Analisis Faktor yang Berhubungan dengan Potensi Interaksi Obat Pasien Covid-19 di Salah Satu Rumah Sakit Kalimantan Selatan: Factors Associated with Potential Drug Interactions in Covid-19 Hospitalized Patients

Okta Muthia  Sari; Aditya Maulana Perdana  Putra; Yusrinie  Wasiaturrahmah; Nahdiya  Rahmah

doi:10.30872/jsk.v5i5.441

Authors

Okta Muthia Sari Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author
Aditya Maulana Perdana Putra Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author
Yusrinie Wasiaturrahmah Program Studi Kedokteran Gigi, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat, Indonesia Author
Nahdiya Rahmah Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i5.441

Keywords:

COVID-19, faktor berhubungan, interaksi obat, potensi

Abstract

Tatalaksana pengobatan pada pasien COVID-19 diberikan antivirus, terapi suportif dan terapi simptomatik. Penggunaan beberapa jenis obat tersebut membuat pasien COVID-19 berpotensi mengalami interaksi obat. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit. Penelitian obeservasional retrospektif cross sectional ini dilaksanakan di salah satu rumah sakit Kalimantan Selatan. Sampel yakni rekam medis pasien COVID-19 yang mendapat terapi dan rawat inap di rumah sakit periode Januari-Maret 2021 Instrumen penelitian mengkaji potensi dan mekanisme interaksi obat meliputi situs IBM Micromedex , DrugBank Interaction Checker dan Stockley Drug Interactions 9th Edition. Hasil diperoleh sebanyak 82 rekam medis dianalisis potensi interaksi obat. Persentase pasien mengalami potensi interaksi obat sebesar 69,5%. pada pasien COVID-19 rawat inap di rumah sakit. Mekanisme interaksi obat pada pada pasien COVID-19 pada berpotensi pada fase farmakokinetika. Faktor berhubungan potensi interaksi obat pasien COVID-19 yakni usia (p=0.034; OR 0.327, CI 0.11-0.94), jumlah obat yang digunakan selama dirawat (p=0.002; OR 14.00, CI 1.76-111.11) dan lama dirawat (p=0.000; OR 0.009 , CI 0.001-0.07). Kesimpulan, faktor berhubungan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit meliputi usia, jumlah obat yang digunakan selama dirawat dan lama dirawat.

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