Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon

Authors

  • Arfiani Arifin Program Studi Farmasi, Fakultas MIPA, Universitas Islam Makassar Author
  • Sartini Sartini Fakultas Farmasi, Universitas Hasanuddin Author
  • Marianti Marianti Fakultas Farmasi, Universitas Hasanuddin Author

Keywords:

aspirin, patch, etilselulosa, PVP K-30

Abstract

Penelitian ini bertujuan mengetahui kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik dan pengaruhnya terhadap permeasi kulit pada hewan coba.Pengujian yang dilakukan meliputi pengujian fisik yaitu uji organoleptik, kadar air, ketebalan, dan keseragaman bobot, serta uji permeasi kulit pada hewan coba menggunakan membran kulit tikus dan kelinci. Perbandingan formulasi etilselulosa dan PVP K-30 yang digunakan adalah 7:3 (F1), 8:2 (F2) dan9:1 (F3). Patch dibuat dengan menggunakan metode solvent casting atau dikenal metode cetak tuang. Hasil penelitian menunjukkan bahwa kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik adalah F2 (8:2) dan F3(9:1). Berdasarkan hasil pengujian terhadap uji permeasi menggunakan membran kulit tikus dan kelinci dapat disimpulkan bahwa formula optimum yaitu F3 (9:1) dengan nilai permeasi tertinggi pada tikus 46,09% dan kelinci 66,30 %.

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Published

2024-11-14

Issue

Vol. 2 No. 1 (2019): J. Sains Kes.

Section

Articles

How to Cite

[1]
A. Arifin, S. Sartini, and M. Marianti, “Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon”, J. Sains. Kes, vol. 2, no. 1, pp. 40–49, Nov. 2024, Accessed: Oct. 03, 2025. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/44

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