Formulasi dan Uji Efektivitas Shampo Antiketombe Minyak Atsiri Seledri (Apium graveolens) terhadap Jamur Candida albicans

Formulation and Effectiveness Test of Anti-dandruff Shampoo Essential Oil of Celery (Apium graveolens) against Candida albicans Fungus

Authors

  • Asti Vebriyanti Asjur Program Studi Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Megarezky Makassar Author
  • Syaifullah Saputro Program Studi Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Megarezky Makassar Author
  • Tamzil Azizi Musdar Program Studi Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Megarezky Makassar Author
  • Mifta Khaerati Ikhsan Program Studi Sarjana Farmasi Fakultas Farmasi, Universitas Megarezky Makassar Author

Keywords:

Celery Essential Oil, Anti-Dandruff Shampoo, Candida albicans

Abstract

Celery plants contain limonene which belongs to the terpen group which has the potential as antifungal. This study aims to determinethe formulation of celer essential oil anti-dandruff gel shampoo that meets the physical quality requirements with a concentration 0f 1%, 5%, 10%, and to test the effectiveness of celery essential oil anti- dandruff gel shampoo against the fungus Candida albicans that causes dandruff. The research method was carried out experimentally by making an anti-dandruff gel shampoo formula containing celery (Apium graveolens) essential oil and testing its effectiveness against the fungus Candida albicans that causes dandruff using the well method. This study tested the antifungal effectiveness of essential oil anti-dandruff gel shampoo from formula 0 without celery essential oil (blank) as a negative control, formula 1 with 1% celery essential oil concentration, formula 2 with 5% celery essential oil concentration, formula 3 with 10% celery essential oil concentration, and dandruff shampoo containing 2% ketoconazole as a positive control. The result showed that 1. Celery essential oil can be formulated into anti-dandruff gel shampoo preparations that meet the physical quality requirement. 2. The antifungal effect of celery essential oil anti-dandruff gel shampoo on Candida albicans fungus is very strong with an average inhibitor zone diameter of 20,36 mm in formula 1 21,40 mm in formula 2, 21,60 mm in formula 3. There were differences in the inhibitor vale of each concentration of celery essential oil gel shampoo (p<0,05). Concentration of 5% has provided an optimal effect in inhibiting the growth of the fungus Candida albicans.

References

Malonda, T. C., Yamlean, P. V. Y., & Citraningtyas, G. (2017). Formulasi Sediaan Sampo Antiketombe Ekstrak Daun Pacar Air (Impatiens balsamina L.) Dan Uji Aktivitasnya Terhadap Jamur Candida albicans ATCC 10231 Secara In Vitro. Pharmacon Jurnal Ilmiah Farmasi-UNSRAT (Vol. 6).

Panjaitan, B. M. A. (2021). Tingkat Pengetahuan Mahasiswa Fakultas Hukum Universitas Sumatera Utara Terhadap Ketombe. Skripsi. Universitas Sumatera Utara.

Anam, Bahrul & Putri, Mezayu, A. (2017). Inovasi Pembuatan Shampo Dari Ekstrak Seledri Dengan Metode Ultrasonic Extraction-Microwave Distillation (USE-MD). Tugas Akhir. Institut Tehnologi Sepuluh November.

Sari, K. A., Duma, I., & Irianto, K. (2021). Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Sampo Minyak Atsiri Biji Pala (Myristica fragrans). Jurnal JamuKusuma, 1(1), 27–35.

Nurhaen, N., Winarsii, D., & Ridhay, A. (2016). Isolasi dan Identifikasi Komponen Kimia Minyak Atsiri dari Daun, Batang dan Bunga Tumbuhan Salembangu (Melissa sp.). Natural Science: Journal of Science and Technology, 5 (2), 149–157. https://doi.org/10.22487/25411969.2016.v5.i2. 6702.

Utami, C. A. (2020). Formulasi Spraygel Minyak Atsiri Daun Seledri (Apium Graveolens L.) Dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus ATCC 25923. Skripsi. Universitas Islam Indonesia Yogyakarta.

Prabandari, R. (2017). Profil Kromatografi Lapis Tipis Minyak Atsiri Sereh. Journal of Al-Nahrain University Science, 10(2), 52–63.

Suardhika, I. M. (2018). Perbandingan Pengaruh Lama Pengeringan Terhadap Rendemen Minyak Atsiri Kulit Jeruk Manis (Citrus sinensis) dengan Destilasi Uap dan Identifikasi Linalool dengan KLT-Spektrofotodensitometri. Jurnal Farmasi Udayana, 7(2), 77. https://doi.org/10.24843/jfu.2018.v07.i02.p06

Tarigan, R. Y. S. (2021). Formulasi Gel Sampo Antiketombe Dari Minyak Atsiri Lemon (Citrus limon Burm) Dan Aktivitasnya Terhadap Jamur Penyebab Ketombe (Pityrosporum ovale). Skripsi. Universitas Sumatera Utara.

Zatalini, D. F. (2017). Formulasi dan Aktivitas Gel HPMC-Kitosan Terhadap Proses Penyembuhan Luka Bakar Derajat IIA pada Tikus Putih (Rattus norvegicus) Galur Wistar. Skripsi,. Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Etika, A. (2019). Formulasi Dan Uji Aktivitas Sediaan sampo Antiketombe perasan jeruk Purut (Citrus hystrix DC) Terhadap Pertumbuhan Jamur Candida albicans Secara In Vitro. Karya Tulis Ilmiah. Insitut Kesehatan Helvetia Medan.

Sitompul, Y. R. (2017). Identifikasi Bobot Jenis, Indeks Bias Dan Kelarutan Dalam Etanol Dari Minyak Cengkeh, Minyak Sereh Dan Minyak Pala. Skripsi. Universitas Sumatera Utara.

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Published

2022-10-31

Issue

Vol. 4 No. 5 (2022): J. Sains Kes.

Section

Articles

How to Cite

Formulasi dan Uji Efektivitas Shampo Antiketombe Minyak Atsiri Seledri (Apium graveolens) terhadap Jamur Candida albicans: Formulation and Effectiveness Test of Anti-dandruff Shampoo Essential Oil of Celery (Apium graveolens) against Candida albicans Fungus. (2022). Jurnal Sains Dan Kesehatan, 4(5), 481–487. https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/542