Pengaruh Minyak Biji Jinten Hitam (Nigella sativa L) terhadap Kadar Interleukin-4

Authors

  • Tantri Rachmayani Universitas Ahmad Dahlan Yogyakarta Author
  • Akrom Akrom Universitas Ahmad Dahlan, Jl. Prof.DR. Soepomo Sh, Warungboto Yogyakarta, 55164, Indonesia Author
  • Titiek Hidayati Universitas Muhammadiyah Yogyakarta, Jl. Brawijaya, Geblagan, Tamantirto, Kasihan Bantul Yogyakarta 5518, Indonesia Author

Keywords:

Minyak Biji Jinten Hitam, Interleukin-4, Perokok Aktif

Abstract

Jintan hitam memiliki berbagai zat berkhasiat, salah satunya adalah thymoquinon sebagai immunodulator, peran-nya terhadap Interleukin-4 dengan subjek uji klinis fase 2 sebagai sitokin anti-inflamasi yaitu dengan menghambat prostaglandin tipe E2 dari asam arakidonat melalui hambatan induksi terhadap cyclooxigenase-2. Bertujuan untuk mengetahui bagaimana pengaruh dari Minyak Biji Jinten Hitam dalam meningkatkan kadar Interleukin-4. Merupakan penelitian Randomized Clinical Trial sebanyak 39 partisipan sehat perokok aktif dengan usia >18 tahun. Dibagi 4 kelompok, yaitu Kelompok 1 diberikan plasebo 3×1 kapsul/hari, kelompok 2, 3, dan 4 diberikan Minyak Biji Jinten Hitam 3×1, 3×2, dan 3×3 kapsul/hari yang diberikan selama 30 hari. Persentase IL-4 menggunakan metode ELISA. Hasil penelitian dianalisis dengan menggunakan metode One Way Annova, dengan nilai–p secara berurutan (0,281 dan 0,860) >0,05 yang berarti terdapat perbedaan yang tidak bermakna antar tiap kelompok perlakuan. Berdasarkan nilai rata-rata persentase Interleukin-4, terjadi peningkatan pada kelompok perlakuan MBJH 3×1 kapsul/hari sebesar 16,566% dibandingkan kelompok plasebo 3×1 kapsul/hari sebesar 13,995%.

References

[1] A. T. Vu, K. M. Taylor, M. R. Holman, Y. S. Ding, B. Hearn, and H. Clifford, 2015, “Polycyclic Aromatic Hydrocarbons in the Mainstream Smoke of Popular U . S . Cigarettes,” Chem. Res. Toxicol., pp. 1–12, 2015, doi: doi:10.1021/acs.chemrestox.5b00190.

[2] J. Drope, N. Schluger, and Z. Cahn, 2018, “The Tobacco Atlas. Atlanta: American Cancer Society and Vital Strategies. American Cancer Society.” Inc,.

[3] F. Qiu, C. Liang, H. Liu, Y. Zeng, and S. Hou, 2017 “Impacts of cigarette smoking on immune responsiveness?: Up and down or upside down??,” impact journals, vol. 8, no. 1, pp. 268–284, doi: 10.1021/acs.chemrestox.5b00190.

[4] M. Laan, S. Bozinovski, and G. P. Anderson, 2004, “Cigarette Smoke Inhibits Lipopolysaccharide-Induced Production of Inflammatory Cytokines by Suppressing the Activation of Activator Protein-1 in Bronchial Epithelial Cells,” J. Immunol., vol. 173, no. 6, pp. 4164–4170, doi: 10.4049/jimmunol.173.6.4164.

[5] B. B. Montano-Velazquez et al., 2016, “Effect of cigarette smoke on counts of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa in young patients with perennial allergic rhinitis,” Braz. J. Otorhinolaryngol., vol. 83, no. 4, pp. 420–425, 2017, doi: 10.1016/j.bjorl.04.011.

[6] F. Qiu et al., 2017 “Oncotarget 268 www.impactjournals.com/oncotarget Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?,” Oncotarget, vol. 8, no. 1, pp. 268–284,.

[7] M. Zhang, Y. Wan, Y. Jin, J. Xin, J. Zhang, and X. Xiong, 2014,“Cigarette Smoking Promotes Inflammation in Patients with COPD by Affecting the Polarization and Survival of Th / Tregs through Up-Regulation of Muscarinic Receptor 3 and 5 Expression,” PLoS One, vol. 9, no. 11, pp. 1–17, doi: 10.1371/journal.pone.0112350.

[8] M. Jeyanathan et al., 2013,“Pulmonary M . tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen- presenting cells,” Nat. Publ. Gr., vol. 7, no. 3, pp. 670–683, 2013, doi: 10.1038/mi.2013.86.

