Pengaruh Suplementasi Vitamin D Terhadap Kualitas Hidup Dan Reaksi Obat Yang Merugikan (Adverse Drug Reactions) Pada Pasien Hiv/Aids: Studi Pra Dan Pasca Intervensi

The Effect of Vitamin D Supplementation on Quality of Life and Adverse Drug Reactions in Patients with HIV/AIDS: A Pre- and Post-Intervention Study

Authors

  • Ariska Wigatiningtyas Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan Samarinda, Indonesia Author
  • Dyah Ayu Sudarmawan Program Studi Magister Administrasi Rumah Sakit, Fakultas Kedokteran, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia Author
  • Muh. Deni Kurniawan Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author https://orcid.org/0000-0002-9888-8743
  • M. Wahyu Ariawan Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Erfan Abdissalam Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Juliyanti Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v7i2.989

Keywords:

HIV, kualitas hidup, vitamin D, terapi antiretroviral , adverse drug reactions

Abstract

Latar Belakang: Infeksi Human Immunodeficiency Virus (HIV) masih menjadi masalah kesehatan global. Terapi antiretroviral (ARV) efektif meningkatkan harapan dan kualitas hidup pasien, namun sering disertai reaksi obat yang merugikan (adverse drug reactions/ADR) yang dapat menurunkan kenyamanan dan kepatuhan terapi. Suplementasi vitamin D berpotensi menjadi terapi adjuvan karena perannya sebagai imunomodulator dan pengaruhnya terhadap fungsi fisik serta psikologis pasien HIV.

Tujuan: Penelitian ini bertujuan menganalisis pengaruh suplementasi vitamin D terhadap kualitas hidup dan kejadian ADR pada pasien HIV/AIDS yang menjalani terapi ARV.

Metode: Penelitian kuantitatif dengan desain pra-eksperimental one group pretest–posttest dilakukan di Puskesmas Rapak Mahang, Kabupaten Kutai Kartanegara. Sebanyak 32 pasien HIV diikutsertakan. Kualitas hidup diukur menggunakan WHOQOL-HIV BREF sebelum dan sesudah suplementasi vitamin D selama delapan minggu. Kejadian ADR dinilai melalui pemantauan terstruktur. Analisis statistik menggunakan uji Wilcoxon signed-rank dan uji McNemar.

Hasil: Seluruh responden berada dalam kondisi imunologis stabil (CD4 >500 sel/µL). Setelah intervensi, terjadi peningkatan bermakna pada domain fisik, psikologis, dan kemandirian serta kualitas hidup global (p < 0,001), disertai penurunan signifikan ADR gastrointestinal dan neurologi/psikologis (p ≤ 0,001).

Kesimpulan: Suplementasi vitamin D berasosiasi dengan perbaikan kualitas hidup dan penurunan ADR tertentu pada pasien HIV yang menjalani terapi ARV, serta berpotensi sebagai terapi adjuvan.

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Published

2026-05-29

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Vol. 7 No. 2 (2026): J. Sains Kes.

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How to Cite

[1]
Ariska Wigatiningtyas, Dyah Ayu Sudarmawan, Muh. Deni Kurniawan, M. Wahyu Ariawan, Erfan Abdissalam, and Juliyanti, “Pengaruh Suplementasi Vitamin D Terhadap Kualitas Hidup Dan Reaksi Obat Yang Merugikan (Adverse Drug Reactions) Pada Pasien Hiv/Aids: Studi Pra Dan Pasca Intervensi: The Effect of Vitamin D Supplementation on Quality of Life and Adverse Drug Reactions in Patients with HIV/AIDS: A Pre- and Post-Intervention Study”, J. Sains. Kes, vol. 7, no. 2, pp. 74–81, May 2026, doi: 10.30872/jsk.v7i2.989.

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