Pengaruh Suplementasi Vitamin D Terhadap Kualitas Hidup Dan Reaksi Obat Yang Merugikan (Adverse Drug Reactions) Pada Pasien Hiv/Aids: Studi Pra Dan Pasca Intervensi
The Effect of Vitamin D Supplementation on Quality of Life and Adverse Drug Reactions in Patients with HIV/AIDS: A Pre- and Post-Intervention Study
DOI:
https://doi.org/10.30872/jsk.v7i2.989Keywords:
HIV, kualitas hidup, vitamin D, terapi antiretroviral , adverse drug reactionsAbstract
Tujuan: Penelitian ini bertujuan menganalisis pengaruh suplementasi vitamin D terhadap kualitas hidup dan kejadian ADR pada pasien HIV/AIDS yang menjalani terapi ARV.
Metode: Penelitian kuantitatif dengan desain pra-eksperimental one group pretest–posttest dilakukan di Puskesmas Rapak Mahang, Kabupaten Kutai Kartanegara. Sebanyak 32 pasien HIV diikutsertakan. Kualitas hidup diukur menggunakan WHOQOL-HIV BREF sebelum dan sesudah suplementasi vitamin D selama delapan minggu. Kejadian ADR dinilai melalui pemantauan terstruktur. Analisis statistik menggunakan uji Wilcoxon signed-rank dan uji McNemar.
Hasil: Seluruh responden berada dalam kondisi imunologis stabil (CD4 >500 sel/µL). Setelah intervensi, terjadi peningkatan bermakna pada domain fisik, psikologis, dan kemandirian serta kualitas hidup global (p < 0,001), disertai penurunan signifikan ADR gastrointestinal dan neurologi/psikologis (p ≤ 0,001).
Kesimpulan: Suplementasi vitamin D berasosiasi dengan perbaikan kualitas hidup dan penurunan ADR tertentu pada pasien HIV yang menjalani terapi ARV, serta berpotensi sebagai terapi adjuvan.
References
[1.] R. E. S. Anglin, Z. Samaan, S. D. Walter, and S. D. McDonald, “Vitamin D deficiency and depression in adults: Systematic review and meta-analysis,” The British Journal of Psychiatry, vol. 202, no. 2, pp., 2013.
[2.] P. Autier, M. Boniol, C. Pizot, and P. Mullie, “Vitamin D status and ill health: A systematic review,” The Lancet Diabetes & Endocrinology, vol. 5, no. 6, pp, 2017.
[3.] B. Ayelign, M. Workneh, M. D. Molla, and G. Dessie, “Role of vitamin D supplementation in TB/HIV co-infected patients,” Infection and Drug Resistance, vol. 13, pp. 111–118, 2020, doi: 10.2147/IDR.S228336.
[4.] K. Bourgi et al., “Greater weight gain in treatment-naïve persons starting dolutegravir-based antiretroviral therapy,” Clinical Infectious Diseases, vol. 70, no. 7, pp. 1267–1274, 2020.
[5.] T. T. Brown and G. A. McComsey, “Vitamin D deficiency and its association with bone health in HIV infection,” Journal of Acquired Immune Deficiency Syndromes, vol. 55, no. 5, pp. 551–559, 2010.
[6.] S. Degroote, D. Vogelaers, and D. M. Vandijck, “What determines health-related quality of life among people living with HIV: An updated review of the literature,” Archives of Public Health, vol. 72, no. 1, p. 40, 2014.
[7.] N. Natasya, S. N. Maharani, and M. Misna, “HIV/AIDS: Update terkini di Indonesia,” Protein: Jurnal Ilmu Keperawatan dan Kebidanan, vol. 3, no. 1, pp. 27–36, 2024, doi: 10.61132/protein.v3i1.918.
[8.] World Health Organization, Update of Recommendations on First- and Second-Line Antiretroviral Regimens. Geneva, Switzerland: WHO, 2019
[9.] L. Eka Skripsiwati, S. Bachri, and Kemenkes Malang, “Hubungan dukungan keluarga dengan kepatuhan minum ARV (antiretroviral) pada ibu balita ODHIV,” Jurnal Inovasi Riset Ilmu Kesehatan, vol. 4, no. 3, 2025.
[10.] International Labour Organization, Flipchart HIV dan AIDS. Geneva, Switzerland: ILO, 2011.
[11.] Kementerian Kesehatan Republik Indonesia, Peraturan Menteri Kesehatan Republik Indonesia Nomor 23 Tahun 2022, Jakarta, Indonesia, 2022.
