Analisis efektivitas berbagai pendekatan formulasi gel topikal mikonazol nitrat pada aktivitas antijamur

Analysis of the effectiveness of various approaches to mikonazol nitrat topical gel formulation on antifungal activity

Authors

  • Venna Sinthary Author https://orcid.org/0000-0001-7109-4057
  • Sri Wilma Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Amirah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Mikailya Malikul Firdaus Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Roudhotun Na'imah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Daya Auliya Nur Khasanah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Aulia Utari Fauziah Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Dinda Tri Rahayu Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Rhabtania Syaira Nurfadilla Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v7i2.1118

Keywords:

antijamur, Formulasi, gel, miconazole nitrate, tranferosomal

Abstract

Penelitian ini bertujuan untuk meninjau efektivitas berbagai formulasi gel topikal mikonazol nitrat terhadap aktivitas antijamur. Metode yang digunakan berupa tinjauan pustaka dengan menelusuri artikel ilmiah dari Google Scholar, PubMed, MDPI, ResearchGate, dan Elsevier yang diterbitkan dalam sepuluh tahun terakhir tahun 2015 hingga 2025 dengan menggunakan kata kunci gel miconazole nitrate dan formulation of gel miconazole nitrate. Artikel yang dikaji mencakup penelitian eksperimental yang melaporkan formulasi serta hasil uji aktivitas antijamur sediaan gel miconazole nitrat. Hasil menunjukkan bahwa tujuh formulasi memiliki aktivitas antijamur dengan efektivitas yang bervariasi bergantung pada sistem penghantaran dan bahan tambahan yang digunakan.  Gel transferosomal yang dikembangkan oleh Qushawy et al merupakan formulasi paling efektif, dengan zona hambat mencapai 55 mm, lebih tinggi dibandingkan krim komersial Daktarin® 2% (50 mm), selanjutnya Hydrogel dengan basis guar gum menunjukkan zona hambat tertinggi kedua sebesar 28 mm, diikuti gel miselar (21 mm) dan gel transtosomal (20,5 mm). Formulasi mikrospons (17 mm), In situ gel (12 mm) dan lipogel (2,6 mm) juga menunjukkan hasil yang baik meskipun lebih rendah.

Author Biography

  • Venna Sinthary

    Department of Pharmacy

References

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Published

2026-05-28

Issue

Vol. 7 No. 2 (2026): J. Sains Kes.

Section

Review

License

Copyright (c) 2026 Jurnal Sains dan Kesehatan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


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How to Cite

[1]
V. Sinthary, “Analisis efektivitas berbagai pendekatan formulasi gel topikal mikonazol nitrat pada aktivitas antijamur: Analysis of the effectiveness of various approaches to mikonazol nitrat topical gel formulation on antifungal activity”, J. Sains. Kes, vol. 7, no. 2, pp. 276–285, May 2026, doi: 10.30872/jsk.v7i2.1118.

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