Efek Samping Hipoglikemi yang Dialami oleh Pasien Geriatri yang Berisiko Sindrom Metabolik

Side Effects of Hypoglycemic Experienced by Geriatric Patients Who are at Risk of Metabolic Syndrome

Authors

  • Ditya Ayu Natalia Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta 55164, Indonesia Author
  • Sugiyarto Fakultas Sains dan Teknologi Terapan, Universitas Ahmad Dahlan, Yogyakarta 55191, Indonesia Author
  • Endang Darmawan Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta 55164, Indonesia Author

Keywords:

Sindrom metabolik, Hipoglikemi, Rumah sakit, Yogyakarta

Abstract

Sindrom metabolik adalah kumpulan gejala kelainan metabolik tubuh yang dapat berhubungan dengan berbagai macam penyakit. Tujuan penelitian untuk melihat adanya hubungan karakteristik dari responden terhadap kondisi klinis (parameter tekanan darah, glukosa darah, kolesterol dan trigliserida) dan melihat obat yang sering digunakan. Penelitian ini merupakan studi retrospektif dari 3 rumah sakit di Yogyakarta. Jumlah responden penelitian yaitu 101 pasien geriatri yang berisiko sindrom metabolik dan mengalami efek samping hipoglikemi. Data dikumpulkan menggunakan data rekam medik. Analisis data karakteristik responden dan golongan obat dilakukan secara deskriptif dan chi-square. Hasil penelitian mengindikasikan bahwa mayoritas pasien geriatri yang berisiko mengalami sindrom metabolik adalah perempuan (52,38%) dengan indeks massa tubuh normal (71,43%). Riwayat penyakit yang lebih banyak di alami oleh pasien geriatri yang berisiko mengalami sindrom metabolik adalah diabetes mellitus dan hipertensi (60,95%) dan pasien tidak mengalami komplikasi (67,62%). Riwayat penyakit berkorelasi dengan keadaan klinis pasien khususnya kadar kolesterol dan trigliserida (p<0,05). Selain itu, komplikasi berkorelasi juga dengan nilai tekanan darah (p<0,05). Golongan obat yang paling sering digunakan pasien geriatri yang berisiko sindrom metabolik adalah antihipertensi angiotensin receptor blocker (76,19%), antidiabetes insulin (50,48%) dan antidislipidemia statin (41,90%). 

References

K. G. M. M. Alberti and P. Z. Zimmet, “Definition , Diagnosis and Classification of Diabetes Mellitus and its Complications Part 1?: Diagnosis and Classification of Diabetes Mellitus Provisional Report of a WHO Consultation,” pp. 539–553, 1998.

L. Kazlauskiene, J. Butnoriene, and A. Norkus, “Metabolic syndrome related to cardiovascular events in a 10-year prospective study,” Diabetol. Metab. Syndr., vol. 7, no. 1, pp. 1–7, 2015, doi: 10.1186/s13098-015-0096-2.

Y. U. Kang et al., “Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population?: Results from the Korean National Health Screening,” vol. 9, no. 5, 2014, doi: 10.1371/journal.pone.0093795.

F. E. Li et al., “Sex-based differences in and risk factors for metabolic syndrome in adults aged 40 years and above in Northeast China: Results from the cross-sectional China national stroke screening survey,” BMJ Open, vol. 11, no. 3, pp. 1–10, 2021, doi: 10.1136/bmjopen-2020-038671.

Siti Nur Kholifah, Modul Bahan Ajar Cetak Keperawatan “Keperawatan Gerontik,” Satu. Jaka: Pusat Pendidikan Sumber Daya Manusia Kesehatan, 2016.

M. A. N. Saad, G. P. Cardoso, W. de A. Martins, L. G. C. Velarde, and R. A. da Cruz Filho, “Prevalence of Metabolic Syndrome in Elderly and Agreement among Four Diagnostic Criteri,” Arq. Bras. Cardiol., vol. 102, no. 3, pp. 263–269, 2014, doi: 10.5935/abc.20140013.

