Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya

Authors

  • Ratih Saputri Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author
  • Tjitjik Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia Author

Keywords:

Melicope denhamii, alkaloid kuinolin terisoprenilasi, sel P-388, antikanker

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii.  Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 1–2 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat

References

[1]. Heyne, K., 1987. Tumbuhan Berguna Indonesia, Jilid II, Badan Penelitian dan Pengembangan Kehutanan, Departemen Kesehatan Republik Indonesia, Jakarta.

[2]. Li, S-G., Tian, H-Y,. Ye, W-C,. Jiang, R-W. 2011. Benzopyrans and furoquinoline alkaloids from Melicope ptelefolia. Biochem. Sys. Ecol.39: 64-67.

[3]. Kamperdick, C., Van, N. H.; Sung, T. V., Adam, G. 1999. Bisquinolinone alkaloids from Melicope ptelefolia, Phytochem. 50: 177-181.

[4]. Kassim, N.K., Rahmani, M., Ismail, A., Sukari, M.A., Ee, G.C.L., Nasir, N.M., Awang, K., 2013. Antioxsidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae). Food Chem. 139: 87-92.

[5]. Marliana, E., Tjahjandarie, T.S., Tanjung, M., 2016. Aktivitas antioksidan senyawa flavonoid dari Macaranga pearsonii Merr. J. Kimia Mulawarman. 13(2): 97-100.

[6]. Munoz, M.A., Torres, R., Cassels, B.K. 1982, Auraptene and flindersine from Zanthoxylum coco, J. Nat. Prod. 45(3): 367-369.

[7]. Simonsen, H.T., Adsersen, A,. Bremner, P,. Heinrich, M., Smitt, U.W., Jaroszewski, J.W. 2004. Antifungal constituents of Melicope borbonica. Phytoter. Res. 18: 542-545.

[8]. Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., 2017a. 4-Methoxy-3-(3-methylbut-2-en-1-yl)-7-((3-methylbut-2-en-1-yl)oxy) quinolin-2(1H)-one from Melicope moluccana T.G. Hartley. Molbank. M939. 2: 1-5.

[9]. Tanjung, M., Rachmadiarti, F., Prameswari, A., Agyani, V.U.W., Saputri, R.D., Tjahjandarie, T.S., Syah, Y.M. 2017b. Airlanggins A-B, two new isoprenylated benzofuran-3-ones from the stem bark of Calophyllum soulattri. Nat. Prod. Res. 1-6, http://dx.doi.org/10.1080/14786419.2017.1380027

[10]. Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., 2016. Antimalarial and antioxidant of isoprenylated coumarins from the stem bark of Mesua borneensis L.. J Biol Active Prod from Nature. 6: 95-100.

[11]. Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., 2014. Antioxidant activity of two isomeric benzoxepin derivatives from the stem bark of Bauhinia aculeata L. J. Chem. Pharm. Res. 6: 705-708.

[12]. Tanjung, M., Tjahjandarie, T.S., Sentosa, M.H., 2013. Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata. Asian Pacific J. Tropical Disease. 3(5): 401-404.

[13]. Tjahjandarie, T.S., Tanjung, M., 2015. Lead compound antimalaria dan antioksidan senyawa alkaloid, flavonoid, dan kumarin dari Limonia accidisima L.. Laporan Akhir Penelitian Unggulan Perguruan Tinggi, Universitas Airlangga. 1-45.

[14]. Tjahjandarie, T.S.; Saputri, R.D.; Tanjung, M. 2017. 5,9,11-Trihydroxy-2,2-dimethyl-3-(2-methylbut-3-en-2-yl)pyrano[2,3-a] xanthen-12(2H)-one from the stem bark of Calophyllum tetrapterum Miq. Molbank. M936. 1: 1-5.

Downloads

Published

2024-11-14

Issue

Vol. 1 No. 9 (2018): J. Sains Kes.

Section

Articles

How to Cite

[1]
R. Saputri, T. Tjahjandarie, and M. Tanjung, “Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya”, J. Sains. Kes, vol. 1, no. 9, pp. 505–509, Nov. 2024, Accessed: Dec. 17, 2025. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/77

Similar Articles

11-20 of 103

You may also start an advanced similarity search for this article.