Pengaruh Suplementasi Vitamin D Terhadap Kualitas Hidup Dan Reaksi Obat Yang Merugikan (Adverse Drug Reactions) Pada Pasien Hiv/Aids: Studi Pra Dan Pasca Intervensi
The Effect of Vitamin D Supplementation on Quality of Life and Adverse Drug Reactions in Patients with HIV/AIDS: A Pre- and Post-Intervention Study
DOI:
https://doi.org/10.30872/Keywords:
HIV, kualitas hidup, vitamin D, terapi antiretroviral , adverse drug reactionsAbstract
Tujuan: Penelitian ini bertujuan menganalisis pengaruh suplementasi vitamin D terhadap kualitas hidup dan kejadian ADR pada pasien HIV/AIDS yang menjalani terapi ARV.
Metode: Penelitian kuantitatif dengan desain pra-eksperimental one group pretest–posttest dilakukan di Puskesmas Rapak Mahang, Kabupaten Kutai Kartanegara. Sebanyak 32 pasien HIV diikutsertakan. Kualitas hidup diukur menggunakan WHOQOL-HIV BREF sebelum dan sesudah suplementasi vitamin D selama delapan minggu. Kejadian ADR dinilai melalui pemantauan terstruktur. Analisis statistik menggunakan uji Wilcoxon signed-rank dan uji McNemar.
Hasil: Seluruh responden berada dalam kondisi imunologis stabil (CD4 >500 sel/µL). Setelah intervensi, terjadi peningkatan bermakna pada domain fisik, psikologis, dan kemandirian serta kualitas hidup global (p < 0,001), disertai penurunan signifikan ADR gastrointestinal dan neurologi/psikologis (p ≤ 0,001).
Kesimpulan: Suplementasi vitamin D berasosiasi dengan perbaikan kualitas hidup dan penurunan ADR tertentu pada pasien HIV yang menjalani terapi ARV, serta berpotensi sebagai terapi adjuvan.
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