[9] M. A. El Gazzar, R. El Mezayen, M. R. Nicolls, and S. C. Dreskin, 2007, “Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation,” Biochim. Biophys. Acta, vol. 1770, pp. 556–564, doi: 10.1016/j.bbagen.2007.01.002.

[10] M. Nurul, E. Darmawan, F. Farmasi, U. Ahmad, J. P. Soepomo, and S. H. J. Yogyakarta, 2016, “Efek Pemberian Minyak Biji Jinten Hitam ( Nigella sativa L) terhadap Kadar Interleukin-4 dan Proteinuria pada Pasien Beresiko Sindrom Metabolik di PUSKESMAS JETIS I BANTUL 2016,” Asos. Progr. Pascasarj. Perguru. Tinggi Muhammadiyah ‘Aisyiyah 53, vol. 7, pp. 53–64,.

[11] A. Amir, Juniadi, and Yulmardi, Metodologi Penelitian Ekonomi dan Penerapannya. 2009.

[12] I. G. N. E. Putra, N. N. A. Artini, and I. W. G. Artawan, 2016,“Hubungan Karakteristik Dan Tingkat Pengetahuan Mengenai Bahaya Merokok Terhadap Perilaku Merokok Pada Laki-Laki di Provinsi Bali,” Bimkmi, vol. 4, no. 1, pp. 22–30,

[13] Y. Hudaya, 2018, “Hubungan Gambar Bahaya Merokok Pada Kemasan dengan Intensi Berhenti Merokok di Kecamatan Curug Kabupaten Tanggerang,” Jsk, vol. 4, no. 2, pp. 71–77, doi: doi.org/10.24198/jsk.v4i2.20686.

[14] M. Garcia-prat et al., 2018, “Extended Immunophenotyping Reference Values in a Healthy Pediatric Population,” Cytom. Part B - Clin. Cytom., vol. 96, no. 3, pp. 4–10, doi: 10.1002/cyto.b.21728.

[15] R. V. Suryadinata, 2018, “Pengaruh Radikal Bebas Terhadap Proses Inflamasi pada Penyakit Paru Obstruktif Kronis ( PPOK ) Effect of Free Radicals on Inflammatory Process in Chronic Obstructive Pulmonary Disease ( COPD ),” SA Licens., pp. 317–324, doi: 10.20473/amnt.v2.i4.2018.317-324.

[16] C. A. Pope III et al., 2009, “Epidemiology and Prevention Cardiovascular Mortality and Exposure to Airborne Fine Particulate Matter and Cigarette Smoke,” ahajournals.org, vol. 120, no. 11, pp. 941–948, doi: 10.1161/ CIRCULATION AHA.109.857888.

[17] A. S. Gershon, C. Wang, A. S. Wilton, R. Raut, and T. To, 2010, “Trends in chronic obstructive pulmonary disease prevalence, incidence, and mortality in Ontario, Canada, 1996 to 2007: a population-based study,” Arch. Intern. Med., vol. 170, no. 6, pp. 560–565,.

[18] A. Rosengren, L. Wilhelmsen, and H. Wedel, 1992, “Coronary heart disease, cancer and mortality in male middle?aged light smokers,” J. Intern. Med., vol. 231, no. 4, pp. 357–362,.

[19] Ratri Saumi, 2011, “Efektivitas Fitoterapi Jintan Hitam (Nigella Sativa) pada Pasien Hipertensi Tahap 1, Tesis,” Univ. Hasanuddin,Makassar, pp. 17–46,.

[20] M. Boskabady, R. Keyhanmanesh, S. Khameneh, Y. Doostdar, and M. Khakzad, 2011, “Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs,” J. Zhejiang Univ. B, vol. 12, no. 3, pp. 201–209, doi: 10.1631/jzus.B1000163.

[21] A. M. Salem et al., 2017, “Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial,” ANN SAUDI MED 2017, vol. 37, no. 1, pp. 64–71, doi: 10.1186/ISRCTN48853858.

[22] M. L. Salem, 2005, “Immunomodulatory and therapeutic properties of the Nigella sativa L. seed,” Int. Immunopharmacol., vol. 5, no. 13–14, pp. 1749–1770, doi: 10.1016/j.intimp.2005.06.008.

[23] W. Barlianto, M. Rachmawati, M. Irawan, and D. Wulandari, 2017, “Effects of Nigella sativa oil on Th1/Th2, cytokine balance, and improvement of asthma control in children,” Paediatr Indones, vol. 57, no. 5, pp. 223–228,.

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Published

2024-11-14

Issue

Vol. 3 No. 6 (2021): J. Sains Kes.

Section

Articles

How to Cite

[1]
T. . Rachmayani, A. Akrom, and T. . Hidayati, “Pengaruh Minyak Biji Jinten Hitam (Nigella sativa L) terhadap Kadar Interleukin-4”, J. Sains. Kes, vol. 3, no. 6, pp. 773–780, Nov. 2024, Accessed: Jul. 14, 2026. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/428

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