Pola Penggunaan I131 Pada Pasien Kanker Tiroid Di Instalasi Kedokteran Nuklir RSUD Abdoel Wahab Sjahranie Samarinda: Usage Patterns Of I131 On Thyroid Cancer At Nuclear Medicine Installation Of RSUD Abdoel Wahab Sjahranie Samarinda

Khairul Zhafirin Bayu Al - Hazmi; Risna Agustina

doi:10.30872/

Authors

Khairul Zhafirin Bayu Al - Hazmi Universitas Mulawarman Author
Risna Agustina Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/

Keywords:

Radionuklir, Radiofarmasi, I131, Kanker Tiroid

Abstract

Kanker tiroid merupakan jenis kanker yang berasal dari mutasi sel tiroid. I¹³¹ merupakan radionuklir yang digunakan untuk teranostik kelenjar tiroid yang menjadi perhatian untuk terapi baru. Penelitian ini bertujuan untuk mengetahui pola penggunaan dari I¹³¹ pada pasien kanker tiroid. Penelitian ini bersifat non – eksperimental menggunakan data rekam medis secara retrospektif yang akan dilakukan analisa secara deskriptif. Hasil yang didapatkan dari penelitian yaitu, pola penggunaan radionuklir yang paling dominan adalah prosedur tiroidektomi, pemeriksaan TSH, dosis 100 mCi, satu hari perawatan, dan kontrol tahunan. Penatalaksanaan lainnya adalah diberikan terapi adjuvan yang disesuaikan dengan efek samping.

References

[1] Shah, J. P. 2015. Thyroid Carcinoma : Epidemiology, Histology, And Diagnosis, Clin Adv Hematol Oncol, 13(4), pp.3-6.

[2] Siriwa, M. R. 2021. Karakteristik Sosiodemografi Dan Klinis Penderita Kanker Tiroid Di RSUP DR Wahidin Sudirohusodo Dan RSP Universitas Hasanuddin Tahun 2018-2021. Makassar : Universitas Hasanuddin.

[3] Zhu, C., dkk. 2023. Near-Death Cells Cause Chemotherapy-Induced Metastasis Via ATF4-Mediated NF-kB Signaling Activation, Adv. Sci, 10(2205835), pp.1-12.

[4] Veiga, L. H. S., dkk. 2012. Chemotherapy And Thyroid Cancer Risk : A Report From The Childhood Cancer Survivor Study, Cancer Epidemiol Biomarkers Prev., 21(1), pp.92-101.

[5] Kailash, & Likar, Y. N. 2016. Advantages And Disadvantages Of Nuclear Medicine Techniques Used In The Diagnosis Of Patients With Neuroblastoma : A Review, Children`s Hematology And Oncology, 3(2), pp.50-56.

[6] Pothisoonthorn, P. 2021. The Capability Of Tc99m MIBI Total Body Scan Compared With I131 Total Body Scan For Detecting Recurrence And Metastasis In Differentiated Thyroid Carcinoma, J DMS, 46(2), pp.39-47.

[7] Heide, C. D. V. D., & Dalm, S. U. 2022. Radionuclide Imaging And Therapy Directed Towards The Tumor Microenvironment : A Multi-Cancer Approach For Personalized Medicine, European Journal Of Nuclear Medicine And Molecular Imaging, 49, pp.4616–4641.

[8] Tran, K. B., dkk. 2022. The Global Burden Of Cancer Attributable To Risk Factors, 2010-19 : A Systematic Analysis For The Global Burden Of Disease Study 2019, Lancet, 400, pp.563-591.

