Efek Penambahan Kolesterol dan Tween 80 terhadap Karakteristik dan Stabilitas Fisik Liposom Hydrolyzed Collagen

The Effect of Adding Cholesterol and Tween 80 on the Physical Characteristics and Stability of Hydrolyzed Collagen Liposomes

Authors

  • Alya Nur Amilia Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia Author
  • Noorma Rosita Department of Pharmaceutical Sciences, Faculty Pharmacy, Universitas Airlangga, Surabaya, East Java-60115, Indonesia Author
  • Helmy Yusuf Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia Author https://orcid.org/0000-0001-5929-4726

DOI:

https://doi.org/10.30872/j.sains.kes.v6i1.310

Keywords:

Karakteristik, hydrolized collagen, liposom, kolestrol, tween 80

Abstract

Hydrolized Collagen (HC) memiliki aktivitas anti-aging yang sangat baik, namum secara topikal memiliki keterbatasan terkait sifat fisika kimia dan permeabilitasnya yang rendah untuk menembus kulit. Dibutuhkan suatu sistem seperti liposom. Dengan penambahan kolesterol dan surfaktan Tween 80 ke dalam formulasi liposom diharapkan akan meningkatkan karakteristik dan stabilitas sistem dalam beberapa perbandingan kombinasi formula Soy phospatidylcholine:  kolesterol: Tween 80 yaitu (F1= 4: 2: 1), (F2= 4: 1: 1), dan (F3= 4: 1: 2). Hasil uji karakteristik menunjukkan formula F3 memiliki karakteristik terbaik dengan nilai ukuran partikel, PDI, zeta potensial, dan %EE secara berturut-turut 63,26nm ± 0,73; 0,182 ± 0,011; 2,5mV ± 0,1; dan 85,54% ± 0,20. Hasil uji stabilitas real-time menunjukkan hasil analisis statistik menggunakan Paired T-test diperoleh p-value ketiga formula yaitu Sig (2- tailed) < 0,05, yang berarti terdapat perbedaan yang signifikan dan formula F2 yang memiliki selisih penurunan ukuran partikel dan %EE terkecil. Sehingga, dapat dilihat bahwa F2 merupakan formula yang memiliki karakteristik dan stabilitas paling baik dibandingkan dengan F1 dan F3.

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Published

2024-11-15

Issue

Vol. 6 No. 1 (2024): J. Sains Kes.

Section

Articles

How to Cite

Efek Penambahan Kolesterol dan Tween 80 terhadap Karakteristik dan Stabilitas Fisik Liposom Hydrolyzed Collagen: The Effect of Adding Cholesterol and Tween 80 on the Physical Characteristics and Stability of Hydrolyzed Collagen Liposomes. (2024). Jurnal Sains Dan Kesehatan, 6(1), 164-171. https://doi.org/10.30872/j.sains.kes.v6i1.310

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