Formulasi Nanonanoemulgel Tea Tree Melaleuca alternifolia Oil dengan Menggunakan Full Factorial Design

Formulation Nanonanoemulgel Tea Tree Melaleuca alternifolia Oil using Full Factorial Design

Authors

  • Asti Rahayu Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Dewi Perwito Sari Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Ira Purbosari Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Prisma Trida Hardani Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Faqihuddin Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Wahyudi Program Studi Farmasi, Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya Author
  • Astrid Kusuma Putri Program Studi Farmasi, Fakultas Kedokteran Universitas Hang Tuah Author

Keywords:

Nanoemulgel, Tea tree oil, Carbopol 940, Tween 80, Design

Abstract

Tea tree oil (TTO) merupakan minyak esensial yang berasal dari Melaleuca alternifolia mengandung terpinen-4-ol. TTO memiliki aktivitas sebagai antimikroba. TTO gel bersifat hidrofobik sehingga membutuhkan sistem penghantaran untuk bisa berpenetrasi melewati stratum korneum. Tujuan dari penelitian ini adalah untuk membuat nanoemulgel TTO, menggunakan Carbopol 940 dan  Tween 80 digunakan sebagai surfaktan. Optimasi dan formulasi pada rancangan full factorial design adalah konsentrasi gelling agent Carbopol 940 (X1) dan konsentrasi  emulgator tween 80 (X2). Optimasi formula ini bertujuan untuk mendapatkan hasil optimal pada variabel tergantung (Y) yaitu ukuran partikel (Y1), daya sebar (Y2), dan zeta potensial (Y3). Ukuran partikel dari nanoemulgel TTO memiliki rentang 363,5± 0.13 sampai 813,5 ± 0,5 nm, daya sebar memiliki rentang 5,8 ± 0,4 sampai 7,2 ± 0,2 cm, dan zeta potensial memiliki rentang nilai 20,9 ± 0,8 sampai 57,5 ± 0,6 mV. Variabel bebas memiliki nilai signifikan terhadap ukuran partikel dengan nilai p < 0,05, namun memiliki efek tidak signifikan terhadap daya sebar dan Zeta potensial, dengan nilai p > 0,05

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Published

2024-11-14

Issue

Vol. 4 No. 6 (2022): J. Sains Kes.

Section

Articles

How to Cite

[1]
A. Rahayu, “Formulasi Nanonanoemulgel Tea Tree Melaleuca alternifolia Oil dengan Menggunakan Full Factorial Design: Formulation Nanonanoemulgel Tea Tree Melaleuca alternifolia Oil using Full Factorial Design”, J. Sains. Kes, vol. 4, no. 6, pp. 614–620, Nov. 2024, Accessed: Oct. 13, 2025. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/484

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