[9] Derwahl, M., & Nicula, D. 2014. Estrogen And Its Role In Thyroid Cancer, Society For Endocrinology, 21(5), pp.273-283. http://dx.doi.org/10.1530/ERC-14-0053

[10] Chen, L. H., Xie, T., Lei, Q. Gu, Y. R., & Sun, C. Z. 2024. A Review Of Complex Hormone Regulation In Thyroid Cancer: Novel Insights Beyond The Hypothalamus-Pituitary-Thyroid Axis, Frontiers In Endocrinology, 15(1419913), pp.1-15. https://doi.org/10.3389/fendo.2024.1419913

[11] Palmer, A. K., & Jensen, M. D. 2022. Metabolic Changes In Aging Humans: Current Evidence And Therapeutic Strategies, The Journal Of Clinical Investigation, 132(16), pp.1-8. https://doi.org/10.1172/JCI158451

[12] Li, P., dkk. 2012. Occupational And Environmental Cancer Incidence And Mortality In China, Occupational Medicine, 62(4), pp.281-287. doi:10.1093/occmed/kqs016

[13] Collatuzzo, G., Teglia, F., & Boffetta, P. 2022. Role Of Occupation In Shaping Cancer Disparities, MDPI Cancer, 14(4259), pp.1-15. https://doi.org/10.3390/cancers14174259

[14] Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S, 2021. Stress And Cancer: Mechanisms, Significance And Future Directions, Nature Reviews : Cancer, 21(12), pp.767-785. http://dx.doi.org/10.1038/s41568-021-00395-5

[15] Petrinovic, S. V., Milosevic, M. S., Markovic, D., & Momcilovic, S. 2023. Interplay Between Stress And Cancer-A Focus On Inflammation, Frontiers In Physiology, 14(1119095), pp.1-8. https://doi.org/10.3389/fphys.2023.1119095

[16] Takeshima, H., & Ushijima, T. 2019. Accumulation Of Genetic And Epigenetic Alterations In Normal Cells And Cancer Risk, Precision Oncology, 3(7), pp.1-8. https://doi.org/10.1038/s41698-019-0079-0

[17] Parsa, N. 2012. Environmental Factors Inducing Human Cancers, Iranian J Publ Health, 41(11), pp. 1-9. http://ijph.tums.ac.ir/

[18] Zhang, J., & Xu, S. 2024. High Aggressiveness Of Papillary Thyroid Cancer: From Clinical Evidence To Regulatory Cellular Networks, Cell Death Discovery. 10(378), pp.1-15. https://doi.org/10.1038/s41420-024-02157-2

[19] Wu, M. H., Lee, Y. Y., Lu, Y. L., & Lin, S. F. 2022. Risk Factors And Prognosis For Metastatic Follicular Thyroid Cancer, Frontiers In Endocrinology, 13(791826), pp.1-9. https://doi.org/10.3389/fendo.2022.791826

[20] Parameswaran, B., Hu, J. S., En, N. M., Tan, W. B., & Yuan, N. K. 2017. Patterns Of Metastasis In Follicular Thyroid Carcinoma And The Difference Between Early And Delayed Presentation, Ann R Coll Surg Engl, 99(2), pp.151-154. https://doi.org/10.1308/rcsann.2016.0300

[21] Zhang, S., dkk. 2024. Tumor Initiation And Early Tumorigenesis: Molecular Mechanisms And Interventional Targets, Signal Transduction and Targeted Therapy, 9(149), pp.1-36. https://doi.org/10.1038/s41392-024-01848-7

[22] Xing, P., dkk. 2023. Treatment Strategies And Drug Resistance Mechanisms In Adenocarcinoma Of Different Organs, Drug Resistance Update, 71(101002), pp.1-11. https://doi.org/10.1016/j.drup.2023.101002

[23] Coca-Pelaz, A., dkk. 2021. Hurthle Cell Carcinoma Of The Thyroid Gland: Systematic Review And Meta-Analysis, Adv Ther, 38, pp.5144-5164. https://doi.org/10.1007/s12325-021-01876-7

[24] Chindris, A. M., dkk. 2015. Clinical And Molecular Features Of Hürthle Cell Carcinoma Of The Thyroid, J Clin Endocrinol Metab, 100(1), pp.55-62. https://doi.org/10.1210/jc.2014-1634

