Profil Aktivitas Enzim Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), dan Alanine Transaminase (ALT) Pada Tikus Hiperlipidemia yang Diberi Madu Fermentasi Bawang Tunggal

Devyana Dyah Wulandari; Suprapto Ma'at; Lysa Veterini; Devi Fitriana Sari; Devyani Diah Wulansari

doi:10.30872/jsk.v6i1.636

Authors

Devyana Dyah Wulandari Universitas Nahlatul Ulama Surabaya Author
Suprapto Ma'at Department of Medical Laboratory Technology, Faculty of Health Author
Lysa Veterini Department of Medicine, Faculty of Medicine Author
Devi Fitriana Sari Department of Medical Laboratory Technology, Faculty of Health Author
Devyani Diah Wulansari Department of Medicine, Faculty of Medicine Author

DOI:

https://doi.org/10.30872/jsk.v6i1.636

Keywords:

Hiperlipidemia, Madu fermentasi, ALP, AST, ALT, Diet tinggi lemak

Abstract

Madu terfermentasi dengan bawang putih telah diketahui memiliki kandungan senyawa fenolat yang tinggi. Penelitian ini bertujuan untuk mengetahui efek suplementasi madu fermentasi terhadap profil aktivitas enzim Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), dan Alanine Transaminase (ALT) pada Tikus Hiperlipidemia. Penelitian ini menggunakan 24 ekor tikus jantan dengan berat badan 200-250 dibagi menjadi 6 kelompok yaitu kontrol negatif, kontrol positif, P1 yang diberi madu fermentasi dosis 0,2 mg/kg BB/hari, kelompok P2 yang diberi madu fermentasi dosis 0,5 mg/kg BB/hari, kelompok P3 yang diberi madu fermentasi dosis 1 mg/kg BB/hari dan kelompok P4 yang diberi simvastatin dosis 1.008 g/l. Kadar ALP, AST, dan ALT serum diukur dengan fotometer. Hasil penelitian menunjukkan nilai signifikansi ALP p=0,152, AST p=0,839, dan ALT p=0,025 dengan p<0,05. Dapat disimpulkan bahwa kadar ALP dan AST yang diberikan madu fermentasi tidak memberikan pengaruh yang signifikan, sedangkan kadar ALT yang diberikan madu fermentasi memberikan pengaruh yang signifikan.

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