Review: Aktivitas Imunostimulan dari Famili Malvaceae

Review: Immunostimulant Activity from Malvaceae Family

Authors

  • Syifa Rizkia Khoerunisa Prodi S1 Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam. Universitas Garut Author
  • Atun Qowiyyah Prodi S1 Farmasi, Fakultas Matematika dan Imu Pengetahuan Alam. Universitas Garut, Tarogong, Garut, Jawa Barat, Indonesia, 44151 Author
  • Sitti Fatimah Putri Hasyul Prodi S1 Farmasi, Fakultas Matematika dan Imu Pengetahuan Alam. Universitas Garut, Tarogong, Garut, Jawa Barat, Indonesia, 44151 Author

Keywords:

Aktivitas imunosimulan, Imunostimulan, Malvaceae, Respon imun, Sistem imun

Abstract

Pandemi COVID-19 hingga saat ini masih mewabah di seluruh dunia, termasuk Indonesia. Kasus positif COVID-19 per-tanggal 22 juli 2021, di Indonesia sebanyak 3.033.339 jiwa dengan angka kematian 79.032 jiwa. Imunostimulan merupakan zat yang dapat meningkatkan daya tahan tubuh terhadap infeksi, termasuk untuk menangkal infeksi virus corona. Imunostimulan dapat berasal dari bahan sintetis atau bahan alam.  Tanaman famili Malvaceae sering digunakan sebagai obat tradisional untuk mengobati diare, batuk, dan menjaga daya tahan tubuh. Review artikel ini bertujuan untuk memberikan informasi mengenai famili Malvaceae yang memiliki aktivitas imunostimulan. Metode yang digunakan dalam review artikel yaitu studi literatur secara online melalui berbagai database seperti Google Scholar, PubMed, dan ScienceDirect. Hasil review menunjukan tanaman Abelmoschus esculentus, Abelmoschus manihot L., Hibiscus sabdarifa L., Hibiscus rosa-sinensis L., Sterculia villosa Roxb., Luehea divaricata Mart. & Zucc., dan Sida cordifolia, menunjukan aktivitas imunostimulan. Spesies paling berpotensi sebagai agen imunostimulan, yaitu Sterculia villosa Roxb., karena mampu meningkatkan berbagai mediator dan sitokin pada sistem imun, serta telah dilakukan pengujian secara in vitro, in vivo, dan in silico terhadap senyawa lupeol dari Sterculia villosa Roxb., yang mampu meningkatkan daya tahan tubuh terhadap infeksi.

References

H. Kumar, T. Kawai, and S. Akira, “Pathogen recognition by the innate immune system,” Int. Rev. Immunol., vol. 30, no. 1, pp. 16–34, 2011.

N. Nurrahman and M. Mariyam, “Status Hematologi , Kadar IgG dan IgA Tikus yang Mengonsumsi berbagai Variasi Jumlah Tempe Kedelai Hitam,” Agritech, vol. 39, no. 3, pp. 215–221, 2019.

C. Rosales, N. Demaurex, C. A. Lowell, and E. Uribe-Querol, “Neutrophils: Their Role in Innate and Adaptive Immunity,” J. Immunol. Res., vol. 2016, pp. 2–4, 2016.

C. Huang et al., “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China,” Thelancer, vol. 395, pp. 497–506, 2020.

WHO, “WHO COVID-19 global table data July 22nd 2021,” WHO Coronavirus Disease (COVID-19) Dashboard, 2021. https://covid19.who.int/.

S. COVID19, “Data Sebaran COVID19,” covid19, 2021. https://covid19.go.id/peta-sebaran.

Perhimpunan Dokter Paru Indonesia, Peumonia COVID-19. Jakarta: PDPI, 2020.

N. F. E. Pariang et al., Panduan Praktis Untuk Apoteker Menghadapi Pandemi COVID-19, 1st ed. Jakarta, 2020.

E. Elisma, H. Rahman, and U. Lestari, “PPM Pemberdayaan Masyarakat Dalam Pengolahan Tanaman Obat Sebagai Obat Tradisional Di Desa Mendalo Indah Jambi Luar Kota,” SELAPARANG J. Pengabdi. Masy. Berkemajuan, vol. 4, no. 1, p. 274, 2020.