[25] Angeousi, A., Hayes, A. R., Chatzellis, E., Kaltsas, G. A., & Grossman, A. B. 2022. Metastatic Medullary Thyroid Carcinoma: A New Way Forward, Endocrine Related Cancer, 29(7), pp.85-103. https://doi.org/10.1530/ERC-21-0368

[26] Kazakou, P., Simeakis, G., Alevizaki, M., & Saltiki, K. 2021. Medullary Thyroid Carcinoma (MTC): Unusual Metastatic Sites, Endocrinology Diabetes & Metabolism, 21(63), pp.1-5. https://doi.org/10.1530/EDM-21-0063

[27] Lee, J. S., dkk. 2022. Prognosis Of Anaplastic Thyroid Cancer With Distant Metastasis, MDPI Cancers, 14(5784), pp.1-10. https://doi.org/10.3390/cancers14235784

[28] Stenman, A., dkk., 2020. Metastatic Anaplastic Thyroid Carcinoma In Complete Remission: Morphological, Molecular, And Clinical Work-Up Of A Rare Case, Endocrine Pathology, 31, pp.77-83. https://doi.org/10.1007/s12022-020-09606-5

[29] Rianto, B. U. D., Wibowo, A. S., & Herdini, C. 2019. The Role Of Thyroid Stimulating Hormone Level As A Predictive Factor For Advance Stage Thyroid Carcinoma, Journal Of The Medical Sciences, 51(4), pp.340-350. http://dx.doi.org/10.19106/JMedSci005104201908

[30] Alaraifi, A. K., Alessa, M., Hijazi, L. O., Alayed, A. M., & Alsalem, A. A. 2023. TSH Level As A Risk Factor Of Thyroid Malignancy For Nodules In Euthyroid Patients, Acta Otorhinolaryngologica Italica, 43(3), pp.183-188. https://doi.org/10.14639/0392-100X N2288

[31] Fan, X. Y., dkk. 2024. A Meta-Analysis Of The Value Of Serum Tsh Concentration In The Diagnosis Of Differentiated Thyroid Cancer In Patients With Thyroid Nodules, Heliyon, 10(2), pp.1-11. https://doi.org/10.1016/j.heliyon.2024.e24391

[32] Zhang, S., dkk. 2024. Tumor Initiation And Early Tumorigenesis: Molecular Mechanisms And Interventional Targets, Signal Transduction and Targeted Therapy, 9(149), pp.1-36. https://doi.org/10.1038/s41392-024- 01848-7

[33] Signore, A., dkk. 2023. Predictive Role Of Serum Thyroglobulin After Surgery And Before Radioactive Iodine Therapy In Patients With Thyroid Carcinoma, MDPI Cancers, 15(2976), pp.1-13. https://doi.org/10.3390/cancers15112976

[34] Holsinger, F. C., dkk. 2022. Measuring The Extent Of Total Thyroidectomy For Differentiated Thyroid Carcinoma Using Radioactive Iodine Imaging Relationship With Serum Thyroglobulin And Clinical Outcomes, JAMA Otolaryngol Head Neck Surg, 140(5), pp.410-415. https://doi.org/10.1001/jamaoto.2014.264

[35] Li, S., dkk. 2022. The Role Of Thyroglobulin In Preoperative And Postoperative Evaluation Of Patients With Differentiated Thyroid Cancer, Frontiers In Endocrinology, 13(872527), pp.1-12. https://doi.org/10.3389/fendo.2022.872527

[36] Zhang, X., Tianl., Teng, D., & Teng, W. 2023. The Relationship Between Thyrotropin Serum Concentrations And Thyroid Carcinoma, MDPI Cancers, 15(5017), pp.1-14. https://doi.org/10.3390/cancers15205017

[37] Dewi, I G, A. S., & Seputra, D. P. G. S. 2020. Differences In Pre-Operative Mean Serum Concentration Of Thyroid Stimulating Hormone (TSH) And Free Thyroxin (FT4) In Patients With Benign Thyroid Nodules And Thyroid Carcinoma At Sanglah General Hospital Denpasar, Indonesian Journal Of Cancer, 16(1), pp.3-8. http://dx.doi.org/10.33371/ijoc.v16i1.813

