Toxicity of Anti-Inflammatory Substances in Hemigraphis Alternata Leaves: In Silico Study Using ProTox-II

Authors

  • Yeni Yeni Department of Pharmacy, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia Author https://orcid.org/0000-0001-9042-4824
  • Rizky Arcinthya Rachmania Department of Pharmacy, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i5.564

Keywords:

in silico, toxicity, Hemigraphis alternata, anti-inflammatory, ProTox-II

Abstract

Hemigraphis alternata is empirically used to treat wounds. Hemigraphis alternata leaves ethyl acetate extract can assist in resolving the inflammatory process by inhibiting enzymes that play a role in the inflammatory cycle. Twenty-two substances found in the leaves of Hemigraphis alternata were predicted to have an anti-inflammatory effect by inhibiting cyclooxygenase-1 (COX-1) or 5-lipoxygenase (5-LOX) as an enzyme target. In-silico toxicology was carried out to acquire new anti-inflammatory drugs with low toxicity from 22 compounds. ProTox-II was utilized to measure the level of toxicity of these drugs at many endpoints. In this study, five compounds have LD50 > 5000 mg/kg body weight, toxicity class 5-6, and inactive for cytotoxicity, carcinogenicity, hepatotoxicity, mutagenicity and immunotoxicity parameters. They are 2-methyleneoctanenitrile, nerolidol, 2,7-dioxa-tricyclo[4.4.0.0(3,8)]deca-4,9-diene, 9,9-dimethoxybicyclo[3.3.1]nonane-2,4-dione, and phytol.

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Published

2024-11-15

Issue

Vol. 5 No. 5 (2023): J. Sains Kes.

Section

Articles

How to Cite

[1]
Y. Yeni and R. A. . Rachmania, “Toxicity of Anti-Inflammatory Substances in Hemigraphis Alternata Leaves: In Silico Study Using ProTox-II”, J. Sains. Kes, vol. 5, no. 5, pp. 810–815, Nov. 2024, doi: 10.30872/jsk.v5i5.564.
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