Masadi, “Keanekaragaman Family Malvaceae Di Hutan Taman Eden 100 Sebagai Bahan Perangkat Pembelajaran Biologi,” Best J., vol. 2, no. 2, pp. 32–41, 2019.

H. Pitra, A. Haerullah, and N. Papuangan, “Studi pengetahuan lokal masyarakat moya tentang pemanfaatan tumbuhan sebagai obat tradisional,” J. Saintifika, vol. 1, no. 1, pp. 45–49, 2017.

V. Sabitha, S. Ramachandran, K. R. Naveen, and K. Panneerselvam, “Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats,” J. Pharm. Bioallied Sci., vol. 3, no. 3, pp. 397–402, 2011.

T. Yan et al., “Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota,” Int. J. Biol. Macromol., vol. 144, no. L, pp. 427–440, 2020.

S. C. Sheu and M. H. Lai, “Composition analysis and immuno-modulatory effect of okra (Abelmoschus esculentus L.) extract,” Food Chem., vol. 134, no. 4, pp. 1906–1911, 2012.

X. Pan, J. Tao, S. Jiang, Y. Zhu, D. Qian, and J. Duan, “Characterization and immunomodulatory activity of polysaccharides from the stems and leaves of Abelmoschus manihot and a sulfated derivative,” Int. J. Biol. Macromol., pp. 1–31, 2017.

C. Shen, W. Zhang, and J. Jiang, “Immune-enhancing activity of polysaccharides from Hibiscus sabdariffa Linn . via MAPK and NF-kB signaling pathways in RAW264 . 7 cells,” J. Funct. Foods, vol. 34, pp. 118–129, 2017.

N. Mishra, V. L. Tandon, and R. Gupta, “Immunomodulation by Hibiscus rosa-sinensis: Effect on the Humoral and Cellular Immune Response of Mus Musculus,” Pakistan J. Biol. Sci., vol. 15, no. 6, pp. 277–283, 2012.

A. Das et al., “Antileishmanial and immunomodulatory activity of lupeol a triterpene compound isolated from Sterculia villosa.,” Int. J. Antimicrob. Agents, pp. 1–22, 2017.

R. L. da Rosa et al., “Anti-inflammatory , analgesic , and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark,” Brazilian J. Pharm. Sci., vol. 50, no. 3, pp. 600–610, 2014.

M. Ouedraogo, K. Konaté, A. N. Lepengué, A. Souza, B. M’Batchi, and and L. L. Sawadogo, “Free radical scavenging capacity , anticandicidal effect of bioactive compounds from Sida Cordifolia L ., in combination with nystatin and clotrimazole and their effect on specific immune response in rats,” Ann. Clin. Microbiol. Antimicrob., vol. 11, no. 33, pp. 1–10, 2012.

A. N. M. Ansori, “A mini-review of the medicinal properties of Okra (Abelmoschus esculentus l.) and potential benefit against SARS-CoV-2,” Indian J. Forensic Med. Toxicol., vol. 15, no. 1, pp. 852–856, 2021.

S. K. Doreddula et al., “Nootropic Activities of Aqueous and Methanolic Seed Extracts of Ladies Finger (Abelmoschus esculentus L.) in Mice,” Sci. World J., vol. 2014, pp. 1–14, 2014.

C. C. Pi et al., “Polysaccharides from Ganoderma formosanum function as a Th1 adjuvant and stimulate cytotoxic T cell response in vivo,” Vaccine, vol. 32, no. 3, pp. 401–408, 2014.

A. N. Ilyas, R. Rahmawati, and H. Widiastuti, “Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Gedi (Abelmoschus Manihot L. Medik) Secara In Vitro,” Wind. Heal. J. Kesehat., vol. 3, no. 1, pp. 57–64, 2020.