[38] Yang, Y., Jiao, Y., Yu, J., & Wang, C. 2019. Clinical Treatment Efficacy Of Total Thyroidectomy Combined With Radioactive Iodine On Treatment Of Thyroid Cancer And Its Effect On The Quality Of Life Of Patients, Iran J Public Health, 48(8), pp.1461-1468. http://ijph.tums.ac.ir/

[39] Toraih, E. A., dkk. 2024. Initial Versus Staged Thyroidectomy For Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis Of Effectiveness And Safety, MDPI Cancers, 16(2250), pp.1-17. https://doi.org/10.3390/cancers16122250

[40] Li, G., & Wu, L. 2022. Total Or Near-Total Thyroidectomy In Treatment Of Thyroid Cancer, Pakistan Journal Of Medical Sciences, 38(6), pp.1661 1667. https://doi.org/10.12669/pjms.38.6.5765

[41] Choi, J. B., dkk. 2018. Oncologic Outcomes In Patients With 1-Cm To 4-Cm Differentiated Thyroid Carcinoma According To Extent Of Thyroidectomy, Journal Of The Sciences And Specialities Of The Head And Neck, 41(1), pp.56-63. https://doi.org/10.1002/hed.25356

[42] Cherenko, S. M., Glagolieva, A. Y., & Makhmudov, D. E. 2024. Radioiodine Ablation After Thyroidectomy Could Be Safely Abandoned Or Postponed In Selected Stage I Papillary Thyroid Carcinoma Patients Of Low-Risk Group: An Observational Prospective Study, International Journal Of Endocrinology, 20(1), pp.7-10. https://doi.org/10.22141/2224-0721.20.1.2024.1351

[43] Demoor-Goldschmidt, C., & De Vathaire, F. 2019. Review Of Risk Factors Of Secondary Cancers Among Cancer Survivors, British Journal Of Radiology, 92(1093), pp.1-8. https://doi.org/10.1259/bjr.20180390

[44] Karagiannis, G. S., Condeelis, J. S., & Oktay, M. H. 2018. Chemotherapy-Induced Metastasis: Mechanisms And Translational Opportunities, Clin Exp Metastasis, 35(4), pp.269-284. https://doi.org/10.1007/s10585-0179870-x

[45] Klain, M., dkk. 2021. Whole-Body Radioiodine Effective Half-Life In Patients With Differentiated Thyroid Cancer, MDPI Diagnostics, 11(1740), pp.1-9. https://doi.org/10.3390/diagnostics11101740

[46] Alamgeer, M.. dkk. 2023. Frailty And Long-Term Survival Among Patients In Australian Intensive Care Units With Metastatic Cancer (FRAIL-CANCER Study): A Retrospective Registry-Based Cohort Study, Lancet Healthy Longev, 4(12), pp.675-684. https://doi.org/10.1016/s2666-7568(23)00209-x

[47] Ameri, M., Ali, N., Dickson, K., Koom-Dabzle, K., & Al-Ameri, A. 2022. Analysis Of Extended Length Of Stay In A Comprehensive Cancer Center, Recent Adv Clin Trials, 1(1), pp.1-6. http://dx.doi.org/10.33425/2771- 9057.1006

[48] Sharma, A., dkk, 2017. Estimation Of Effective Half-Life Of I131 In Differentiated Thyroid Cancer Patients In A Tertiary Care Hospital In India: A Retrospective Study, JMSCR, 5(3), pp.18740-18746. https://dx.doi.org/10.18535/jmscr/v5i3.76

[49] Lawhn-Heath, C., Dkk. 2022. Dosimetry In Radionuclide Therapy: The Clinical Role Of Measuring Radiation Dose, The Lancet Oncology, 23(2), pp.75-87. https://doi.org/10.1016/S1470-2045(21)00657-4