C. Wang, “On the Application of Clustering and Classification Techniques to Analyze Metabolic Syndrome Severity Distribution Area and Critical Factors,” 2019.

F. Fenty, W. A, V. DM, and H. P, “METABOLIC SYNDROME AMONG ADULTS IN RURAL AREAS (Sindrom Metabolik pada Dewasa di Daerah Pedesaan),” Indones. J. Clin. Pathol. Med. Lab., vol. 22, no. 3, p. 254, 2018, doi: 10.24293/ijcpml.v22i3.1241.

K. Suastika et al., “Relationship between age and metabolic disorders in the population of Bali,” J. Clin. Gerontol. Geriatr., vol. 2, no. 2, pp. 47–52, 2011, doi: 10.1016/j.jcgg.2011.03.001.

Y. Yi and J. An, “Sex differences in risk factors for metabolic syndrome in the Korean population,” Int. J. Environ. Res. Public Health, vol. 17, no. 24, pp. 1–14, 2020, doi: 10.3390/ijerph17249513.

A. Akrom, E. Darmawan, and N. Maulida, “Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center,” Pharmaciana, vol. 7, no. 2, p. 205, 2017, doi: 10.12928/pharmaciana.v7i2.6717.

I. D. Federation, IDF DIABETES ATLAS. Sixth Edition, Belgium: I., vol. 76, no. 7. Brussels, 2014.

L. de O. Comini et al., “Individual and combined components of metabolic syndrome with chronic kidney disease in individuals with hypertension and/or diabetes mellitus accompanied by primary health care,” Diabetes, Metab. Syndr. Obes. Targets Ther., vol. 13, pp. 71–80, 2020, doi: 10.2147/DMSO.S223929.

M. Sihombing and D. H. Tjandrarini, “Faktor Risiko Sindrom Metabolik Pada Orang Dewasa Di Kota Bogor,” Penelit. Gizi dan Makanan (The J. Nutr. Food Res., vol. 38, no. 1, pp. 21–30, 2015, doi: 10.22435/pgm.v38i1.4418.21-30.

F. Yuliani, F. Oenzil, and D. Iryani, “Artikel Penelitian Hubungan Berbagai Faktor Risiko Terhadap Kejadian Penyakit Jantung Koroner Pada Penderita Diabetes Melitus Tipe 2,” vol. 3, no. 1, pp. 37–40, 2014.

IDF, “The IDF consensus worldwide definition of the metabolic syndrome,” 2006.

D. Oktianti, F. N. Dewi, and M. Pujiawati, “Evaluasi penggunaan obat antihipertensi pada pasien diabetes mellitus di RSI Sultan Agung Semarang 2016,” J. Manaj. dan Pelayanan Farm., vol. 7, no. 4, pp. 197–203, 2017.

P. A. James et al., “2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8),” JAMA - J. Am. Med. Assoc., vol. 311, no. 5, pp. 507–520, 2014, doi: 10.1001/jama.2013.284427.

R. J. Ligthelm, M. Kaiser, and J. Vora, “Insulin Use in Elderly Adults?: Risk of Hypoglycemia and Strategies for Care,” 2012, doi: 10.1111/j.1532-5415.2012.04055.x.

PERKENI, Pedoman Pengelolaan Dislipidemi di Indonesia 2019, Pertama. Jakarta: PB Perkeni, 2019.

Downloads

Published

2024-11-14

Issue

Vol. 4 No. 4 (2022): J. Sains Kes.

Section

Articles

How to Cite

Efek Samping Hipoglikemi yang Dialami oleh Pasien Geriatri yang Berisiko Sindrom Metabolik: Side Effects of Hypoglycemic Experienced by Geriatric Patients Who are at Risk of Metabolic Syndrome. (2024). Jurnal Sains Dan Kesehatan, 4(4), 437–443. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/471