Polimorfisme CYP2R1 dan CYP27B1 serta Status Vitamin D terhadap Respons Imun: Tinjauan Scoping

Authors

  • Margareta Amelia N rogram Studi Magister Biomedik, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia Author
  • Isadora Gracia Departemen Ilmu Penyakit Gigi dan Mulut, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia Departemen Ilmu Penyakit Gigi dan Mulut, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia Author
  • Linawati Hananta Departemen Farmakologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia , Atma Jaya Research & Teaching Hospital, Jakarta, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v6i1.981

Keywords:

CYP2R1, CYP27B1, 25(OH)D3, respon imun, vitamin D

Abstract

Vitamin D plays a key role in immune regulation, and genetic polymorphisms in vitamin D–metabolising enzymes may influence circulating 25-hydroxyvitamin D [25(OH)D] levels and immune-related outcomes.

Objective: This scoping review aimed to map existing evidence on the association between CYP2R1 and CYP27B1 polymorphisms, vitamin D status, and immune-related outcomes in human studies.

Methods: A scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines using PubMed, ScienceDirect, and Wiley Online Library for studies published between 2013 and 2023.

Results: Eight studies met the inclusion criteria, including randomised controlled trials, cohort studies, and case–control studies. Polymorphisms in CYP2R1 consistently showed significant associations with circulating 25(OH)D levels and response to vitamin D supplementation, whereas CYP27B1 variants demonstrated heterogeneous effects depending on population characteristics and clinical context.

Conclusion: Genetic variability in CYP2R1 and CYP27B1 influences vitamin D status and may modulate immune-related outcomes. However, evidence directly linking these polymorphisms to immune function remains limited, highlighting the need for standardized clinical trials.

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Published

2025-05-31

Issue

Vol. 6 No. 1 (2025): J. Sains Kes.

Section

Review

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How to Cite

[1]
Margareta Amelia N, I. G. Departemen Ilmu Penyakit Gigi dan Mulut, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia, and Linawati Hananta, “Polimorfisme CYP2R1 dan CYP27B1 serta Status Vitamin D terhadap Respons Imun: Tinjauan Scoping”, J. Sains. Kes, vol. 6, no. 1, pp. 108–119, May 2025, doi: 10.30872/jsk.v6i1.981.

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