[50] Barakat, A., Santoro, L., Vivien, M., Kotzki, P. O., Deshayes, E., & Khier, S. 2023. Clinical Pharmacokinetics Of Radiopharmaceuticals From SPECT/CT Image Acquisition By Contouring In Patients With Gastroenteropancreatic Neuroendocrine Tumors: Lu177 DOTATATE (Lutathera®) Case, European Journal Of Drug Metabolism And Pharmacokinetics, 48(4), pp.329-339. https://doi.org/10.1007/s13318-023-00829-5

[51] Solanki, J. H., dkk. 2017. Cellular Response To Exponentially Increasing And Decreasing Dose Rates: Implications For Treatment Planning In Targeted Radionuclide Therapy, Radiation Research, 188(2), pp.221-234. https://pmc.ncbi.nlm.nih.gov/articles/PMC5669265/

[52] Szumowski, P., dkk. 2021. Dosimetry During Adjuvant I131 Therapy In Patients With Differentiated Thyroid Cancer-Clinical Implications, Scientific Reports, 11(13930), pp.1-8. https://doi.org/10.1038/s41598-021-93431-1

[53] Karimzadeh, A., dkk. 2024. Organ And Tumor Dosimetry Including Method Simplification For [177Lu]Lu-PSMA-I&T For Treatment Of Metastatic Castration Resistant Prostate Cancer, EJNMMI Physics, 11(63), pp.1-20. https://doi.org/10.1186/s40658-024-00668-6

[54] Mandal, B., dkk. 2023. A Prospective Study Comparing Dosimetry Between Computed Tomography (CT) Based Radiation Planning And Positron Emission Computed Tomography (PET-CT) Based Radiation Planning In Treatment Of Non-Metastatic Non-Small Cell Lung Carcinoma, Asian Pacific Journal Of Cancer Prevention, 24(7), pp.2543-2550. https://doi.org/10.31557/apjcp.2023.24.7.2543

[55] Kayal, G., dkk. 2024. Quality Assurance Considerations In Radiopharmaceutical Therapy Dosimetry Using PLANETDose: An International Atomic Energy Agency Study, J Nucl Med, 65(1), pp.125-131. https://doi.org/10.2967/jnumed.122.265340

[56] O`Donoghue, J., Zanzonico, P., Humm, J., & Kesner, A. 2022. Dosimetry In Radiopharmaceutical Therapy, J Nucl Med, 63(10), pp.1467-1474. https://doi.org/10.2967/jnumed.121.262305

[57] Lassmann, M., & Eberlein, U. 2018. The Relevance Of Dosimetry In Precision Medicine, J Nucl Med, 59 (10) 1494-1499. https://doi.org/10.2967/jnumed.117.206649

[58] Miura, K., dkk. 2021. Impact Of Concomitant Medication On Clinical Outcomes In Patients With Advanced Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors: A Retrospective Study, Thorac Cancer, 12(13), pp.1983-1994. https://doi.org/10.1111/1759-7714.14001

[59] Ahn, B. C., 2016. Personalized Medicine Based On Theranostic Radioiodine Molecular Imaging For Differentiated Thyroid Cancer, BioMed Research International 2016(1), pp.1-9. http://dx.doi.org/10.1155/2016/1680464

[60] Piwowarska-Bilska, H., Kurkowska, S., & Birkenfeld, B. 2022. Individualization Of Radionuclide Therapies: Challenges And Prospects, Cancers, 14(3418), pp.1-16. https://doi.org/10.3390/cancers14143418

[61] Kwak, D., Ha, J., Won, Y., Kwon, Y., & Park, S. 2020. Effects Of Thyroid-Stimulating Hormone Suppression After Thyroidectomy For Thyroid Cancer On Bone Mineral Density In Postmenopausal Women: A Systematic Review And Meta – Analysis, BMJ Open, 11(5), pp.1-11. https://doi.org/10.1136/bmjopen-2020-043007

[62] Jin, J., Allemang, M. T., & McHenry, C. R., 2013. Levothyroxine Replacement Dosage Determination After Thyroidectomy, The American Journal Of Surgery, 205(3), pp.360-364. http://dx.doi.org/10.1016/j.amjsurg.2012.10.015

