Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) sebagai Antiinflamasi Metode CarrageenanInduced Air Pouch

The Effect of Administering Ethanolic Extract Gel from Ekor Naga(Rhaphidophora pinnata (L.f) Schott) Leaves as an Anti-InflammationCarrageenan-Induced Air Pouch Method

Authors

  • Fathnur Sani K Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi, Indonesia Author
  • Kristin Simamora Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi, Indonesia Author
  • Havizur Rahman Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi, Indonesia Author
  • Ave Olivia Rahman Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi, Indonesia Author
  • Yuliawati Yuliawati Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi, Indonesia Author

DOI:

https://doi.org/10.30872/jsk.v5i5.426

Keywords:

Daun Ekor Naga, Gel, Inflamasi, Air Pouch

Abstract

Ekstrak etanol daun ekor naga  (Rhaphidophora pinnata (L.f) Schott) telah diteliti memiliki efek sebagai agen antiinflamasi. Penenlitian ini bertujuan untuk memformulasi sediaan topikal gel ekstrak daun ekor naga sehingga dapat menjadi menjadi langkah lanjut dari penelitian sebelumnya sebagai upaya pengembangan produk. Metode penelitian yang digunakan adalah experimental design. Kelompok perlakuan dibagi menjadi lima kelompok yaitu: Kontrol positif (Hidrokortisone), Formula 0 (Basis Gel), Formula 1 (Konsentrasi Ekstrak 10%), Formula 2 (Konsentrasi Ekstrak 15%), dan Formula 3 (Konsentrasi Ekstrak 20%). Hewan uji yang digunakan masing-masing kelompok perlakuan 5 ekor. Data yang didapat dianalisis menggunakan ANOVA satu arah dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa semakin banyak ekstrak maka semakin baik efek antiinflamasinya. Namun berdasarkan data evaluasi sediaan pada penelitian sebelumnya tentang formulasi gel maka disimpulkan bahwa formula 2 merupakan formula terbaik dengan efek yang secara statistic hampir sama dengan formula 3 serta memiliki stabilitas gel yang baik dalam formulasi.

References

S. Sumayyah and N. Salsabila, “Obat Tradisional?: Antara Khasiat dan Efek Sampingnya,” Farmasetika.com (Online), vol. 2, no. 5, 2017, doi: 10.24198/farmasetika.v2i5.16780.

A. B. Pratama, Khasiat Tanaman Obat Herbal. 2021.

F. S. K, H. Rahman, A. O. Rahman, A. G. Samudra, and C. De Floris, “Incision wound healing test ethanolic extract gel from Ekor Naga ( Rhaphidophora pinnata ( L . f ) Schott ) leaves in white male rats,” vol. 12, no. 2, 2022, doi: 10.12928/pharmaciana.v12i2.22825.

L. Chen et al., “Inflammatory responses and inflammation-associated diseases in organs,” Oncotarget, vol. 9, no. 6. 2018, doi: 10.18632/oncotarget.23208.

G. Alderton and S. T. Scanlon, “Inflammation,” Science (New York, N.Y.), vol. 374, no. 6571. 2021, doi: 10.1126/science.abn1721.

B. A. Tarigan and F. S. K, “Topical anti-inflammatory effect of Ekor Naga ( Rhaphidophora pinnata ( L . f ) Schott ) leaves extract,” vol. 11, no. 3, pp. 303–311, 2021, doi: 10.12928/pharmaciana.v11i3.17617.

Y. P. Kenisa, I. Istiati, and W. S. J, “Effect of Robusta coffee beans ointment on full thickness wound healing,” Dent. J. (Majalah Kedokt. Gigi), vol. 45, no. 1, 2012, doi: 10.20473/j.djmkg.v45.i1.p52-57.

W. Borgi, M. C. Recio, J. L. Ríos, and N. Chouchane, “Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam.,” South African J. Bot., vol. 74, no. 2, pp. 320–324, 2008, doi: 10.1016/j.sajb.2008.01.009.

P. Yamlean, Y., V, Buku Ajar Farmasetika. 2020.

A. Oryan, A. Mohammadalipour, A. Moshiri, and M. R. Tabandeh, “Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling: An Experimental Study With Significant Clinical Value.,” Ann. Plast. Surg., vol. 00, no. 00, 2014.

F. Sani K, H. Rahman, and A. O. Rahman, “Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott).”

M. Aria, V. Verawati, A. Arel, and M. Monika, “Uji Efek Antiinflamasi Fraksi Daun Piladang (Solenostemonscutellarioides (L.) Codd) terhadap Mencit Putih Betina,” Sci. J. Farm. dan Kesehat., 2015, doi: 10.36434/scientia.v5i2.27.