J. M. Guo et al., “Metabolite identification strategy of non-targeted metabolomics and its application for the identification of components in Chinese multicomponent medicine Abelmoschus manihot L.,” Phytomedicine, vol. 22, no. 5, pp. 579–587, 2015.

G. Ai, Q. Liu, W. Hua, Z. Huang, and D. Wang, “Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies,” J. Ethnopharmacol., vol. 146, no. 3, pp. 794–802, 2013.

S. J. Lee et al., “Immunostimulatory activity of polysaccharides from Cheonggukjang,” Food Chem. Toxicol., vol. 59, pp. 476–484, 2013.

J. E. Li, S. P. Nie, M. Y. Xie, and C. Li, “Isolation and partial characterization of a neutral polysaccharide from Mosla chinensis Maxim. cv. Jiangxiangru and its antioxidant and immunomodulatory activities,” J. Funct. Foods, vol. 6, no. 1, pp. 410–418, 2014.

P. A. Hwang et al., “Inhibition of lipopolysaccharide (LPS)-induced inflammatory responses by sargassum hemiphyllum sulfated polysaccharide extract in RAW 264.7 Macrophage Cells,” J. Agric. Food Chem., vol. 59, no. 5, pp. 2062–2068, 2011.

A. I. Cholidah, D. Danu, and I. H. Nurrosyidah, “Pengaruh Lama Waktu Fermentasi Kombucha Rosela (Hibiscus sabdariffa L.) Terhadap Aktivitas Antibakteri Escherichia coli,” J. Ris. Kefarmasian Indones., vol. 2, no. 3, pp. 186–210, 2020.

S. E. Byeon et al., “Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng,” Mediators Inflamm., vol. 2012, pp. 7–9, 2012.

J. Y. Seo, C. W. Lee, D. J. Choi, J. Lee, J. Y. Lee, and Y. Il Park, “Ginseng marc-derived low-molecular weight oligosaccharide inhibits the growth of skin melanoma cells via activation of RAW264.7 cells,” Int. Immunopharmacol., vol. 29, no. 2, pp. 344–353, 2015.

C. Y. Shen, J. G. Jiang, L. Yang, D. W. Wang, and W. Zhu, “Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery,” Br. J. Pharmacol., vol. 174, no. 11, pp. 1395–1425, 2017.

W. Wei et al., “TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells,” J. Ethnopharmacol., vol. 179, pp. 243–252, 2016.

Idris, N. Ibrahim, and A. W. Nugrahaani, “Studi Tanaman Berkhasiat Obat Suku Mori Kecamatan Petasia, Petasia Barat, Dan Petasia Timur Kabupaten Morowali Utara Sulawesi Tengah,” Biocelebes, vol. 12, no. 1, pp. 23–31, 2018.

H. Y. Chai, S. M. Lam, and J. C. Sin, “Green synthesis of magnetic Fe-doped ZnO nanoparticles via Hibiscus rosa-sinensis leaf extracts for boosted photocatalytic, antibacterial and antifungal activities,” Mater. Lett., vol. 242, pp. 103–106, 2019.

A. Das, M. C. Das, N. Das, and S. Bhattacharjee, “Evaluation of the antileishmanial potency, toxicity and phytochemical constituents of methanol bark extract of Sterculia villosa,”

Downloads

Published

2022-10-31

Issue

Vol. 4 No. 5 (2022): J. Sains Kes.

Section

Review

Deprecated: json_decode(): Passing null to parameter #1 ($json) of type string is deprecated in /home/jskff/public_html/plugins/generic/citations/CitationsPlugin.php on line 68

How to Cite

[1]
S. R. Khoerunisa, A. Qowiyyah, and S. F. P. Hasyul, “Review: Aktivitas Imunostimulan dari Famili Malvaceae: Review: Immunostimulant Activity from Malvaceae Family”, J. Sains. Kes, vol. 4, no. 5, pp. 523–533, Oct. 2022, Accessed: Feb. 19, 2026. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/550

Most read articles by the same author(s)

Similar Articles

201-210 of 231

You may also start an advanced similarity search for this article.