[63] Siino, G. P. R., dkk. 2016. Efficacy, Safety And Effectiveness Of Ondansetron Compared To Other Serotonin – 3 Receptor Antagonists (5 – HT3RAs) Used To Control Chemotherapy – Induced Nausea And Vomiting: Systematic Review And Meta – Analysis, Expert Review Of Clinical Pharmacology, 9(6), pp.1-43. http://dx.doi.org/10.1080/17512433.2016.1190271

[64] Tricco, A. C., dkk. 2015. Comparative Efficacy Of Serotonin (5 – HT3) Receptor Antagonists In Patients Undergoing Surgery: A Systematic Review And Network Meta – Analysis, BMC Medicine, 13(316), pp.1-13. https://doi.org/10.1186/s12916-015-0371-y

[65] Salvo, N., dkk. 2012. Prophylaxis Of Radiation – Induced Nausea And Vomiting Using 5 – Hydroxytryptamine – 3 Serotonin Receptor Antagonists: A Systematic Review Of Randomized Trials, Int. J. Radiation Oncology Biol. Phys., 82(1), pp.408-417. http://dx.doi.org/10.1016/j.ijrobp.2010.08.060

[66] Yokoi, A., Mihara, T., Ka, K., & Goto, T. 2017. Comparative Efficacy Of Ramosetron And Ondansetron In Preventing Postoperative Nausea And Vomiting: An Updated Systematic Review And Meta-Analysis With Trial Sequential Analysis, PloS ONE, 12(10), pp.1-25. https://doi.org/10.1371/journal.pone.0186006

[67] Ashour, A. M. 2023. The Preventive Effects Of Ondansetron On Chemotherapy-Induced Nausea And Vomiting In Adult Cancer Patients: Systematic Review From Clinicaltrials.gov, Frontiers In Pharmacology, 14(1310455), pp.1-6. https://doi.org/10.3389/fphar.2023.1310455

[68] Chen, G., Yu, Z., Zhang, Y., Liu, S., Chen, C., & Zhang, S. 2023. Radiation-Induced Gastric Injury During Radiotherapy: Molecular Mechanisms And Clinical Treatment, Journal Of Radiation Research, 64(6), pp.870-879. https://doi.org/10.1093/jrr/rrad071

[69] Holik, A. K., dkk. 2021. Gastric Serotonin Biosynthesis And Its Functional Role In L – Arginine – Induced Gastric Proton Secretion, MDPI International Journal Of Molecular Sciences, 22(5881), pp.1-15. https://doi.org/10.3390/ijms22115881

[70] Guzel, T., & Mirowska – Guzel, D. 2022. The Role Of Serotonin Neurotransmission In Gastrointestinal Tract And Pharmacotherapy, MDPI Molecules, 27(1680), pp.1-16. https://doi.org/10.3390/molecules27051680

[71] Begg, M., dkk. 2023. Comparing The Safety And Efficacy Of Proton Pump Inhibitors And Histamine – 2 Receptor Antagonists In The Management Of Patients With Peptic Ulcer Disease: A Systematic Review, Cureus, 15(8), pp.1-10. https://doi.org/10.7759/cureus.44341

[72] Prasad, M., McFarland, L. V., Thacker, H. P., Puri, R., & Lawate, P. S. 2024. Efficacy And Safety Of Omeprazole For The Treatment Of Acid Peptic Disorders: A Systematic Review And Meta – Analysis, International Journal Of Clinical Practice, 1(9990554), pp.1-13. https://doi.org/10.1155/2024/9990554

[73] Belkacemi, L., & Darmani, N. A. 2020. Dopamine Receptors In Emesis: Molecular Mechanisms And Potential Therapeutic Function, Pharmacol Res, 161(105124), pp.1-60. https://doi.org/10.1016/j.phrs.2020.105124