J. C. Fehrenbacher and K. E. McCarson, “Models of Inflammation: Carrageenan Air Pouch,” Curr. Protoc., vol. 1, no. 8, 2021, doi: 10.1002/cpz1.183.

M. Aria, V. Verawati, A. Arel, and M. Monika, “Uji Efek Antiinflamasi FraksiDaun Piladang (Solenostemonscutellarioides (L.) Codd) terhadap Mencit Putih Betina,” Scientia, vol. 5, no. 2, pp. 84–91, 2015.

D. Dillasamola, S. Dharma, Y. ALdi, I. Berd, A. Hadyan, and B. P. Oktomalio, “Anti-inflammatory Effect Test of Ethanol Extract of Mistletoe Leaves Coffee Scurrula ferruginea(Jack) Danser With Methods Granuloma Pouch,” DermatologyPharma Chem., vol. 8, no. 19, pp. 301–304, 2016.

B. A. Tarigan, UJI AKTIVITAS ANTIINFLAMASI EKTRAK DAUN EKOR NAGA (Rhaphidophora pinnata(L.f) Schott)PADAMENCIT PUTIH JANTAN [Skripsi]. Jambi: Universitas Jambi, 2020.

Masfria, Sumaiyah, and A. Dalimunthe, “Antimutagenic activity of ethanol extract of Rhaphidophora pinnata (L.f) schott leaves on mice,” Sci. Pharm., 2017, doi: 10.3390/scipharm85010007.

D. Lestari, I. Lestari, and F. S. K, “Uji efektivitas ekstrak etanol daun ekor naga (Rhaphidophora pinnata (L.f) Schott) sebagai antihiperglikemia terhadap mencit putih jantan yang diinduksi sukrosa,” J. Ilm. Manuntung, vol. 7, no. 1, pp. 100–110, 2021.

M. Suhail, P. C. Wu, and M. U. Minhas, “Using carbomer-based hydrogels for control the release rate of diclofenac sodium: Preparation and in vitro evaluation,” Pharmaceuticals, vol. 13, no. 11, pp. 1–17, 2020, doi: 10.3390/ph13110399.

R. Y. Astika, F. Sani, and Elisma, “Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) Pada Mencit Putih Jantan,” J. Ilm. Manuntung, vol. 8, no. 1, pp. 14–23, 2022.

S. Baradaran, A. H. Moghaddam, S. K. Jelodar, and N. Moradikor, “Protective effects of curcumin and its nano-phytosome on carrageenan-induced inflammation in mice model: Behavioral and biochemical responses,” J. Inflamm. Res., vol. 13, 2020, doi: 10.2147/JIR.S232462.

J. H. Ahn et al., “Water extract of Artemisia scoparia Waldst. & Kitam suppresses LPS-induced cytokine production and NLRP3 inflammasome activation in macrophages and alleviates carrageenan-induced acute inflammation in mice,” J. Ethnopharmacol., vol. 268, 2021, doi: 10.1016/j.jep.2020.113606.

V. Sabu et al., “Combinatorial Action of Triterpenoid, Flavonoid, and Alkaloid on Inflammation,” Nat. Prod. Commun., vol. 14, no. 8, 2019, doi: 10.1177/1934578X19868877.

L. Benvenutti et al., “Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart .) Bohs,” vol. 2021, 2021.

J. Dong et al., “Saponins regulate intestinal inflammation in colon cancer and IBD,” Pharmacological Research, vol. 144. 2019, doi: 10.1016/j.phrs.2019.04.010.

Y. Shi et al., “The preventive effect of total saponins from Panax japonicus on inflammation and insulin resistance in adipose tissue of mice induced by a high-fat diet,” J. Funct. Foods, vol. 78, 2021, doi: 10.1016/j.jff.2021.104369.

Downloads

Published

2024-11-15

Issue

Vol. 5 No. 5 (2023): J. Sains Kes.

Section

Articles

Deprecated: json_decode(): Passing null to parameter #1 ($json) of type string is deprecated in /home/jskff/public_html/plugins/generic/citations/CitationsPlugin.php on line 68

How to Cite

[1]
F. S. . K, K. . Simamora, H. . Rahman, . A. O. . Rahman, and Y. Yuliawati, “Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) sebagai Antiinflamasi Metode CarrageenanInduced Air Pouch: The Effect of Administering Ethanolic Extract Gel from Ekor Naga(Rhaphidophora pinnata (L.f) Schott) Leaves as an Anti-InflammationCarrageenan-Induced Air Pouch Method”, J. Sains. Kes, vol. 5, no. 5, pp. 576–583, Nov. 2024, doi: 10.30872/jsk.v5i5.426.

Similar Articles

141-150 of 226

You may also start an advanced similarity search for this article.