[12.] Kementerian Kesehatan Republik Indonesia, Pedoman Pengobatan Antiretroviral (Permenkes RI No. 87 Tahun 2014), Jakarta, Indonesia, 2014.
[13.] J. E. Lake and J. S. Adams, “Vitamin D in HIV-infected patients,” Current HIV/AIDS Reports, vol. 8, no. 3, pp. 2011.
[14.] World Health Organization, WHOQOL-HIV Instrument: Users Manual. Geneva, Switzerland: WHO, 2002
[15.] M. T. May et al., “Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy,” AIDS, vol. 28, no. 8, pp. 2014.
[16.] M. G. Nanni, R. Caruso, A. J. Mitchell, E. Meggiolaro, and L. Grassi, “Depression in HIV infected patients: A review,” Current Psychiatry Reports, vol. 17, no. 1, p. 530, 2015.
[17.] W. D. F. Venter et al., “Dolutegravir plus two different prodrugs of tenofovir to treat HIV,” New England Journal of Medicine, vol. 381, no. 9, pp. 803–815, 2019.M. F. Holick, “The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention,” Reviews in Endocrine and Metabolic Disorders, vol. 18, no. 2, pp. 2017.
[18.] K. A. O’Connell and S. M. Skevington, “The relevance of spirituality, religion and personal beliefs to health-related quality of life,” British Journal of Health Psychology, vol. 17, no. 2, pp. 379–398, 2012.
[19.] S. Pilz et al., “Vitamin D testing and treatment: A narrative review of current evidence,” Endocrine Connections, vol. 8, no. 2, pp. R27–R43, 2019.
[20.] F. Vellekkatt and V. Menon, “Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials,” Journal of Postgraduate Medicine, vol. 65, no. 2, pp. 74–80, 2019.
[21.] R. Qurban, S. Saeed, W. Kanwal, K. Junaid, and A. Rehman, “Potential immune modulatory effect of vitamin D in HIV infection: A review,” Clinical Nutrition ESPEN, vol. 47, pp. 2022, doi: 10.1016/j.clnesp.2021.12.005.
[22.] U. Utia Jahro et al., “Analisis faktor yang mempengaruhi kualitas hidup orang dengan HIV/AIDS (ODHA) di Puskesmas Serang Kota,” 2023.
[23.] A. Trickey et al., “Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013,” The Lancet HIV, vol. 4, no. 8, pp. e349–e356, 2017.
[24.] M. F. Holick, “The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention,” Reviews in Endocrine and Metabolic Disorders, vol. 18, no. 2, pp. 2017.
[25.] C. M. Puchalski, R. Vitillo, S. K. Hull, and N. Reller, “Improving the spiritual dimension of whole person care,” Journal of Palliative Medicine, vol. 17, no. 6, pp. 642–656, 2014.
[26.] World Health Organization, HIV Statistics, Globally and by WHO Region 2025. Geneva, Switzerland: WHO, 2025
[27.] A. Hawais Monasel et al., “Faktor-faktor yang berhubungan dengan kualitas hidup orang dengan HIV/AIDS (ODHA) di Yayasan Sehat Peduli Kasih Kota Semarang,” 2019.
[28.] Anand D, Puri S, Mathew M. Assessment of Quality of Life of HIV-Positive People Receiving ART: An Indian Perspective. Indian J Community Med. 2012 Jul;37(3):165-9. doi: 10.4103/0970-0218.99918. PMID: 23112442; PMCID: PMC3483509.
[29.] Jiménez-Sousa MÁ, Martínez I, Medrano LM, Fernández-Rodríguez A, Resino S. Vitamin D in Human Immunodeficiency Virus Infection: Influence on Immunity and Disease. Front Immunol. 2018 Mar 12;9:458. doi: 10.3389/fimmu.2018.00458. PMID: 29593721; PMCID: PMC5857570.
[30.] Tabatabaeizadeh SA, Tafazoli N, Ferns GA, Avan A, Ghayour-Mobarhan M. Vitamin D, the gut microbiome and inflammatory bowel disease. J Res Med Sci. 2018 Aug 23;23:75. doi: 10.4103/jrms.JRMS_606_17. PMID: 30181757; PMCID: PMC6116667.
[31.] Vergori A, Pinnetti C, Lorenzini P, Brita A, Libertone R, Mastrorosa I, Cicalini S, Antinori A, Ammassari A. Vitamin D deficiency is associated with neurocognitive impairment in HIV-infected subjects. Infection. 2019 Dec;47(6):929-935. doi: 10.1007/s15010-019-01313-6. Epub 2019 Jun 10. PMID: 31183805.
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