Polimorfisme CYP2R1 dan CYP27B1 serta Status Vitamin D terhadap Respons Imun: Tinjauan Scoping
DOI:
https://doi.org/10.30872/jsk.v6i1.981Keywords:
CYP2R1, CYP27B1, 25(OH)D3, respon imun, vitamin DAbstract
Objective: This scoping review aimed to map existing evidence on the association between CYP2R1 and CYP27B1 polymorphisms, vitamin D status, and immune-related outcomes in human studies.
Methods: A scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines using PubMed, ScienceDirect, and Wiley Online Library for studies published between 2013 and 2023.
Results: Eight studies met the inclusion criteria, including randomised controlled trials, cohort studies, and case–control studies. Polymorphisms in CYP2R1 consistently showed significant associations with circulating 25(OH)D levels and response to vitamin D supplementation, whereas CYP27B1 variants demonstrated heterogeneous effects depending on population characteristics and clinical context.
Conclusion: Genetic variability in CYP2R1 and CYP27B1 influences vitamin D status and may modulate immune-related outcomes. However, evidence directly linking these polymorphisms to immune function remains limited, highlighting the need for standardized clinical trials.
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