Aktivitas Anti-Inflamasi Ekstrak Etanol Daun Mekai (Albertisia papuana Becc.) Pada Kaki Tikus Wistar Jantan Yang Diinduksi Karagenan

Anti-Inflammatory Activity of Mekai Leaves (Albertisia papuana Becc.) Ethanol Extract of Carrageenan-Induced Paw Edema In Male Wistar Rats

Authors

  • Satriani Badawi Fakultas Farmasi Universitas Mulawarman Author
  • Putri Anggreini Author
  • Noviyanti Indjar Gama Author
  • Helmi Helmi Author
  • Nur Rezky Khairun Nisaa Author

DOI:

https://doi.org/10.30872/jsk.v6i2.750

Keywords:

Albertisia papuana, aktivitas antiinflamasi, karegenan

Abstract

Inflamasi merupakan tanda kerusakan jaringan yang dapat disebabkan oleh patogen ataupun trauma. Metabolit sekunder Albertisi papuana terbukti memiliki aktivitas antibakteri, antifungi dan antiplasmodial. Daun ini juga diduga memiliki antioksidan yang mampu berperan sebagai antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui aktivitas antiinflamsi ekstrak etanol A. papuana. Tikus wistar dibagi menjadi 5 kelompok yaitu kelompok N, C, C+SDc, APE125 dan APE500. Telapak kaki kiri tikus diinduksi karagenan 1% sebagi agen induksi inflamasi. Volume udem awal (V0) dan pemberian ekstrak dilakukan 1 jam sebelum induksi karagenan. Perubahan volume udem diukur setiap 1 jam selama 6 jam. Setelah itu hewan didislokasi, kaki dipotong dan ditimbang beratnya. Hasil pengujian ANOVA menunjukkan peningkatan berat kaki pada kelompok kontrol (P<0.018). Persentase inhibisi inflamasi kelompok kontrol C+SDc 46.43%, kelompok APE125 39.33% dan kelompok APE500 20.44%. Senyawa flavonoid dan fenolik diduga berperan dalam penurunan volume udem dan peningkatan persentase inhibisi inflamasi pada hewan uji.

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Published

2025-12-23

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Vol. 6 No. 2 (2025): J. Sains Kes.

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How to Cite

[1]
S. Badawi, Putri Anggreini, Noviyanti Indjar Gama, Helmi Helmi, and Nur Rezky Khairun Nisaa, “Aktivitas Anti-Inflamasi Ekstrak Etanol Daun Mekai (Albertisia papuana Becc.) Pada Kaki Tikus Wistar Jantan Yang Diinduksi Karagenan: Anti-Inflammatory Activity of Mekai Leaves (Albertisia papuana Becc.) Ethanol Extract of Carrageenan-Induced Paw Edema In Male Wistar Rats”, J. Sains. Kes, vol. 6, no. 2, pp. 54–60, Dec. 2025, doi: 10.30872/jsk.v6i2.750.

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