[74] Junqueira, D. R., Bennett, D., Huh, S. Y., Fahrbach, K., Neupane, B., & Betts, M. 2023. Risk Of Adverse Events Associated With Domperidone And Metoclopramide In Gastroparesis: Systematic Review And Meta – Analysis, Drugs In R&D, 23, pp.1-20. https://doi.org/10.1007/s40268-023-00413-x

[75] Alkhowaiter, S., dkk. 2024. Safety Of Prolonged Use Of Metoclopramide And Domperidone As Treatment For Chronic Gastrointestinal Dysmotility Disorders In Patients With Systemic Sclerosis, Saudi Pharmaceutical Journal, 32(102039), pp.1-5. https://doi.org/10.1016/j.jsps.2024.102039

[76] Dyhrfjeld – Johnsen, J., & Attali, P. 2019. Management Of Peripheral Vertigo With Antihistamines: New Options On The Horizon, Br J Clin Pharmacol, 85(10), pp.2255-2263. https://doi.org/10.1111/bcp.14046

[77] Parfenov, V. A., dkk. 2017. Effectiveness Of Betahistine (48 Mg/Day) In Patients With Vestibular Vertigo During Routine Practice: The VIRTUOSO Study, PLoS ONE, 12(3), pp.1-11. https://doi.org/10.1371/journal.pone.0174114

[78] Gameiro, B. S., dkk. 2024. Betahistine In The Treatment Of Peripheral Vertigo: An Evidence – Based Review, The Egyptian Journal Of Otolaryngology, 40(108), pp.1-12. https://doi.org/10.1186/s43163-024-00674-6

[79] Mallet, C., Dusmeules, J., Pegahi, R., & Eschalier, A. 2023. An Updated Review On The Metabolite (AM404) – Mediated Central Mechanism Of Action Of Paracetamol (Acetaminophen): Experimental Evidence And Potential Clinical Impact, Journal Of Pain Research, 16, pp.1081-1094. https://doi.org/10.2147/jpr.s393809

[80] Shaheed, C. A., dkk. 2021. The Efficacy And Safety Of Paracetamol For Pain Relief: An Overview Of Systematic Reviews, Med J Aust, 214(7), pp.324-331. https://doi.org/10.5694/mja2.50992

[81] Ghanem, M. A. 2021. Efficacy Of Interrupted Cyclic Treatment With Prednisolone On Cancer Pain: A Randomized Crossover Study, Journal Of Anesthesiology, 13(52), pp.1-9. https://doi.org/10.1186/s42077-021-00169-z

[82] Leppert, W., & Buss, T. 2012. The Role Of Corticosteroids In The Treatment Of Pain In Cancer Patients, Curr Pain Headache Rep, 16(4), pp.307-313. https://doi.org/10.1007/s11916-012-0273-z

[83] Tay, E. M. Y., & Roberts, D. M. 2018. A Spotlight On The Role, Use, And Availability Of Codeine And The Implications Faced, Expert Review Of Clinical Pharmacology, 11(11), pp.1057-1059. https://doi.org/10.1080/17512433.2018.1537122

[84] Celic, I., Bach – Rojecky, L., Mercep, I., Soldo, A., Petrak, A. K., & Bucan, A. 2020. Resolving Issues About Efficacy And Safety Of Lowdose Codeine In Combination Analgesic Drugs: A Systematic Review, Pain Ther, 9, pp.171-194. https://doi.org/10.1007/s40122-020-00162-8

[85] Deslandes, M., dkk. 2024. Effectiveness And Safety Of Prehospital Analgesia With Nalbuphine And Paracetamol Versus Morphine By Paramedics – An Observational Study, Scandinavian Journal Of Trauma, Resuscitation, & Emergency Medicine, 32(42), pp.1-8. https://doi.org/10.1186/s13049-024-01215-z

[86] Milella, M. S., D`Ottavio, G., Pirro, S. D., Barra, M., Capriolli, D., & Badiani, A. 2023. Heroin And Its Metabolites: Relevance To Heroin Use Disorder, Translational Psychiatry, 13(120), pp.1-16. https://doi.org/10.1038/s41398-023-02406-5

