Pendekatan Design of Experiments (DoE) dalam Optimasi Nanoemulsi Mangostin sebagai Sistem Penghantaran Obat

Design of Experiments (DoE) Approach for Optimizing Mangostin Nanoemulsions as Drug Delivery Systems

Authors

  • Fauzan Afandi Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran Author
  • Ferdy Firmansyah Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru, Riau, Indonesia Author
  • Dalifa Ramadhan Faculty of Pharmacy, Universitas Mulawarman, Samarinda Author
  • M. Wahyu Ariawan Faculty of Pharmacy, Universitas Mulawarman, Samarinda Author https://orcid.org/0000-0003-4666-6601
  • Debi Dinha Oktora Faculty of Pharmacy, Universitas Mulawarman, Samarinda Author
  • Muh. Deni Kurniawan Faculty of Pharmacy, Universitas Mulawarman, Samarinda Author

DOI:

https://doi.org/10.30872/jsk.v7i2.1062

Keywords:

Design of Experiments (DoE), Mangostin, Nanoemulsion, Optimization, Drug Delivery System

Abstract

Mangostin merupakan senyawa aktif utama dari kulit manggis (Garcinia mangostana L.) yang memiliki potensi farmakologis luas. Namun, pemanfaatannya masih dibatasi oleh kelarutan air yang rendah dan bioavailabilitas yang buruk. Pengembangan sistem penghantaran berbasis nanoemulsi menjadi salah satu strategi untuk mengatasi kendala tersebut. Kompleksitas formulasi menuntut pendekatan optimasi yang efisien, sehingga Design of Experiments (DoE) lebih unggul dibandingkan metode trial-and-error konvensional. Penelitian ini bertujuan meninjau secara sistematis penerapan strategi DoE dalam optimasi formulasi penghantaran mangostin, khususnya nanoemulsi, SNEDDS, dan nanoemulgel, untuk memperoleh karakteristik fisikokimia dan stabilitas yang optimal. Penelusuran literatur dilakukan pada database terakreditasi dengan fokus pada studi yang menggunakan rancangan DoE. Hasil tinjauan menunjukkan bahwa Simplex Lattice Design dan Box-Behnken Design merupakan metode yang paling banyak digunakan. Formula optimum umumnya memanfaatkan Virgin Coconut Oil atau minyak kelapa sawit sebagai fase minyak, serta kombinasi Tween 80 dengan PEG 400 atau Span 80 sebagai surfaktan dan ko-surfaktan. Faktor kritis yang paling memengaruhi respons meliputi konsentrasi minyak, rasio surfaktan campuran, dan waktu sonikasi. Optimasi berbasis DoE terbukti menghasilkan sistem dengan ukuran droplet nanometrik, PDI rendah, efisiensi penjeratan tinggi, dan stabilitas fisik yang baik.

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2026-05-29

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F. . Afandi, F. Firmansyah, D. . Ramadhan, M. W. . Ariawan, D. D. . Oktora, and M. D. Kurniawan, “Pendekatan Design of Experiments (DoE) dalam Optimasi Nanoemulsi Mangostin sebagai Sistem Penghantaran Obat: Design of Experiments (DoE) Approach for Optimizing Mangostin Nanoemulsions as Drug Delivery Systems”, J. Sains. Kes, vol. 7, no. 2, pp. 173–196, May 2026, doi: 10.30872/jsk.v7i2.1062.

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