.1101/cshperspect.a001651.

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Published

2025-07-31

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Vol. 6 No. 2 (2025)

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How to Cite

[1]
S. Badawi, Putri Anggreini, Noviyanti Indjar Gama, Helmi Helmi, and Nur Rezky Khairun Nisaa, “Aktivitas Anti-Inflamasi Ekstrak Etanol Daun Mekai (Albertisia papuana Becc.) Pada Kaki Tikus Wistar Jantan Yang Diinduksi Karagenan: Anti-Inflammatory Activity of Mekai Leaves (Albertisia papuana Becc.) Ethanol Extract of Carrageenan-Induced Paw Edema In Male Wistar Rats”, J. Sains. Kes, vol. 6, no. 2, pp. 54–60, Jul. 2025, doi: 10.30872/jsk.v6i2.750.

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