Studi In Silico Senyawa Bioaktif Buah Merah Papua (Pandanus conoideus Lam.) sebagai Kandidat Antioksidan dan Anti-Photoaging untuk Pengembangan Skincare

In Silico Study of Bioactive Compounds from Papuan Red Fruit (Pandanus conoideus Lam.) as Antioxidant and Anti-Photoaging Candidates for Skincare Development

Authors

  • Dalifa Ramadhani Program Studi Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Harra Ismi Farah Program Studi Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Hanggara Arifian Ramadhani Program Studi Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v7i2.1125

Keywords:

Pandanus conoideus, Buah merah, molecular docking, ADMET, Skincare

Abstract

Buah merah Papua (Pandanus conoideus Lam.) merupakan tanaman lokal Papua yang mengandung senyawa bioaktif lipofilik, seperti karotenoid, tokoferol, dan asam lemak tak jenuh, yang berpotensi sebagai antioksidan alami. Penelitian ini bertujuan mengevaluasi potensi senyawa bioaktif buah merah sebagai kandidat antioksidan dan anti-photoaging melalui molecular docking terhadap Keap1 dan MMP-1, serta prediksi drug-likeness dan ADMET. Simulasi docking dilakukan menggunakan AutoDock4, visualisasi interaksi menggunakan BIOVIA Discovery Studio Visualizer, dan prediksi ADMET menggunakan ADMETlab, pkCSM, serta ProTox-II. Senyawa uji meliputi β-carotene, α-carotene, β-cryptoxanthin, α-cryptoxanthin, α-tocopherol, γ-tocopherol, oleic acid, linoleic acid, dan α-linolenic acid. Hasil validasi menunjukkan bahwa protokol docking terhadap Keap1 dan MMP-1 memenuhi kriteria RMSD ≤2 Å. α-Tocopherol menunjukkan afinitas terbaik terhadap Keap1 dengan binding affinity -7,94 kcal/mol, mendekati Trolox sebagai pembanding (-8,12 kcal/mol). γ-Tocopherol menunjukkan afinitas terbaik terhadap MMP-1 dengan binding affinity -10,95 kcal/mol. Integrasi hasil docking dan ADMET menunjukkan bahwa α-tocopherol memiliki profil paling prospektif sebagai kandidat utama. Studi ini mendukung potensi tokoferol buah merah sebagai kandidat bahan aktif skincare berbasis antioksidan dan anti-photoaging.

 

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Published

2026-05-28

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Vol. 7 No. 2 (2026): J. Sains Kes.

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How to Cite

[1]
D. Ramadhani, Harra Ismi Farah, and H. A. . Ramadhani, “Studi In Silico Senyawa Bioaktif Buah Merah Papua (Pandanus conoideus Lam.) sebagai Kandidat Antioksidan dan Anti-Photoaging untuk Pengembangan Skincare: In Silico Study of Bioactive Compounds from Papuan Red Fruit (Pandanus conoideus Lam.) as Antioxidant and Anti-Photoaging Candidates for Skincare Development”, J. Sains. Kes, vol. 7, no. 2, pp. 286–308, May 2026, doi: 10.30872/jsk.v7i2.1125.

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