Peran Disregulasi Imunitas dalam Terapi Kusta pada Area Endemis: Artikel Review: The Role of Immune Dysregulation in Leprosy Treatment in Endemic Areas: Review Article

Flora Ramona Sigit Prakoeswa; Faradiba Maharani

Authors

Flora Ramona Sigit Prakoeswa Dermatology and Venereology Departement, Medical Faculty of Universitas Muhammadiyah Surakarta, Indonesia Author
Faradiba Maharani Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Author

Keywords:

kusta, disregulasi imunitas, terapi kusta

Abstract

Kusta, penyakit menular kronis yang disebabkan oleh Mycobacterium leprae, masih menimbulkan masalah kesehatan dan menjadi endemis di beberapa negara. Jumlah kasus kusta baru masih dilaporkan di negara endemis secara konstan. Upaya terapi pada pasien kusta dilakukan dengan tujuan menurunkan tingkat penularan dan kecacatan penderita kusta. Terapi kusta dengan penggunaan regimen multidrug (MDT) terbukti mampu menurunkan jumlah kasus kusta namun belum dapat menekan laju pertumbuhan kasus kusta baru. Jumlah kasus kusta baru yang bersifat konstan di area endemis menunjukkan terdapat infeksi komunitas dan ketidakmampuan MDT sebagai strategi tunggal untuk menyelesaikan pengobatan dan menghentikan penularan kusta. Penularan penyakit kusta diketahui bersifat multifaktorial yang melibatkan: faktor mikroba, faktor pejamu, dan faktor lingkungan. Faktor-faktor tersebut diduga dapat menyebabkan disregulasi imunitas dan meningkatkan risiko infeksi kusta pada penduduk yang tinggal di daerah endemis. Pemahaman mengenai disregulasi imunitas diperlukan untuk menyelesaikan pengobatan dan pemberantasan
kusta.

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Peran Disregulasi Imunitas dalam Terapi Kusta pada Area Endemis: Artikel Review

The Role of Immune Dysregulation in Leprosy Treatment in Endemic Areas: Review Article

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