[87] Okada, M., & Nose, T. 2024. Eperisone Hydrochloride, A Muscle Relaxant, Is A Potent P2X7 Receptor Antagonist, Chem Pharm Bull, 72(3), pp.345-348. https://doi.org/10.1248/cpb.c24-00032

[88] Oldfield, B. J., dkk. 2024. Long – Term Use Of Muscle Relaxant Medications For Chronic Pain A Systematic Review, JAMA Network Open, 7(9), pp.1-12. https://doi.org/10.1001/jamanetworkopen.2024.34835

[89] Einhorn, O. M., Georgiou, K., & Tompa, A. 2020. Salivary Dysfunction Caused By Medication Usage, Physiology International, 107(2), pp.195-208. http://dx.doi.org/10.1556/2060.2020.00019

[90] Corsico, A. G., dkk. 2019. Focus On The Cetirizine Use In Clinical Practice: A Reappraisal 30 Years Later, Multidisciplinary Respiratory Medicine, 14(40), pp.1-7. https://doi.org/10.1186/s40248-019-0203-6

[91] Rizvi, S. A. A., Ferre, G., Khawaja, U. A., & Sanchez – Gonzales, M. A. 2022. Chlorpheniramine, An Old Drug With New Potential Clinical Applications: A Comprehensive Review Of The Literature, Current Reviews IN Clinical AND Experimental Pharmacology,19(2), pp137-145. https://doi.org/10.2174/2772432817666220601162006

[92] Abdelrahman, T. N., & Kasem, A. A. 2020. Role Of Preemptive Chlorpheniramine Maleate In Reducing Postoperative Agitation After Functional Endoscopic Sinus Surgeries (FESS), Journal Of Anesthesiology, 12(26), pp.1-8. https://doi.org/10.1186/s42077-020-00074-x

[93] Ohar, J. A., Donohue, J. F., & Spangenthal, S. 2019. The Role Of Guaifenesin In The Management Of Chronic Mucus Hypersecretion Associated With Stable Chronic Bronchitis: A Comprehensive Review, JCOPDF, 6(4), pp.341-349. https://doi.org/10.15326/jcopdf.6.4.2019.0139

[94] Albrecht, H. H., Dicpinigaitis, P. V., & Guenin, E. P. 2017. Role Of Guaifenesin In The Management Of Chronic Bronchitis And Upper Respiratory Tract Infections, Multidisciplinary Respiratory Medicine, 12(31), pp.1-11. https://doi.org/10.1186/s40248-017-0113-4

[95] Glowacka, K., & Wiela – Hojenska, A. 2021. Pseudoephedrine – Benefits And Risks, MDPI International Journal Of Molecular Sciences, 22(5146), pp,.1-11. https://doi.org/10.3390/ijms22105146

[96] Febbraro, S., Shea, T., & Cravo, A. S. 2020. Bioavailability Of Triprolidine As A Single Agent Or In Combination With Pseudoephedrine: A Randomized, Open – Label Crossover Study In Healthy Volunteers, Clinical Pharmacology In Drug Development, 9(4), pp.486-495. https://doi.org/10.1002/cpdd.777

[97] Taylor, C. P., Traynelis, S. F., Siffert, J., Pope, L. E., & Matsumoto, R. R. 2016. Pharmacology Of Dextromethorphan: Relevance To Dextromethorphan/ Quinidine (Nuedexta®) Clinical Use, Pharmacology & Therapeutics, 164, pp.170-182. http://dx.doi.org/10.1016/j.pharmthera.2016.04.010

[98] Ghosh, A. 2019. Comparison Of Safety And Efficacy Of Dextromethorphan And Levocloperastine In Treatment Of Dry Cough: A Randomized Open Label Phase IV Clinical Trial, International Journal Of Basic & Clinical Pharmacology, 8(10), pp.2284-2287. http://dx.doi.org/10.18203/2319-2003.ijbcp20194272

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